DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMARCA4 and STH1

DIOPT Version :10

Sequence 1:NP_001122321.1 Gene:SMARCA4 / 6597 HGNCID:11100 Length:1679 Species:Homo sapiens
Sequence 2:NP_012140.1 Gene:STH1 / 854680 SGDID:S000001388 Length:1359 Species:Saccharomyces cerevisiae


Alignment Length:1346 Identity:507/1346 - (37%)
Similarity:711/1346 - (52%) Gaps:315/1346 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   362 DPVEILQEREYRLQARIAHRIQELENLPGSLA-------------GDL-------RTKATIELKA 406
            ||     :.|.|:.|||::||.|||.||.:|.             .||       :.||.:|||:
Yeast   188 DP-----DTEIRISARISNRINELERLPANLGTYSLDDCLEFITKDDLSSRMDTFKIKALVELKS 247

Human   407 LRLLNFQRQLRQEVV----------VCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQK 461
            |:||..|:.:||:::          :...||:....|.......|||....:..|:.|:||:||.
Yeast   248 LKLLTKQKSIRQKLINNVASQAHHNIPYLRDSPFTAAAQRSVQIRSKVIVPQTVRLAEELERQQL 312

Human   462 IEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKER 526
            :|:.:|.|..|.:.:|||:...|:.:....|...:..:..:..|:.|...|::::|..||..|:|
Yeast   313 LEKRKKERNLHLQKINSIIDFIKERQSEQWSRQERCFQFGRLGASLHNQMEKDEQKRIERTAKQR 377

Human   527 MRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAEN 591
            :..|.:.|||.|.||:||.||.|:..||:||:.::.:|:|.||                      
Yeast   378 LAALKSNDEEAYLKLLDQTKDTRITQLLRQTNSFLDSLSEAVR---------------------- 420

Human   592 AEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSD 656
                              :|.::  .|::|                          |.||.|.:|
Yeast   421 ------------------AQQNE--AKILH--------------------------GEEVQPITD 439

Human   657 SEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVS 721
                                        ||::|                                
Yeast   440 ----------------------------EEREK-------------------------------- 444

Human   722 QALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKT 786
                   ..||.|||.:.|::|||.:::|.|.||:||::||||:||||||:||||||||||||||
Yeast   445 -------TDYYEVAHRIKEKIDKQPSILVGGTLKEYQLRGLEWMVSLYNNHLNGILADEMGLGKT 502

Human   787 IQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSG 851
            ||:|:|||||.|.|:..||||:||||||::||..||:|||||:..:.|||:|..|.:...|:|.|
Yeast   503 IQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLEFEKWAPSLNTIIYKGTPNQRHSLQHQIRVG 567

Human   852 KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQN 916
            .|:|||||||||||||.:|:|..|.:||:||||||||...||:..::.:|....||:||||||||
Yeast   568 NFDVLLTTYEYIIKDKSLLSKHDWAHMIIDEGHRMKNAQSKLSFTISHYYRTRNRLILTGTPLQN 632

Human   917 KLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTG--EKVDLNEEETILIIRRLHKVLRPFLLRR 979
            .||||||||||:||.||.|..|||.|||.|||.||  ||::|.||||:|||||||||||||||||
Yeast   633 NLPELWALLNFVLPKIFNSAKTFEDWFNTPFANTGTQEKLELTEEETLLIIRRLHKVLRPFLLRR 697

Human   980 LKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRK 1044
            ||||||..||:|||.||||.:|.||:.||:.|.....|.. |:..:...|||.|.|.|.||||||
Yeast   698 LKKEVEKDLPDKVEKVIKCKLSGLQQQLYQQMLKHNALFV-GAGTEGATKGGIKGLNNKIMQLRK 761

Human  1045 ICNHPYMFQHIEESFSEHLGFTGGIVQ----GLD-LYRASGKFELLDRILPKLRATNHKVLLFCQ 1104
            |||||::|..:|           |:|.    ..| |:|.:||||||||:|||.:|:.|:||:|.|
Yeast   762 ICNHPFVFDEVE-----------GVVNPSRGNSDLLFRVAGKFELLDRVLPKFKASGHRVLMFFQ 815

Human  1105 MTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSAD 1169
            ||.:|.||||:...:..||:||||:||.|:|..:|..||.|.|:||.|||||||||||||||:||
Yeast   816 MTQVMDIMEDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDYFCFLLSTRAGGLGLNLQTAD 880

Human  1170 TVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMF 1234
            ||||||:|||||||||||||||||||:||||:|||.|.:||||.||..|..||::|.||||||.|
Yeast   881 TVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVILERAMQKLDIDGKVIQAGKF 945

Human  1235 DQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVP-D 1298
            |.||::.|:.|||:.::|.|                          .|.|       ::|:.. |
Yeast   946 DNKSTAEEQEAFLRRLIESE--------------------------TNRD-------DDDKAELD 977

Human  1299 DETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRK------PRLMEEDELPSWIIKDDAEVERL 1357
            |:.:|..:||..:|..||.::|.:|..:|..:.|.:      |||::.||||. :.::|.|..  
Yeast   978 DDELNDTLARSADEKILFDKIDKERMNQERADAKAQGLRVPPPRLIQLDELPK-VFREDIEEH-- 1039

Human  1358 TCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKKI------------------------------ 1392
             .::|:.:..|| .|.:|.|.|.|.|||:|:|:.:                              
Yeast  1040 -FKKEDSEPLGR-IRQKKRVYYDDGLTEEQFLEAVEDDNMSLEDAIKKRREARERRRLRQNGTKE 1102

Human  1393 ------------------------------TGKDIHDTAS-SVARGLQFQRGLQFCTRASK--AI 1424
                                          |..|...||| |..|..:.:|.:...|...|  ..
Yeast  1103 NEIETLENTPEASETSLIENNSFTAAVDEETNADKETTASRSKRRSSRKKRTISIVTAEDKENTQ 1167

Human  1425 EEGTLEE-----IEEEVRQKK------SSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRP 1478
            ||.|.:|     :||||:...      |..|:|:...........:|...:.|.:..::|...:.
Yeast  1168 EESTSQENGGAKVEEEVKSSSVEIINGSESKKKKPKLTVKIKLNKTTVLENNDGKRAEEKPESKS 1232

Human  1479 PAEKLSPNPPNLTKK-------MKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKP 1536
            ||:|.:........|       ::|:|:.:.:..|.......:.:|.:|||:::.|:|:::|.||
Yeast  1233 PAKKTAAKKTKTKSKSLGIFPTVEKLVEEMREQLDEVDSHPRTSIFEKLPSKRDYPDYFKVIEKP 1297

Human  1537 VDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDS 1582
            :....|.:..:|..|::|.::.:.:..:.:||:.:|.|||.:|.|:
Yeast  1298 MAIDIILKNCKNGTYKTLEEVRQALQTMFENARFYNEEGSWVYVDA 1343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCA4NP_001122321.1 DEGH box 881..884 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1254..1299 4/45 (9%)
SnAC 1322..1389 CDD:464219 24/72 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1432..1492 13/65 (20%)
Bromo_SNF2L2 1490..1596 CDD:99947 25/100 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1596..1679
KIKL. /evidence=ECO:0000269|PubMed:29567837 1628..1631
Necessary for interaction with SS18L1/CREST. /evidence=ECO:0000250 1..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..177
Med15 42..>222 CDD:312941
QLQ 171..205 CDD:462622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..352
Smc <364..>570 CDD:440809 74/235 (31%)
HSA 460..532 CDD:214727 19/71 (27%)
RNA-binding region which is sufficient for binding to lncRNA Evf2. /evidence=ECO:0000250|UniProtKB:Q3TKT4 462..728 48/265 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..610 0/32 (0%)
BRK 612..656 CDD:197800 6/43 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 647..699 8/51 (16%)
DEXHc_SMARCA4 731..981 CDD:350820 166/251 (66%)
PLN03142 750..>1232 CDD:215601 309/488 (63%)
Sufficient for interaction with DLX1. /evidence=ECO:0000250|UniProtKB:Q3TKT4 837..916 43/78 (55%)
STH1NP_012140.1 HSA 312..378 CDD:462194 16/65 (25%)
PLN03142 370..>955 CDD:215601 360/731 (49%)
SnAC 1006..1069 CDD:464219 23/67 (34%)
COG5076 <1211..>1359 CDD:227408 31/133 (23%)
Blue background indicates that the domain is not in the aligned region.

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