Protein Alignment SMARCC1 and swsn-1

DIOPT Version :10

• Sequence 1: NP_003065.3
• Gene: SMARCC1 / 6599
• HGNCID: 11104
• Length: 1105
• Species: Homo sapiens
• Sequence 2: NP_001256907.1
• Gene: swsn-1 / 180324
• WormBaseID: WBGene00004203
• Length: 792
• Species: Caenorhabditis elegans
• Alignment Length: 879
• Identity: 360/879 - (40%)
• Similarity: 459/879 - (52%)
• Gaps: 233/879 - (26%)

Human   345 KKGQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKKDSENTPVKGGTVADLD 409
            |||     ..:|.:.::|....:|.|.:|......: :|.:||  ..:||:|.:..||..:.|||
 Worm     2 KKG-----ASKRRRDDDDGDVSMTGDDDDSRSGAAV-KVEVPK--GKEKDAEFSAPKGQKLTDLD 58

Human   410 EQDEETVTAGGKEDEDPAKGDQS--RSVDLGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALP 472
            |:                 |.||  .:..|.|.||.|||::|::||||.|||||.||.||:||:|
 Worm    59 EE-----------------GVQSTKEAPQLAEGNVIEQTHYIVVPSYAGWFDYNAIHQIEKRAMP 106

Human   473 EFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNY 537
            ||||||||||||::|:||||||:|||||||.||:::|||||||.||||:::|:|:|||||||:||
 Worm   107 EFFNGKNKSKTPDVYVAYRNFMVDTYRLNPFEYVSATACRRNLAGDVCSIVRLHSFLEQWGLLNY 171

Human   538 QVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPVDLQNF--- 599
            |||.::||..:.||||.||.||||||:|:.|::....:...|.   ..|.|.:.| .::::.
 Worm   172 QVDSDARPAPVAPPPTSHFMVLADTPTGIQPMNPPGKESAGAS---GEPPKEEIK-TEIESISTP 232

Human   600 GLRTDIYSKKTLA-KSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLR 663
            ||:.|.|.|:.:| ::|||..||:||||||.||||||||:|||||||.:|||:|||.||:|.||:
 Worm   233 GLKIDQYQKQAIAMRTKGAPPGRDWTEQETCLLLEALEMFKDDWNKVCDHVGTRTQHECVLKFLQ 297

Human   664 LPIEDPYL-EN--SDAS-----------LGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAA 714
            |||:|||| ||  ||.:           |||||:|||||||||||||||||||||||||:||:||
 Worm   298 LPIQDPYLTENLSSDKAEAAPGGAAKEVLGPLAFQPVPFSQSGNPVMSTVAFLASVVDPQVAAAA 362

Human   715 AKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEE 779
            .|||:|||.:::||:|..:.|||.|.|...|..:|:||...||..|     |....|:..|..:|
 Worm   363 TKAAMEEFGKLKEEIPPLVAEAHEKNVAAMAEKTGQVDGAVGLTKS-----GLKPAEEAAGDSDE 422

Human   780 KMEADPDGQQPEKAENKVENETDEGDKAQDGENEKNSEKEQDSEVSEDTKSEEKETEENKELTDT 844
            ||:.:.:...|...|.|  :..|:|
 Worm   423 KMDTNTNDDVPSTTEAK--SAIDKG---------------------------------------- 445

Human   845 CKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEI 909
                                 |..|||:.||:||.||||||.:|||:||||||.||||||||||:
 Worm   446 ---------------------VQAAAASCLAAAAVKAKHLAQIEERRIKSLVAQLVETQMKKLEM 489

Human   910 KLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQ----------------- 957
            |||||:|||.|||:|:|:||.||.||:.|||.|||:||||.|.||:.:
 Worm   490 KLRHFDELEQIMDKERESLEYQRHQLILERQAFHMDQLKYLENRAKHEAHSRMTSSGALPAGLPP 554

Human   958 --------------------------------------------------------MEQQQHGQN 966
                                                                    ::..|..|.
 Worm   555 GFEVTGPPQPTPQVQISAQEAAIPEKMDTSEAATAARPPSTPQAPQAPPVQAAPAPVQAPQAPQA 619

Human   967 PQQAHQHSGGPGLAPLGAAGHP---GMMPHQQPPPYPLMHHQM-------------------PPP 1009
            |.||:|..||||..|..|..:|   |......|||.....||.                   |||
 Worm   620 PPQAYQGYGGPGGPPQQAYRYPPQQGQQYSPYPPPQQQQQHQAQQAQSQAHYGPPGGGQGPPPPP 684

Human  1010 H-------PPQPGQIPGPGSMMPGQHMPGRMIPTVAANIHPSGSGPTPP------GMPPMPGNIL 1061
            .       ||.|||..||    ||.:.|.:..|...|..:|   ||.||      |.||.|..:.
 Worm   685 QGQQYYGGPPPPGQPYGP----PGGYPPQQQRPPYQAQPYP---GPPPPQQQRGYGYPPPPQPVF 742

Human  1062 GPRVPLTAPNGMYPPPPQQQPPPPPPADGVPPPP 1095
            ... |...|.|..||||..|..|.....|...||
 Worm   743 SGH-PYQQPYGQMPPPPHGQYQPQQQQGGPMGPP 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCC1	NP_003065.3	MarR-like, BRCT and chromo domains module. /evidence=ECO:0000255|PROSITE-ProRule:PRU01376	28..302
		SWIRM-assoc_2	32..445	CDD:465143	27/101 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..439		24/95 (25%)
		RSC8	444..>710	CDD:227584	177/283 (63%)
		SWIRM-assoc_3	706..772	CDD:465145	29/65 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..860		18/114 (16%)
		SWIRM-assoc_1	883..954	CDD:465142	52/70 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	956..1028		31/173 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1041..1105		21/61 (34%)
swsn-1	NP_001256907.1	RSC8	33..509	CDD:227584	278/566 (49%)
		SWIRM-assoc_3	354..419	CDD:465145	30/69 (43%)