DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCC1 and ssr2

DIOPT Version :10

Sequence 1:NP_003065.3 Gene:SMARCC1 / 6599 HGNCID:11104 Length:1105 Species:Homo sapiens
Sequence 2:NP_593800.1 Gene:ssr2 / 2541851 PomBaseID:SPAC23H3.10 Length:503 Species:Schizosaccharomyces pombe


Alignment Length:558 Identity:178/558 - (31%)
Similarity:250/558 - (44%) Gaps:193/558 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   442 VTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYL 506
            :.|||..||:||||.|||.:.||.||||:.|||||||:..|||.||..||:|||::|||.|.|||
pombe    11 LVEQTYPIIVPSYAGWFDMSKIHDIERRSNPEFFNGKSPLKTPSIYKDYRDFMINSYRLEPNEYL 75

Human   507 TSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTP-------- 563
            |.|||||||.|||||::|||||||||||:|||:|||:||....||.:.|...:::||        
pombe    76 TVTACRRNLVGDVCAIIRVHAFLEQWGLINYQIDPETRPAFRLPPISGHVQAISNTPIVTQEMLA 140

Human   564 -------------SGLVPLHLR--SPQVPAAQQMLNFPEKNKEKP-----VD------------- 595
                         ...|.|..:  ||.:.|.:|  ..|::..||.     ||             
pombe   141 QHPPPSTVGGSSSQEFVKLEEKHYSPSLNAMEQ--TSPKEEDEKSDKVPRVDKVCFTCGVNCSQT 203

Human   596 ----LQN--FGLRTDIYSKKTLAKSKGAS-------------AGREWTEQETLLLLEALEMYKDD 641
                |:|  :.:..:.|.:...:.|..:|             ..:.|:.|||||||||:|.|.||
pombe   204 WYHNLKNKKYDICPNCYKQGRFSSSFNSSDFLCMDAIDFNHDEEKPWSNQETLLLLEAIETYGDD 268

Human   642 WNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVV 706
            ||:::.||||||:::|::|||::||||||.:.......|.....:||.::.|||:||:.:|||:|
pombe   269 WNQIALHVGSRTKEQCLIHFLQIPIEDPYRQKLQGDFSPFKKGFLPFDENENPVLSTLTYLASIV 333

Human   707 DPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPE 771
            .                                                                
pombe   334 Q---------------------------------------------------------------- 334

Human   772 KLEGAEEEKMEADPDGQQPEKAENKVENETDEGDKAQDGENEKNSEKEQDSEVSEDTKSEEKETE 836
              :|.:|.|..           |:..:.||..|          |||.:...|             
pombe   335 --QGMKERKQN-----------ESVKQGETSFG----------NSEFKNPLE------------- 363

Human   837 ENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVE 901
                                           ..|..||.|||.|||.:||.|.|:::.||..|::
pombe   364 -------------------------------RVAYYALKSAAQKAKLIAAFENRQLRRLVFSLIQ 397

Human   902 TQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTER 939
            .|::||::|::..|:||.:...|...|:.:.:.||..|
pombe   398 AQLEKLQLKMKVLEQLEKMCSLELSELDLRGKNLLLSR 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCC1NP_003065.3 MarR-like, BRCT and chromo domains module. /evidence=ECO:0000255|PROSITE-ProRule:PRU01376 28..302
SWIRM-assoc_2 32..445 CDD:465143 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 296..439
RSC8 444..>710 CDD:227584 139/325 (43%)
SWIRM-assoc_3 706..772 CDD:465145 1/65 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 745..860 11/114 (10%)
SWIRM-assoc_1 883..954 CDD:465142 19/57 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 956..1028
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1041..1105
ssr2NP_593800.1 RSC8 1..503 CDD:227584 178/558 (32%)
Blue background indicates that the domain is not in the aligned region.

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