DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DLK2 and dlk2

DIOPT Version :9

Sequence 1:	XP_005249365.1	Gene:	DLK2 / 65989	HGNCID:	21113	Length:	476	Species:	Homo sapiens
Sequence 2:	XP_031757707.1	Gene:	dlk2 / 100493472	XenbaseID:	XB-GENE-6049768	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	199/408 - (48%)
Similarity:	239/408 - (58%)	Gaps:	45/408 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    87 LLGPALTMPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCE 151
            ||...|||....|.| |..:..:|.......:||:||..|||.||.|..|..|||||||:|..||
Frog    38 LLRTLLTMLCWFRLL-LPAVSLLLALHWVSAQADECSERCDLYHGHCDQDRMCRCDPGWDGEFCE 101

Human   152 RCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 216
            .|||||||.||:|||||||:||:||||||||||.|:|....||||.|:|:.|..||:.|:|...|
Frog   102 DCVRMPGCAHGSCHQPWQCMCHNGWAGKFCDKDLHLCNHSDPCQNQGECLIDHDGEFSCICPEPF 166

Human   217 HGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 281
            :||.||.|.||||:||.||.|||.|.|..|||..||||||.|:.|..|:::||||||||||||||
Frog   167 YGRTCELKRGPCEKAGFPCLNGGSCHDRSGFANTFTCRCLAGYTGELCQMDVDDCLMRPCANGAT 231

Human   282 CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPV 346
            |.||||||||.||.||.|||||||:||||.:|||...||.|||.|::|.||.|:.||:||:.:|.
Frog   232 CHDGINRFSCECPSGFQGRFCTINIDDCAGQPCQNNGRCYDRVGDYECYCPEGFMGKSCEIPIPK 296

Human   347 P--DPPTTVDTPLGPT----SAVVVPATGPAPHSAGAGLL---RISVKEVVRRQEAGLGEPSLVA 402
            |  |......|....|    |.|..|   |...:...|..   .|||||||.:.|..|....||.
Frog   297 PTWDEELRASTKDSETAHERSRVTRP---PLVRTLDTGRKSQGTISVKEVVMQVERSLTTLQLVL 358

Human   403 LVVFGALTAALVLATVLLTL----RAWRRGVCPPGPCCYPAPHY-----APACQDQECQVSMLPA 458
            ::|||.:|...:.:|:.:.|    |:.|:           ..|:     |...|.||||.|
Frog   359 VIVFGTITGIAIFSTITVVLVYRNRSARQ-----------TAHHGYGLSAAKTQYQECQGS---- 408

Human   459 GLPLPRDLPPEPGKTTAL 476
                    .|:..|||.|
Frog   409 --------SPDHRKTTEL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLK2	XP_005249365.1	EGF_CA	182..222	CDD:238011	19/39 (49%)
		EGF_CA	267..303	CDD:238011	30/35 (86%)
		EGF_CA	305..341	CDD:238011	20/35 (57%)
dlk2	XP_031757707.1	EGF_CA	138..172	CDD:238011	15/33 (45%)
		EGF_CA	<184..215	CDD:238011	18/30 (60%)
		EGF_CA	217..253	CDD:238011	30/35 (86%)
		EGF_CA	255..291	CDD:238011	20/35 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I37653
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I9181
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161653at32523
OrthoFinder	1	1.000	-	-		FOG0008418
OrthoInspector	1	1.000	-	-		oto149811
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060