DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCA2 and Iswi

DIOPT Version :9

Sequence 1:NP_001276325.1 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens
Sequence 2:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster


Alignment Length:1182 Identity:346/1182 - (29%)
Similarity:521/1182 - (44%) Gaps:333/1182 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   509 EDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGG 573
            |.|..:...|:..:.||..:||:||:         ::.|....:||...|.:.|.||.::     
  Fly    30 EKEAEFDNKIEADRSRRFDFLLKQTE---------IFTHFMTNSAKSPTKPKGRPKKIKD----- 80

Human   574 ESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEES 638
                                                                       .|.|:.
  Fly    81 -----------------------------------------------------------KDKEKD 86

Human   639 DSDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYT 703
            .:|:.....|:|    |.||.:..|..::|:...||                             
  Fly    87 VADHRHRKTEQE----EDEELLAEDSATKEIFRFDA----------------------------- 118

Human   704 VAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLME 768
                       ..|.:.:|.::.||::||.||:|||.|.:|||||||||||||:|||:|:.||..
  Fly   119 -----------SPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKH 172

Human   769 HKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQ-LRSGKFNVLLTTYEY 832
            .|...||:::|||.|||.||..||.||.||:..:...|....|.:.:.. |..|:::|.:|:||.
  Fly   173 FKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEM 237

Human   833 IIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNF 897
            .|::|.:..|..|:|:::||.||:||...||:::|. .:....|:|:|||||||.|.||||||||
  Fly   238 CIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILR-EFKTANRLLITGTPLQNNLHELWALLNF 301

Human   898 LLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKV 962
            |||.:|.|...|::|||....:..:          .:|.|||.||:||||||||.|||.:|..|.
  Fly   302 LLPDVFNSSEDFDEWFNTNTCLGDD----------ALITRLHAVLKPFLLRRLKAEVEKRLKPKK 356

Human   963 EYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEE 1027
            |..|...:|.:|:..|..:..|.|.:.:|:.|.:|.:     |.|.:|||||..||||:|...|.
  Fly   357 EMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMR-----LQNILMQLRKCTNHPYLFDGAEP 416

Human  1028 ----SFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAF 1088
                :...||.|:            |||..:||::||||:....|||:|.|||.::.|:|||..:
  Fly   417 GPPYTTDTHLVYN------------SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHW 469

Human  1089 RNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQD 1153
            ||:.|.||||.|..|||...:::||...|..|:|:|||||||||:||..||.|:|:||||||..|
  Fly   470 RNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMD 534

Human  1154 LQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAG-MFDQKSSSHERRAFL 1217
            |||.||||||||:.:|||.||.|.::|||||:..|:.||.:|:.|||.| :.|.:|:...:...|
  Fly   535 LQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEML 599

Human  1218 QAIL--EHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRL--MEED 1278
            ..|.  .::..:.:|.::.|::                  :|:...|.:|:..::|..|  :.|.
  Fly   600 NIIRFGANQVFSSKETDITDED------------------IDVILERGEAKTAEQKAALDSLGES 646

Human  1279 ELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRL 1343
            .|.::.:..:.|....:..:.|      |...|          |||.|.|:  ||.      :..
  Fly   647 SLRTFTMDTNGEAGTSSVYQFE------GEDWR----------EKQKLNAL--GNW------IEP 687

Human  1344 KKRKRRRN--VD---KDPAKEDVEKAKKRRGRPPAEKLSPN----PPKLTKQMNAIIDTVINYKD 1399
            .||:|:.|  ||   ::..:....||.| ..|||.:.:..:    ||:|.:    ::|..|.|..
  Fly   688 PKRERKANYAVDAYFREALRVSEPKAPK-APRPPKQPIVQDFQFFPPRLFE----LLDQEIYYFR 747

Human  1400 RCNVEKVPSNSQLEIEGNSSGRQ----------------------LSEVFIQLPSR--------- 1433
            :....|||.|::|..:.....|:                      ||:.|.....|         
  Fly   748 KTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKAN 812

Human  1434 --------------------KELPEYYEL------------------------------IRKPVD 1448
                                :|:.||..:                              |:|.:|
  Fly   813 EKYGRDDIDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALD 877

Human  1449 ---------FKKIKERIRNHKYRSLGDLEKDVMLLC--HNAQTFNLEGSQIYEDSIVLQSVFKSA 1502
                     |.:::.:..|:|.::..::| |..|:|  |.   ...:...:||:   |::..:::
  Fly   878 QKMSRYRAPFHQLRLQYGNNKGKNYTEIE-DRFLVCMLHK---LGFDKENVYEE---LRAAIRAS 935

Human  1503 RQ-------KIAKEEESEDESN------EEEEEEDEEESESEAKSVKVKIKLNKKDDKGR-DKGK 1553
            .|       |.....|.:...|      |.|..|.||:..:|.|         ||..||. ..|.
  Fly   936 PQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKK---------KKAPKGSVSAGS 991

Human  1554 GKKRPNRGKAKP 1565
            |....|.....|
  Fly   992 GSASSNTPAPAP 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCA2NP_001276325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
Forkhead_N 40..174 CDD:254796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176
QLQ 173..207 CDD:286024
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334
HSA 436..508 CDD:214727
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592 6/40 (15%)
BRK 590..632 CDD:197800 0/41 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 10/44 (23%)
SNF2_N 727..1022 CDD:278600 135/295 (46%)
DEXDc 744..883 CDD:238005 62/139 (45%)
DEGH box 851..854 2/2 (100%)
Helicase_C 1049..1164 CDD:278689 66/114 (58%)
SnAC 1259..1326 CDD:291293 13/68 (19%)
Bromodomain 1333..>1419 CDD:295360 24/94 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383 14/47 (30%)
Bromo_SNF2L2 1382..1506 CDD:99947 32/222 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590 17/67 (25%)
IswiNP_523719.1 DBINO <30..67 CDD:290603 11/45 (24%)
SNF2_N 131..411 CDD:278600 135/295 (46%)
DEXDc 148..287 CDD:238005 62/139 (45%)
HELICc 422..553 CDD:238034 74/142 (52%)
HAND 697..796 CDD:286232 22/103 (21%)
SANT 797..838 CDD:197842 3/40 (8%)
SANT 799..838 CDD:238096 2/38 (5%)
SLIDE 853..965 CDD:286233 18/118 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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