DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCA2 and Mi-2

DIOPT Version :10

Sequence 1:NP_003061.3 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens
Sequence 2:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster


Alignment Length:1785 Identity:433/1785 - (24%)
Similarity:710/1785 - (39%) Gaps:499/1785 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   153 PGALIPGDPQAMSQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGK--RTLPGL 215
            |.|.:..|..|..:||:......             |.        ||..:...:||  :|..|.
  Fly    23 PAAELSNDSDAPLKPNQNDEDDD-------------YD--------PEDSRRKKKGKKRKTRKGE 66

Human   216 QQQQQQQQQQQQQQQ------QQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSG---------- 264
            ::.::::::::.:.:      |..::.:.|.......:.::::|.|....:..||          
  Fly    67 EKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSA 131

Human   265 ----------------------------------PGPELSGP---------------STPQKLPV 280
                                              ..|:::.|               |.|.   :
  Fly   132 FSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPH---I 193

Human   281 PAPGGRPSPAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQE 345
            ...||        ||....:|....||....|.:|        :.||.|..:||..:....:.:|
  Fly   194 QQEGG--------AAGSGGSAGQARSVTGDEPEEP--------RSSRSSRNEKPDDIYEEAVEEE 242

Human   346 REYRLQARIAHRIQELENLPGSLP----PDLRTKATVELKALRLLNFQRQ----LRQEVVACMRR 402
            .|...:.:...|.:......|..|    |.|:         ::||..:::    ..|:......|
  Fly   243 EEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLK---------IKLLGKRKRDSSDEEQDASGASER 298

Human   403 DTTL----------------ETALNSKA-----------------YKRSKRQTLREARMTEKLEK 434
            |:.|                |..::|||                 .|::|.:...:.:...||:|
  Fly   299 DSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKK 363

Human   435 QQKIEQERKRRQKHQEYLNSILQ------------------------------------------ 457
            .:...:......:||:|.....|                                          
  Fly   364 TKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGA 428

Human   458 --------H------AKDFKE----------YHR-----------------------SVAGKIQK 475
                    |      .||..|          ||.                       .:.||.:|
  Fly   429 AEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEK 493

Human   476 LSKAVATWH---------ANTEREQKKETERIEK-----ERMRRLMAE-----DEEGYRKLIDQK 521
                :.||.         .:|.:..|....|:.:     ..|.....|     ..:.:..|:.:.
  Fly   494 ----IITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRS 554

Human   522 KDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDE 586
            ..|:  |.:::..::..:|......:|:.|..|:|.     ..||.::||..|.....:|     
  Fly   555 FQRK--YDMEEPPKFEESLDEADTRYKRIQRHKDKV-----GMKANDDAEVLEERFYKNG----- 607

Human   587 SSQMSDLPVKVTHTETGKVLFGPEAPKAS--QLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEE 649
                    ||.......:|:....|...|  .|..|.|:  .|:          .|.:|||.::.
  Fly   608 --------VKPEWLIVQRVINHRTARDGSTMYLVKWREL--PYD----------KSTWEEEGDDI 652

Human   650 ESSRQETE-----EKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAIS 709
            :..||..:     ..:.....::..|:|..|......|.:.|::..:::.....:...|   .:.
  Fly   653 QGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTT---DLK 714

Human   710 ERVEKQSALLINGT---LKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKR 771
            ::.|.|.|.| .||   |..||::|:.|:...:...::.||||||||||||||:..:..|.:...
  Fly   715 KKYEDQPAFL-EGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGH 778

Human   772 LNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTP----------------AMRRSLVPQLRS 820
            ..||:|:.||||||.||..||:.|||....|:|.|..                |:|.|.|.:||:
  Fly   779 CRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRT 843

Human   821 G--KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTP 883
            .  |||||||:||.|..|...|..|.|..::|||.||:|::..|..::||::.:| .::||||||
  Fly   844 TQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA-YKLLLTGTP 907

Human   884 LQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLR 948
            |||.|.||:.|||||....|.....|:          ||..|:::||.   ::|||::|.|.:||
  Fly   908 LQNNLEELFHLLNFLSRDKFNDLQAFQ----------GEFADVSKEEQ---VKRLHEMLGPHMLR 959

Human   949 RLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEK-DKKGKGGAKTLMNTIMQL 1012
            |||.:|...:|.|.|::::.::||:||..|:      .:||...|. :.|..||:.:|:|.:|.|
  Fly   960 RLKTDVLKNMPSKSEFIVRVELSAMQKKFYK------FILTKNYEALNSKSGGGSCSLINIMMDL 1018

Human  1013 RKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTS 1077
            :|.|||||:|....|......|   |:.....|.:|:||..||.::|.:|:|.|||||:|.|||.
  Fly  1019 KKCCNHPYLFPSAAEEATTAAG---GLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTK 1080

Human  1078 LMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVV 1142
            ::.|:||:.....:.|.|:||......|...:.:||.||:|.|:|||||||||||:||..||||:
  Fly  1081 MLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVI 1145

Human  1143 IFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQK 1207
            |:|||||||.|:||..|||||||.|:|.:.|..|.|||||::...||.|:.:...|::.||..:.
  Fly  1146 IYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKG 1210

Human  1208 SSSHERRAFLQAILE------HEEENEEEDEVPDDETLNQMIARRE---EEFDLFMRMDMDRRRE 1263
            ::..::.  |..||.      .:|:::||....||:.:.:::.|..   ||.:.:....:...:.
  Fly  1211 ANFTKQE--LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKV 1273

Human  1264 DARNPKRKPRLMEEDELPSWIIKDDAE---------VERLTCEEEEEKI---FGRGSRQRRDVDY 1316
            .:...|.     ||:|..:.|||.|||         :.|...|:.:|.:   .|:|.|.|:.|:|
  Fly  1274 ASYATKE-----EEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNY 1333

Human  1317 SD-----ALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVE-------KAKKRRG 1369
            :|     |.|.:      :|.|.::...|.   ..:.....|:|...:|.:       |||:|..
  Fly  1334 TDGGVVAADTTR------DDSNWQDNGSEY---NSEYSAGSDEDGGDDDFDDQNGAERKAKRRLE 1389

Human  1370 RPPAEKLSPNPPKL-------------TKQMNAIIDTVINY----KDRCNVEKV----------- 1406
            |....   |.||.|             .:|..:.::.::.|    :|..|.:.:           
  Fly  1390 RRDDR---PLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERN 1451

Human  1407 --------------PSNSQLEI-------EGNSSGRQLSEVFIQLPSRKELPE------YY---E 1441
                          |.....|.       ||.|....|:.:.:....||::.|      ||   |
  Fly  1452 FKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPE 1516

Human  1442 LIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKI 1506
            ||.||.      |.:|:       .|::||..|.......|::.|....:|:.  ....:|....
  Fly  1517 LILKPC------EPVRS-------ALKQDVAALEAPPTGGNVDKSATTSNSVT--PATSAAPSPA 1566

Human  1507 AKEEESEDESNEEEEEED-----------EEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR 1560
            ...|:.||:..:.|:|:|           |:|:|.:.|...|      |.:...::..|..:|:.
  Fly  1567 PASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDV------KQENPVEEAAGDTKPSD 1625

Human  1561 GKAKPVVSDFDSDEEQDEREQSEGSGTDDE 1590
            .:.|..|:..:..||..:.|..|...|:::
  Fly  1626 AEVKTEVAKTEPKEETKDPEVKEEPKTEEK 1655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCA2NP_003061.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
Atrophin-1 <46..>450 CDD:460830 60/404 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176 6/22 (27%)
QLQ 173..207 CDD:462622 3/33 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334 23/186 (12%)
HSA 436..508 CDD:214727 19/174 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592 9/40 (23%)
BRK 589..632 CDD:462196 9/44 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 8/49 (16%)
DEXHc_SMARCA2 701..951 CDD:350821 108/270 (40%)
PLN03142 720..>1202 CDD:215601 214/503 (43%)
DEGH box 851..854 2/2 (100%)
SnAC 1259..1326 CDD:464219 22/83 (27%)
Bromodomain 1333..>1419 CDD:445827 22/141 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383 11/45 (24%)
Bromo_SNF2L2 1382..1506 CDD:99947 31/181 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590 21/94 (22%)
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357 3/52 (6%)
TNG2 <282..422 CDD:227367 17/139 (12%)
PHD1_CHD_II 380..422 CDD:277006 2/41 (5%)
PHD2_CHD_II 440..482 CDD:277007 5/41 (12%)
CD1_tandem_CHD3-4_like 487..557 CDD:349314 11/73 (15%)
CD2_tandem_CHD3-4_like 610..664 CDD:349309 13/65 (20%)
PLN03142 720..>1234 CDD:215601 223/539 (41%)
DUF1087 <1292..1334 CDD:461922 11/41 (27%)
CHDII_SANT-like 1380..1517 CDD:461920 24/139 (17%)
CHDCT2 1757..1902 CDD:462358
Blue background indicates that the domain is not in the aligned region.

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