Protein Alignment SMARCA1 and Hel89B

DIOPT Version :10

• Sequence 1: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Alignment Length: 791
• Identity: 237/791 - (29%)
• Similarity: 346/791 - (43%)
• Gaps: 143/791 - (18%)

Human     6 AAVAATVAAADATATI-VVIEDEQPGPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSFQLKLA 69
            |...|.:|..||..|: .|:.|..|.....::......|.||.          |:.||..|:|:.
  Fly  1213 ARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI----------ERVVSRLQIKVV 1267

Human    70 -----AKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPR 129
                 ...|......||        |.:.|    |..|..||:.:|       ..||:.|  ..:
  Fly  1268 PYIVLLVVPLLGAMSDP--------DESVR----LLSTHCFANLVQ-------LMPLDGK--TEQ 1311

Human   130 IKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWL 194
            :|.|..|:         |:|...|..:.|...:...|..:...:|..      ||.||..|:|||
  Fly  1312 LKSDPLQA---------RKTRDREFLDYLFNPKSIPNYKVPVPISVE------LRCYQQAGINWL 1361

Human   195 ISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPG----PHMVLVPKSTLHNWMNEFKRWV 255
            ..|.:..::|||.|:||||||||||.:|.....:|....    |.:|:.|.:...:|:.|.::::
  Fly  1362 WFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFL 1426

Human   256 PS---LRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIK 317
            ..   ||.:.:.|....|.....|  :..:.::.|.||:.|.|:...|...|:.|.|:||.|.||
  Fly  1427 DQGSVLRPLHYYGFPVGREKLRSD--IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIK 1489

Human   318 NEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DT 374
            |.|:|.|:.::..|:.:||:|:|||:|||:.|||:|.:||:|....:...|...|        |.
  Fly  1490 NGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDA 1554

Human   375 KNCLGDQK----LVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWY----TKIL 431
            |:...:|:    .:|.||..:.||||||:|.||.|.||||....:...||.:|...|    .|.|
  Fly  1555 KSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHL 1619

Human   432 MKDIDVLNSSGKMD--------KMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSG-- 486
            ...:|.|..|....        |..:...|..|:..||||.|...........|.:..:|||.
  Fly  1620 KDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLD 1684

Human   487 -----------KMVVLDKLLAKLKEQGS--RVLIFSQMTRLLDILEDYCMWR---GYEYCRLDGQ 535
                       |.::||..:....|..|  |.|||.|:..:|||:|...:.|   ...|.||||.
  Fly  1685 DIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGS 1749

Human   536 TPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQV 600
            .|..:|:|            .:..||: :.|..:.:|:|..||||:||..||.||..:.||||..
  Fly  1750 VPASQRQD------------IVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMK 1801

Human   601 DLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEM 665
            |||||||||||||||.|.|:||||.|::||:|:...:.|:...:.|:.            |:...
  Fly  1802 DLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVS------------AENAS 1854

Human   666 LQMIRHGATHVFASKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFE 730
            ||.:  |.:.:|             .:...|:.|.||......:...|...:....||.....:.
  Fly  1855 LQTM--GTSQIF-------------DLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWS 1904

Human   731 GEDYREKQKLG 741
            ...|.|:..||
  Fly  1905 EHQYEEEYDLG 1915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		12/61 (20%)
		PLN03142	87..1069	CDD:215601	217/704 (31%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	183/527 (35%)