DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCA2 and Chd1

DIOPT Version :10

Sequence 1:NP_003061.3 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens
Sequence 2:NP_001245851.1 Gene:Chd1 / 33505 FlyBaseID:FBgn0250786 Length:1900 Species:Drosophila melanogaster


Alignment Length:1718 Identity:443/1718 - (25%)
Similarity:675/1718 - (39%) Gaps:467/1718 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    48 PGPPSVSHPMPTMGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSP 112
            ||..:::....::||.:  |:...:.....|           |.||..|:|.....   ....|.
  Fly    17 PGCRALNESANSIGSDE--QDDTREEANGTD-----------HSGSGSGSGSSGSD---SDSDSS 65

Human   113 MDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPG--DPQAMSQPN------- 168
            ....|.|..||.      ||..|..::|   .||....:|..:...|  |.|..|..:       
  Fly    66 SGNSSDGRSSPE------PEDKSLSVAG---FPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDS 121

Human   169 ----RGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQ 229
                .|||        ..|.|.:.....:...|.||                           |.
  Fly   122 DSDAEGPS--------DQRNQSINNANTSSSLPKPE---------------------------QN 151

Human   230 QQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAA 294
            :::..:.:..||||....:..:...:..|.:..|.     |..|..::........|.:..||.|
  Fly   152 EEEDNETEAGQQQPASDASADESSDSSANVSPTSS-----SSSSEEEEEDYRPKRTRQARKPPTA 211

Human   295 AQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQ 359
            |:....|        |||..........:..      :.....|.|...|:|             
  Fly   212 AEKSKKA--------PAPKNKKKTWDSDESD------ESEDSDDEVSTAQKR------------- 249

Human   360 ELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKR-SKRQTL 423
                         :..||.....|.    |:|.|:.|......|:..:.|....|.:| ....:.
  Fly   250 -------------KPAATTSRSKLA----QQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSY 297

Human   424 REARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTE 488
            :||...|..:.:..:|                       .||..|.|          ||..|..|
  Fly   298 KEASEDEATDSEDLLE-----------------------FEYDESQA----------ATTAATAE 329

Human   489 REQKKET-ERIEKERMRR---------LMAEDEEGY--RKLIDQKK----DRRLAYLLQQTD-EY 536
            .|:|.|| |||..:|..:         :.|.:|.|:  ....|:|:    :....:|::... .|
  Fly   330 EEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSY 394

Human   537 VANLTNLVWEHK---QAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVT 598
            :.|    .||.:   :...||..||.....||.:|.|.....| ||  |.||...          
  Fly   395 IHN----TWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYA-GP--EDIDYFE---------- 442

Human   599 HTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKILLD 663
                            .||:...|:...|....|..::.|..|   :..||...:.::.      
  Fly   443 ----------------CQLELQHELLKSYNNVDRIIAKGSKPD---DGTEEYLCKWQSL------ 482

Human   664 PNSEEVSEKDAKQII----ETAKQDVDDEYS----------MQYSARGSQSYYTVAHAISERVEK 714
            |.:|...| ||..::    ..|:|..|.|.|          ::|..:.|            |::.
  Fly   483 PYAESTWE-DAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFS------------RIKN 534

Human   715 QSALLING-TLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLI 778
            |...|.:| ||:.||:.||.|::..:....:.|||||||||||||||..:..|.:...|.||:|.
  Fly   535 QPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLC 599

Human   779 IVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQL-------RSGKFNVLLTTYEYIIKD 836
            :|||||::.|..|||.|||.:..::|.| ....|.|:.|.       :..|||.:|||||.::||
  Fly   600 VVPLSTMTAWQREFDLWAPDMNVVTYLG-DIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKD 663

Human   837 KHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPT 901
            |..|..::|..::|||.||:||....|.:.|. .:....|:|:|||||||.|.||||||:|::|.
  Fly   664 KQFLGTLQWAALLVDEAHRLKNDDSLLYKSLK-EFDTNHRLLITGTPLQNSLKELWALLHFIMPD 727

Human   902 IFKSCSTFE-QWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYV 965
            .|.:...|| |..||            |::.   ..|||:.|.|::|||:||:||..||.|||.:
  Fly   728 KFDTWENFEVQHGNA------------EDKG---YTRLHQQLEPYILRRVKKDVEKSLPAKVEQI 777

Human   966 IKCDMSALQKILYRHMQAKGILLTDGSEKDKKGK-GGAKTLMNTIMQLRKICNHPYMFQHIEESF 1029
            ::.:|::|||..|:.      :||...:..:||| |...|.:|.:::|:|.|||..:   |..|.
  Fly   778 LRVEMTSLQKQYYKW------ILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAAL---IRPSE 833

Human  1030 AEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYL 1094
            .|.:|....... ..|.:.|||..|||::|.:|:.|.||||:|.||..::.::.||...|:|.:.
  Fly   834 FELMGLQQDEAL-QTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQ 897

Human  1095 RLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDR 1159
            ||||:.|.|.|...|..||..|||.|.|||||||||||:||..||||:||||||||..|||||.|
  Fly   898 RLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQAR 962

Human  1160 AHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ------AGMFDQKSSSHE------ 1212
            ||||||:|:|.:.||.|..||||:|:..||.|:.:|..|||      ..:.|:..:.|.      
  Fly   963 AHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPF 1027

Human  1213 RRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEE 1277
            .:..|.|||:...|...:||             :|.:.||...:|...||.:.||  ..|.:..:
  Fly  1028 NKDDLSAILKFGAEELFKDE-------------QEHDDDLVCDIDEILRRAETRN--EDPEMPAD 1077

Human  1278 DELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDV--------DYSDALTEKQWLRAIEDGNL 1334
            |.|.::.:...|..|    ||..:.:    |:|.::.        |:.|.:.| .:.:||:|...
  Fly  1078 DLLSAFKVASIAAFE----EEPSDSV----SKQDQNAAGEEDDSKDWDDIIPE-GFRKAIDDQER 1133

Human  1335 EEMEEEVRLKKRKR------------------RRNVDKDPAKEDVEKAK---------KRRGRPP 1372
            .:..|::.|..|::                  ::..|......|.|...         ::||||.
  Fly  1134 AKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPT 1198

Human  1373 -AEKLS-----------------PNPPKLTKQMNAI-IDTVINYK-------------DRC---- 1401
             .||::                 |.|   ..:|.|| .|..:..|             |||    
  Fly  1199 MKEKITGFTDAELRRFIRSYKKFPAP---LHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFL 1260

Human  1402 -----------NVEKVPSNSQ--------LEIEGNSSG-----------RQLSEVFIQLPSRKEL 1436
                       ..::.|...|        :::.|.|..           :.|:|:...:|..::.
  Fly  1261 HEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQ 1325

Human  1437 PEYYELIRKP---VDFKKIKERIRNHKYRSLGDLEKDVMLLC-------HNAQTFNLEGSQIYED 1491
            ..:....|.|   ||:                .:|:|..|||       .:.:...|:.:....|
  Fly  1326 WSFNIKTRAPVFDVDW----------------GIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTD 1374

Human  1492 SIVLQSVFKSARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKK 1556
            .|:|                  :::.:.:.::.:..:|...|.:|..::|.|...: |.:.....
  Fly  1375 KILL------------------NDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQR-RQRRPRAS 1420

Human  1557 RPNRGKAKPVVSDFDSDEEQDEREQSEG 1584
            |.|..||....:....|.:..:.|.:.|
  Fly  1421 RANDAKAASQSASSTIDAKPHDGEDAAG 1448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCA2NP_003061.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71 5/22 (23%)
Atrophin-1 <46..>450 CDD:460830 72/415 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176 21/93 (23%)
QLQ 173..207 CDD:462622 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334 18/121 (15%)
HSA 436..508 CDD:214727 17/81 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592 14/40 (35%)
BRK 589..632 CDD:462196 4/42 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 8/44 (18%)
DEXHc_SMARCA2 701..951 CDD:350821 103/258 (40%)
PLN03142 720..>1202 CDD:215601 220/497 (44%)
DEGH box 851..854 2/2 (100%)
SnAC 1259..1326 CDD:464219 16/74 (22%)
Bromodomain 1333..>1419 CDD:445827 25/167 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383 12/83 (14%)
Bromo_SNF2L2 1382..1506 CDD:99947 28/181 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590 13/79 (16%)
Chd1NP_001245851.1 CD1_tandem_CHD1-2_like 339..421 CDD:349313 17/85 (20%)
CD2_tandem 454..508 CDD:349306 13/63 (21%)
PLN03142 531..>1066 CDD:215601 238/574 (41%)
CDH1_2_SANT_HL1 1205..1298 CDD:465731 14/95 (15%)
DUF4208 1521..1610 CDD:464035
Blue background indicates that the domain is not in the aligned region.

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