DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HLTF and CG10445

DIOPT Version :9

Sequence 1:	XP_011511393.1	Gene:	HLTF / 6596	HGNCID:	11099	Length:	1013	Species:	Homo sapiens
Sequence 2:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	1050	Identity:	256/1050 - (24%)
Similarity:	407/1050 - (38%)	Gaps:	290/1050 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    79 NNEMVALQRDPNNPYDKNAIKVNN-VNGNQVGHLKKELAGALAYIMDN-------------KLAQ 129
            :.:..::|...:.|...::.::|| :....|..|  ||:|..|   ||             |.||
  Fly    13 HKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSL--ELSGEYA---DNESAIFVSASEYNEKKAQ 72

Human   130 IEGVVPFGANNAFTMPLHMTFWGKEENRKAVSD--QLKKHGFKLGPAPKTLG------------- 179
            |:.:|    ....||.....  ..|||.....:  .||.|..||....:.||
  Fly    73 IDQLV----QKILTMEQQQR--QLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQ 131

Human   180 -------------------FNLESGWGSGRAGPSYSMPVHAAVQM------TTEQLKTEFDKL-- 217
                               .||.||....|...:     |.|.|.      ..:.|||.::.:
  Fly   132 EIKIEDNSELVDHTEQPKWSNLYSGLNRYRQKAN-----HTAAQFYQHKSNIIDSLKTLYEPIQP 191

Human   218 ---FEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFS 279
               .:||       |.:|| .:...||.||:..|.||..||..|
  Fly   192 RPAIDDL-------EKQPA-LLLVRLLKHQQSCLKWMQFRERQK--------------------- 227

Human   280 EKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGN 344
                   :.||||||||||||||:.||:||.:         |..|..  |:|
  Fly   228 -------ISGGILADDMGLGKTLSMIALILAS---------EETKNR--KRE------------- 261

Human   345 NTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEIETSELP 409
               ||...|:...::...:....:|::.|.|...|.|.      |...||    :..|..|..:.
  Fly   262 ---EKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESG------KEEEQY----EPPEKRTCHVK 313

Human   410 QKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKGACAVEGSKKTDVEER 474
            .|...:.:.:..:..   .||...|:||             .:|.:|.| ....|.....:.||.
  Fly   314 TKKINQFRILDDDDN---DAGDKAVVED-------------EQKDLLAK-TPEPEVFSSDEEEEH 361

Human   475 -------PRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYVYYGPDR--IREPALLSKQDIVLTT 530
                   ...||::||:||:..|..:....:..:. :....::||:|  |...|..| .|:|:|:
  Fly   362 LSNGRYPSANTLVVCPMSVMCQWAHEVASKVAQNA-IRVLTFHGPNRHEIGIEAFRS-YDLVITS 424

Human   531 YNILTHDYGTKGD-SPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSLK 594
            ||::.::....|: |||.::.|.||||||.|.|||.......:|..|.:...|.|||||:||...
  Fly   425 YNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGV 489

Human   595 DLWSLLSFLKLKPFIDREWWHRTIQRPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELP 659
            |:::||.|:.:..|.|.:.|.:.:...:.     |.|||..:||.:.|||||........:..||
  Fly   490 DVFALLRFVNVPNFQDLQQWKKNLNESML-----GHRRLNFIIKPLMLRRTKQKLQASGDMPALP 549

Human   660 ERKVFIQHITLSDEERKIYQSV--------------KNEGRATIGRYFNEGT---VLAHYAD--- 704
            ..|:.:..:.||..|..:||.:              :.:|.:.:..|..|.|   :..|.:|
  Fly   550 SLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERY 614

Human   705 -----------------------VLGLLLRLRQICCHTYL----LTNAVSSNGPSAFSL-GNDTP 741
                                   :|.|||||||.|||..|    |..|:::.......: .:|..
  Fly   615 NEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVE 679

Human   742 EELRKKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCPLCRN 806
            .:|:..::.::.....:.|:::|....||                      .....:.|..:.::
  Fly   680 GQLKMDVLAELDKFDETDSEDDCCDEEDS----------------------TRRDGNFKLEVIKD 722

Human   807 DIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNP----------------- 854
            :|.|:|:    |.:...|....|..|....|     ..||..|..:||
  Fly   723 EIKEENV----PWDSGDDLPTASSFEDQLDS-----ARALKLLNPQNPIFQFIRPSAKLKMVIDK 778

Human   855 --------NIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQ-NTEAGSPT 910
                    |.|.:|.||:.::|:::...|:...:.....:|.:..|:|...::.|. |.|   ..
  Fly   779 LEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNE---KR 840

Human   911 IMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENML 975
            ::||||.||||||||:.|:.:.::|..|||..|.|..||.:|.||.:...|.:::.:|:||:.:.
  Fly   841 VLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIK 905

Human   976 KIQNKKRELA 985
            .:|:.|.|:|
  Fly   906 SLQDCKLEIA 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLTF	XP_011511393.1	HIRAN	60..155	CDD:285949	19/89 (21%)
		DEXDc	238..>320	CDD:214692	28/81 (35%)
		DEXDc	288..>320	CDD:238005	18/31 (58%)
		SNF2_N	472..722	CDD:278600	89/306 (29%)
		DEXDc	<478..588	CDD:238005	39/112 (35%)
		RING	763..808	CDD:238093	4/44 (9%)
		Helicase_C	836..954	CDD:278689	41/143 (29%)
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	236/961 (25%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	114/413 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770