DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMARCA4 and STH1

DIOPT Version :9

Sequence 1:	NP_001122321.1	Gene:	SMARCA4 / 6597	HGNCID:	11100	Length:	1679	Species:	Homo sapiens
Sequence 2:	NP_012140.1	Gene:	STH1 / 854680	SGDID:	S000001388	Length:	1359	Species:	Saccharomyces cerevisiae

Alignment Length:	1346	Identity:	507/1346 - (37%)
Similarity:	711/1346 - (52%)	Gaps:	315/1346 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   362 DPVEILQEREYRLQARIAHRIQELENLPGSLA-------------GDL-------RTKATIELKA 406
            ||     :.|.|:.|||::||.|||.||.:|.             .||       :.||.:|||:
Yeast   188 DP-----DTEIRISARISNRINELERLPANLGTYSLDDCLEFITKDDLSSRMDTFKIKALVELKS 247

Human   407 LRLLNFQRQLRQEVV----------VCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQK 461
            |:||..|:.:||:::          :...||:....|.......|||....:..|:.|:||:||.
Yeast   248 LKLLTKQKSIRQKLINNVASQAHHNIPYLRDSPFTAAAQRSVQIRSKVIVPQTVRLAEELERQQL 312

Human   462 IEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKER 526
            :|:.:|.|..|.:.:|||:...|:.:....|...:..:..:..|:.|...|::::|..||..|:|
Yeast   313 LEKRKKERNLHLQKINSIIDFIKERQSEQWSRQERCFQFGRLGASLHNQMEKDEQKRIERTAKQR 377

Human   527 MRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAEN 591
            :..|.:.|||.|.||:||.||.|:..||:||:.::.:|:|.||
Yeast   378 LAALKSNDEEAYLKLLDQTKDTRITQLLRQTNSFLDSLSEAVR---------------------- 420

Human   592 AEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSD 656
                              :|.::  .|::|                          |.||.|.:|
Yeast   421 ------------------AQQNE--AKILH--------------------------GEEVQPITD 439

Human   657 SEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVS 721
                                        ||::|
Yeast   440 ----------------------------EEREK-------------------------------- 444

Human   722 QALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKT 786
                   ..||.|||.:.|::|||.:::|.|.||:||::||||:||||||:||||||||||||||
Yeast   445 -------TDYYEVAHRIKEKIDKQPSILVGGTLKEYQLRGLEWMVSLYNNHLNGILADEMGLGKT 502

Human   787 IQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSG 851
            ||:|:|||||.|.|:..||||:||||||::||..||:|||||:..:.|||:|..|.:...|:|.|
Yeast   503 IQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLEFEKWAPSLNTIIYKGTPNQRHSLQHQIRVG 567

Human   852 KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQN 916
            .|:|||||||||||||.:|:|..|.:||:||||||||...||:..::.:|....||:||||||||
Yeast   568 NFDVLLTTYEYIIKDKSLLSKHDWAHMIIDEGHRMKNAQSKLSFTISHYYRTRNRLILTGTPLQN 632

Human   917 KLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTG--EKVDLNEEETILIIRRLHKVLRPFLLRR 979
            .||||||||||:||.||.|..|||.|||.|||.||  ||::|.||||:|||||||||||||||||
Yeast   633 NLPELWALLNFVLPKIFNSAKTFEDWFNTPFANTGTQEKLELTEEETLLIIRRLHKVLRPFLLRR 697

Human   980 LKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRK 1044
            ||||||..||:|||.||||.:|.||:.||:.|.....|.. |:..:...|||.|.|.|.||||||
Yeast   698 LKKEVEKDLPDKVEKVIKCKLSGLQQQLYQQMLKHNALFV-GAGTEGATKGGIKGLNNKIMQLRK 761

Human  1045 ICNHPYMFQHIEESFSEHLGFTGGIVQ----GLD-LYRASGKFELLDRILPKLRATNHKVLLFCQ 1104
            |||||::|..:|           |:|.    ..| |:|.:||||||||:|||.:|:.|:||:|.|
Yeast   762 ICNHPFVFDEVE-----------GVVNPSRGNSDLLFRVAGKFELLDRVLPKFKASGHRVLMFFQ 815

Human  1105 MTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSAD 1169
            ||.:|.||||:...:..||:||||:||.|:|..:|..||.|.|:||.|||||||||||||||:||
Yeast   816 MTQVMDIMEDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDYFCFLLSTRAGGLGLNLQTAD 880

Human  1170 TVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMF 1234
            ||||||:|||||||||||||||||||:||||:|||.|.:||||.||..|..||::|.||||||.|
Yeast   881 TVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVILERAMQKLDIDGKVIQAGKF 945

Human  1235 DQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVP-D 1298
            |.||::.|:.|||:.::|.|                          .|.|       ::|:.. |
Yeast   946 DNKSTAEEQEAFLRRLIESE--------------------------TNRD-------DDDKAELD 977

Human  1299 DETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRK------PRLMEEDELPSWIIKDDAEVERL 1357
            |:.:|..:||..:|..||.::|.:|..:|..:.|.:      |||::.||||. :.::|.|..
Yeast   978 DDELNDTLARSADEKILFDKIDKERMNQERADAKAQGLRVPPPRLIQLDELPK-VFREDIEEH-- 1039

Human  1358 TCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKKI------------------------------ 1392
             .::|:.:..|| .|.:|.|.|.|.|||:|:|:.:
Yeast  1040 -FKKEDSEPLGR-IRQKKRVYYDDGLTEEQFLEAVEDDNMSLEDAIKKRREARERRRLRQNGTKE 1102

Human  1393 ------------------------------TGKDIHDTAS-SVARGLQFQRGLQFCTRASK--AI 1424
                                          |..|...||| |..|..:.:|.:...|...|  ..
Yeast  1103 NEIETLENTPEASETSLIENNSFTAAVDEETNADKETTASRSKRRSSRKKRTISIVTAEDKENTQ 1167

Human  1425 EEGTLEE-----IEEEVRQKK------SSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRP 1478
            ||.|.:|     :||||:...      |..|:|:...........:|...:.|.:..::|...:.
Yeast  1168 EESTSQENGGAKVEEEVKSSSVEIINGSESKKKKPKLTVKIKLNKTTVLENNDGKRAEEKPESKS 1232

Human  1479 PAEKLSPNPPNLTKK-------MKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKP 1536
            ||:|.:........|       ::|:|:.:.:..|.......:.:|.:|||:::.|:|:::|.||
Yeast  1233 PAKKTAAKKTKTKSKSLGIFPTVEKLVEEMREQLDEVDSHPRTSIFEKLPSKRDYPDYFKVIEKP 1297

Human  1537 VDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDS 1582
            :....|.:..:|..|::|.::.:.:..:.:||:.:|.|||.:|.|:
Yeast  1298 MAIDIILKNCKNGTYKTLEEVRQALQTMFENARFYNEEGSWVYVDA 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA4	NP_001122321.1	Necessary for interaction with SS18L1/CREST. /evidence=ECO:0000250	1..282
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..177
		Med15	42..>222	CDD:312941
		QLQ	171..205	CDD:400990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..352
		Smc	<370..>552	CDD:224117	67/211 (32%)
		HSA	460..532	CDD:214727	19/71 (27%)
		RNA-binding region which is sufficient for binding to lncRNA Evf2. /evidence=ECO:0000250\|UniProtKB:Q3TKT4	462..728		48/265 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..610		0/32 (0%)
		BRK	612..654	CDD:400080	5/41 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..699		8/51 (16%)
		DEXHc_SMARCA4	731..981	CDD:350820	166/251 (66%)
		PLN03142	750..>1232	CDD:215601	309/488 (63%)
		Sufficient for interaction with DLX1. /evidence=ECO:0000250\|UniProtKB:Q3TKT4	837..916		43/78 (55%)
		DEGH box	881..884		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1254..1299		4/45 (9%)
		SnAC	1323..1389	CDD:405324	24/71 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1432..1492		13/65 (20%)
		Bromo_SNF2L2	1490..1596	CDD:99947	25/100 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1596..1679
STH1	NP_012140.1	HSA	314..382	CDD:400077	17/67 (25%)
		PLN03142	370..>955	CDD:215601	360/731 (49%)
		SnAC	1006..1069	CDD:405324	23/67 (34%)
		COG5076	<1211..>1359	CDD:227408	31/133 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	373	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	819	1.000	Inparanoid score	I60
Isobase	1	0.950	-	0	Normalized mean entropy	S727
OMA	1	1.010	-	-		QHG52479
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		mtm10217
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1363
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.850