DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCA1 and Mi-2

DIOPT Version :9

Sequence 1:NP_001269803.1 Gene:SMARCA1 / 6594 HGNCID:11097 Length:1070 Species:Homo sapiens
Sequence 2:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster


Alignment Length:1252 Identity:350/1252 - (27%)
Similarity:535/1252 - (42%) Gaps:306/1252 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    30 GPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSF----------------QLKLAAKAP----- 73
            |||||                 ||.|.....|..:                :::|....|     
  Fly   507 GPSTS-----------------KGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRS 554

Human    74 ---KSEKEMDPEYEEKM-KAD-RAKRFEFLLKQTELFAH----FIQPSAQKSPTSP--------L 121
               |.:.|..|::||.: :|| |.||.:....:..:.|:    .::....|:...|        :
  Fly   555 FQRK
YDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVI 619

Human   122 NMKLGR-------------PRIKK------DEKQSLISAGDY----------------------- 144
            |.:..|             |..|.      |:.|.|..|.||                       
  Fly   620 NHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKG 684

Human   145 RHRRTEQEEDEE------LLSESRKTSNVCIRFEVSPSYVKGG--PLRDYQIRGLNWLISLYENG 201
            |..:.:.|:||:      .....:.|:::..::|..|::::|.  .|..|||.|:|||...:..|
  Fly   685 RKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQG 749

Human   202 VNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGD 266
            ::.|||||||||||:||:..|..|....:..||.:|.||.|||.||..||:.|.|....|.::||
  Fly   750 IDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGD 814

Human   267 KDARAAFIRDEMMPGE-----------------WDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAH 314
            ||:||....:|:...|                 ::|.:||||::..:.:......|..||:||||
  Fly   815 KDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAH 879

Human   315 RIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLG 379
            |:|:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|..   :.
  Fly   880 RLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD---VS 941

Human   380 DQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKM 444
            .::.|:|||.:|.|.:|||:||||.|::|.|.|..:.:.||.||:::|..||.|:.:.|||....
  Fly   942 KEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGG 1006

Human   445 DKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGS 503
            ....|:||:|.|:|||||||||..|      ..|..|..:. :...:||:|:|.|:|.:||.|..
  Fly  1007 GSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS-LTKAAGKLVLLSKMLKQLKAQNH 1070

Human   504 RVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKF 568
            |||||||||::||||||:.....|:|.|:||......|:            |||:.||||.:.:|
  Fly  1071 RVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQ------------EAIDRFNAPGAQQF 1123

Human   569 IFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIV 633
            :|:|||||||||||||:||.||:|||||||..|:||..|||||||...|.::|.:|.|:||||:.
  Fly  1124 VFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVT 1188

Human   634 ERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESE----LTDEDITTILE 694
            :.|:.|:.|..:|::.|  :..:.....|:|:..::|.|...:|...:.|    ..|:.:..:|:
  Fly  1189 QVAKRKMMLTHLVVRPG--MGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLD 1251

Human   695 RG----EKKTAEMNERL-----------QKMGESSLRNFRMDIEQS-------LYKFEGEDYREK 737
            |.    |:|.:..||.|           ::..|......:.|.|.|       |.:...|.::|.
  Fly  1252 RTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQED 1316

Human   738 --QKLGMVEWIEPPKRERK-ANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFEL 799
              :.||      ..||.|| .||            ::..:..|.......|.||           
  Fly  1317 VGRSLG------KGKRVRKQVNY------------TDGGVVAADTTRDDSNWQD----------- 1352

Human   800 LEKEILYYRKTIGYKVPR-----NPDIPNPALAQREEQKKIDGAE--PLTPEETEEKEKLLTQGF 857
               ....|...  |....     :.|..:...|:|:.:::::..:  ||.|........:...||
  Fly  1353 ---NGSEYNSE--YSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGF 1412

Human   858 TNWTKRDFNQFIKANEKYGRDDIDN-----IAREVEGKSPEEVMEYSAVFWERCNE--------- 908
               ..|....|:.|..:||....|.     :.|::.|||......|.::|.....|         
  Fly  1413 ---NARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETF 1474

Human   909 ---------------------------LQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAP 946
                                       :|:.|.|.......|..::....::.||...:|..:||
  Fly  1475 ADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAP 1539

Human   947 FHQLRI------------------------QYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEE 987
            .....:                        :.|..|.|:..:|:|        |...::..|.:|
  Fly  1540 PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKD--------KTSAEKSEVKQE 1596

Human   988 LRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMSQKRK 1052
                 :.|.:.:....:|....:| :...:|     :..:.|::......:.|..||.|   :.|
  Fly  1597 -----QEAEEDKKPGDVKQENPVE-EAAGDT-----KPSDAEVKTEVAKTEPKEETKDP---EVK 1647

Human  1053 AESATESSGKKDVKKVK 1069
            .|..||...|:.|...|
  Fly  1648 EEPKTEEKEKEKVDDKK 1664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCA1NP_001269803.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..82 13/75 (17%)
PLN03142 87..1069 CDD:215601 333/1169 (28%)
DEAH box 311..314 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..849 6/31 (19%)
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335
PHD1_CHD_II 380..422 CDD:277006
PHD2_CHD_II 440..482 CDD:277007
CHROMO 490..558 CDD:237991 11/67 (16%)
CHROMO 615..667 CDD:214605 10/51 (20%)
SNF2_N 734..1028 CDD:278600 127/296 (43%)
DEXDc 751..907 CDD:238005 60/155 (39%)
Helicase_C 1053..1167 CDD:278689 70/125 (56%)
DUF1087 <1292..1337 CDD:283996 14/62 (23%)
DUF1086 1380..1517 CDD:283992 23/139 (17%)
CHDCT2 1756..1927 CDD:285336
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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