Protein Alignment SMARCA1 and Mi-2

DIOPT Version :10

• Sequence 1: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 1252
• Identity: 350/1252 - (27%)
• Similarity: 535/1252 - (42%)
• Gaps: 306/1252 - (24%)

Human    30 GPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSF----------------QLKLAAKAP----- 73
            |||||                 ||.|.....|..:                :::|....|
  Fly   507 GPSTS-----------------KGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRS 554

Human    74 ---KSEKEMDPEYEEKM-KAD-RAKRFEFLLKQTELFAH----FIQPSAQKSPTSP--------L 121
               |.:.|..|::||.: :|| |.||.:....:..:.|:    .::....|:...|        :
  Fly   555 FQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVI 619

Human   122 NMKLGR-------------PRIKK------DEKQSLISAGDY----------------------- 144
            |.:..|             |..|.      |:.|.|..|.||
  Fly   620 NHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKG 684

Human   145 RHRRTEQEEDEE------LLSESRKTSNVCIRFEVSPSYVKGG--PLRDYQIRGLNWLISLYENG 201
            |..:.:.|:||:      .....:.|:::..::|..|::::|.  .|..|||.|:|||...:..|
  Fly   685 RKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQG 749

Human   202 VNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGD 266
            ::.|||||||||||:||:..|..|....:..||.:|.||.|||.||..||:.|.|....|.::||
  Fly   750 IDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGD 814

Human   267 KDARAAFIRDEMMPGE-----------------WDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAH 314
            ||:||....:|:...|                 ::|.:||||::..:.:......|..||:||||
  Fly   815 KDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAH 879

Human   315 RIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLG 379
            |:|:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|..   :.
  Fly   880 RLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD---VS 941

Human   380 DQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKM 444
            .::.|:|||.:|.|.:|||:||||.|::|.|.|..:.:.||.||:::|..||.|:.:.|||....
  Fly   942 KEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGG 1006

Human   445 DKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGS 503
            ....|:||:|.|:|||||||||..|      ..|..|..:. :...:||:|:|.|:|.:||.|..
  Fly  1007 GSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS-LTKAAGKLVLLSKMLKQLKAQNH 1070

Human   504 RVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKF 568
            |||||||||::||||||:.....|:|.|:||......|:            |||:.||||.:.:|
  Fly  1071 RVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQ------------EAIDRFNAPGAQQF 1123

Human   569 IFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIV 633
            :|:|||||||||||||:||.||:|||||||..|:||..|||||||...|.::|.:|.|:||||:.
  Fly  1124 VFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVT 1188

Human   634 ERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESE----LTDEDITTILE 694
            :.|:.|:.|..:|::.|  :..:.....|:|:..::|.|...:|...:.|    ..|:.:..:|:
  Fly  1189 QVAKRKMMLTHLVVRPG--MGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLD 1251

Human   695 RG----EKKTAEMNERL-----------QKMGESSLRNFRMDIEQS-------LYKFEGEDYREK 737
            |.    |:|.:..||.|           ::..|......:.|.|.|       |.:...|.::|.
  Fly  1252 RTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQED 1316

Human   738 --QKLGMVEWIEPPKRERK-ANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFEL 799
              :.||      ..||.|| .||            ::..:..|.......|.||
  Fly  1317 VGRSLG------KGKRVRKQVNY------------TDGGVVAADTTRDDSNWQD----------- 1352

Human   800 LEKEILYYRKTIGYKVPR-----NPDIPNPALAQREEQKKIDGAE--PLTPEETEEKEKLLTQGF 857
               ....|...  |....     :.|..:...|:|:.:::::..:  ||.|........:...||
  Fly  1353 ---NGSEYNSE--YSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGF 1412

Human   858 TNWTKRDFNQFIKANEKYGRDDIDN-----IAREVEGKSPEEVMEYSAVFWERCNE--------- 908
               ..|....|:.|..:||....|.     :.|::.|||......|.::|.....|
  Fly  1413 ---NARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETF 1474

Human   909 ---------------------------LQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAP 946
                                       :|:.|.|.......|..::....::.||...:|..:||
  Fly  1475 ADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAP 1539

Human   947 FHQLRI------------------------QYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEE 987
            .....:                        :.|..|.|:..:|:|        |...::..|.:|
  Fly  1540 PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKD--------KTSAEKSEVKQE 1596

Human   988 LRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMSQKRK 1052
                 :.|.:.:....:|....:| :...:|     :..:.|::......:.|..||.|   :.|
  Fly  1597 -----QEAEEDKKPGDVKQENPVE-EAAGDT-----KPSDAEVKTEVAKTEPKEETKDP---EVK 1647

Human  1053 AESATESSGKKDVKKVK 1069
            .|..||...|:.|...|
  Fly  1648 EEPKTEEKEKEKVDDKK 1664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		13/75 (17%)
		PLN03142	87..1069	CDD:215601	333/1169 (28%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861		5/31 (16%)
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	11/66 (17%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	11/53 (21%)
		PLN03142	720..>1234	CDD:215601	226/531 (43%)
		DUF1087	<1292..1334	CDD:461922	14/59 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	23/139 (17%)
		CHDCT2	1757..1902	CDD:462358