DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMARCA4 and brm

DIOPT Version :9

Sequence 1:	NP_001122321.1	Gene:	SMARCA4 / 6597	HGNCID:	11100	Length:	1679	Species:	Homo sapiens
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1810	Identity:	908/1810 - (50%)
Similarity:	1125/1810 - (62%)	Gaps:	319/1810 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGS--AHSMMGPSPGPPSAGHPIPTQGPGG 63
            |::|.|  ..:|.|.|.   .|||.|....||.|||.|  .|...||..|||..|||    |..|
  Fly     1 MASPSP--ANSPMPPPQ---APSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP----GAYG 56

Human    64 YPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSE 128
            :|..:                                 |..|.|||...|..|.||.....|  .
  Fly    57 HPMQH---------------------------------GPPGQGPPGHHMPPHHQGMIFSKG--P 86

Human   129 HASSPVPASGPSSGPQMSSG-------------PGGAPLDGADPQALGQQN-------------- 166
            |....:|.:||:..|..:.|             |||.|.....|:...|:|
  Fly    87 HMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEK 151

Human   167 --------------RGPTP---FNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQG--KRPMPG 212
                          |..:.   .|.||::.||.||.||::|||.:|:...:|.|:|.  ::|.||
  Fly   152 GLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPG 216

Human   213 MQQQMPTLPPPSVSATGPGPG----------------PGPGPGPGPGPAPPNYSRPHGMGGPNMP 261
                 |.:.||.... ||.||                |.|..|..|..:.|..|.|:   ||.:|
  Fly   217 -----PPIGPPGAPG-GPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPY---GPPVP 272

Human   262 -------PPGP---SGVPPGMPGQPP--GGPPKPWPEGPMANAAAPTSTPQKLIPPQPT------ 308
                   ||.|   .|.|  :|.|||  ||||      |:.....|....|:..||.|.
  Fly   273 GQKMQVAPPPPHMQQGQP--LPPQPPQVGGPP------PIQQQQPPQQQQQQSQPPPPEPHQHQL 329

Human   309 ---GR-----PSPAPPAVPPA--------ASPVMPPQTQSP---GQPAQPAPM--VPLHQKQSRI 352
               |:     ||...|.:|.:        ..|.|||.:|.|   |.|.:..|.  :|: .|.:||
  Fly   330 PNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPM-PKPNRI 393

Human   353 TPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLR 417
            |.:.||.||||:.:|||||.|:.|||:.|:|||:.||.:::.|||.:|.|||:|||:||||||||
  Fly   394 TTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLR 458

Human   418 QEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQH 482
            .|.|.|.||||.||||||.|.|||:|||.|||||.|||||||||:|.||||||||.|:|.::|||
  Fly   459 MEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQH 523

Human   483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKD 547
            .||.:|:||:...::.::.|||..:|||.|||||||.||||||||||||||||||||||||||||
  Fly   524 GKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKD 588

Human   548 KRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKK---KKAENAEGQTPAIGPDGEPLDET 609
            ||||:||.|||||::|||::|:|||..|:.|::::.|:.   ||.....|:  .||     :||.
  Fly   589 KRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGE--YIG-----IDEG 646

Human   610 SQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEES-GSEEEEEEEEEEQ 673
            |.::|:.|.|:...:||.|||.|||....|..||.|:||::..  .|.|:| ||.::.:.:.|||
  Fly   647 SIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWI--DDEEDSCGSNDDHKPKVEEQ 709

Human   674 PQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAV 738
            |.|.:..|    :|.:....|.      ||:.:|..||.: ||||...:      |:||::||.:
  Fly   710 PTATEDAT----DKAQATGNDE------DAKDLITKAKVE-DDEYRTEE------QTYYSIAHTI 757

Human   739 TERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRIN 803
            .|:|.:|:::||||.||:||||||||||||||||||||||||||||||||||:|:||||:.|::.
  Fly   758 HEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVM 822

Human   804 GPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKH 868
            ||:|||||||||.||..||:||||:|..|||||||..||....|:|:.|||||||||||:||||.
  Fly   823 GPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKA 887

Human   869 ILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIF 933
            :||||:|||||:|||||||||||||||||||||:||.|||||||||||||||||||||||||:||
  Fly   888 VLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIF 952

Human   934 KSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKC 998
            |||||||||||||||.|||||:||||||||||||||||||||||||||||||.|||:||||:|||
  Fly   953 KSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKC 1017

Human   999 DMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHL 1063
            ||||||||||:|||:|||||||||||.|.||||.|.|||||:||||:||||:|||||||.:.:|.
  Fly  1018 DMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHT 1082

Human  1064 GFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDG 1128
            | ..|:|.|.||||.||||||||||||||:||||:||||||||..|||:|||..:|.|.||||||
  Fly  1083 G-GHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDG 1146

Human  1129 TTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRI 1193
            ||||||||.||:.||..||:.|:|||||||||||||||:||||:|||||||||||||||||||||
  Fly  1147 TTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRI 1211

Human  1194 GQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDE 1258
            ||:||||||||.|||||||:|||||:||||:|:||||||||||||:..||:.|||.||..::.:|
  Fly  1212 GQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEE 1276

Human  1259 SRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDR 1323
                                            :||:||||||.:|.||||.|||.::|.|||.:|
  Fly  1277 --------------------------------EEENEVPDDEMINMMIARSEEEIEIFKRMDAER 1309

Human  1324 RREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQW 1388
            ::|:......:.||::|.|||.|:.|||.||||...:.:|:.:.|||||.||||||:||||||:|
  Fly  1310 KKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEW 1374

Human  1389 LKKITGKDIHDTASSVARGLQFQRGLQFCTRASKAIEEGT-LEEIEEEVRQKKSSRKRKRDSDAG 1452
            |                                |||::|. .:|.|||...|:..||||
  Fly  1375 L--------------------------------KAIDDGAEFDEEEEEDDSKRKRRKRK------ 1401

Human  1453 SSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVF 1517
                   .|..:.||:|...|:|.|...:|.|      .|:|.||:.||||:  :..||.|||.|
  Fly  1402 -------NRKEESDDDSLILKRRRRQNLDKRS------KKQMHKIMSAVIKH--NQDGRTLSEPF 1451

Human  1518 IQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDS 1582
            ::||||:.||:|||:|::|||.|||.:||.:.||..||:||||.|.||||||.:|.|.||||.||
  Fly  1452 MKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDS 1516

Human  1583 IVLQSVFTSVRQKIE--------KEDDSEGE---------ESEEEEEGEEEGSESE------SRS 1624
            |.||.||...||:|.        ...|:.||         ...::::|.::||:.|      :.:
  Fly  1517 IALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAA 1581

Human  1625 VKVKIKLGRK--------EKAQDRLKGGRRRPS------RGSRAKPVVSDDDSEE 1665
            ||:|:||.:.        .::...:..|....|      :.|:.|..:||||.::
  Fly  1582 VKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDDD 1636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA4	NP_001122321.1	Necessary for interaction with SS18L1/CREST. /evidence=ECO:0000250	1..282		100/356 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..177		54/221 (24%)
		Med15	42..>222	CDD:312941	55/225 (24%)
		QLQ	171..205	CDD:400990	15/36 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..352		58/210 (28%)
		Smc	<370..>552	CDD:224117	127/181 (70%)
		HSA	460..532	CDD:214727	45/71 (63%)
		RNA-binding region which is sufficient for binding to lncRNA Evf2. /evidence=ECO:0000250\|UniProtKB:Q3TKT4	462..728		128/269 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..610		9/35 (26%)
		BRK	612..654	CDD:400080	17/41 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..699		15/52 (29%)
		DEXHc_SMARCA4	731..981	CDD:350820	202/249 (81%)
		PLN03142	750..>1232	CDD:215601	395/481 (82%)
		Sufficient for interaction with DLX1. /evidence=ECO:0000250\|UniProtKB:Q3TKT4	837..916		62/78 (79%)
		DEGH box	881..884		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1254..1299		6/44 (14%)
		SnAC	1323..1389	CDD:405324	34/65 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1432..1492		17/59 (29%)
		Bromo_SNF2L2	1490..1596	CDD:99947	62/105 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1596..1679		21/107 (20%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931	13/29 (45%)
		Drf_FH1	251..390	CDD:283903	42/150 (28%)
		HSA	501..573	CDD:214727	45/71 (63%)
		BRK	649..693	CDD:197800	18/45 (40%)
		PHA02934	687..>824	CDD:165245	76/155 (49%)
		SNF2_N	776..1071	CDD:278600	248/294 (84%)
		DEXDc	793..932	CDD:238005	107/138 (78%)
		Helicase_C	1097..1212	CDD:278689	94/114 (82%)
		SnAC	1304..1375	CDD:291293	37/70 (53%)
		Bromo_SNF2L2	1425..1530	CDD:99947	63/112 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	503	1.000	Domainoid score	I336
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1559	1.000	Inparanoid score	I90
Isobase	1	0.950	-	0	Normalized mean entropy	S727
OMA	1	1.010	-	-		QHG52479
OrthoDB	1	1.010	-	-		D41262at33208
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm41782
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1363
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.860