Protein Alignment SMARCA1 and Chd3

DIOPT Version :10

• Sequence 1: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Alignment Length: 860
• Identity: 283/860 - (32%)
• Similarity: 422/860 - (49%)
• Gaps: 167/860 - (19%)

Human    50 TEKGEKKKE--------------------------KNVSSFQLKLAAKAPKSEKEMDPEYEEKMK 88
            |.||||::|                          ..|:|||.:...:.|..| |:|.  ::...
  Fly   104 TSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLE-ELDD--QDGNL 165

Human    89 ADRAKRF----EFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDEKQSLISAGDYRHRRT 149
            .:|..|:    |:||.| .:..|..:|:.            |...:.|..:.|      |.....
  Fly   166 HERFYRYGIKPEWLLVQ-RVINHSEEPNG------------GTMYLVKWRELS------YNDSSW 211

Human   150 EQEEDE-----------ELLSESRK---------TSNVCIRFEVSPSYVK--GGPLRDYQIRGLN 192
            |:|.|.           :.|..|.|         |.::..::|..|.::|  |..|..:||.|::
  Fly   212 ERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVS 276

Human   193 WLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPS 257
            ||...:..|:..|||||||||||:||:..|..|....:..||.::.||.|||.||..|.:.|.|.
  Fly   277 WLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPE 341

Human   258 LRVICFVGDKDARAAF--------------IRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYL 308
            |..:.:||.|.|||..              :|:.....:::|.:||||.:..:.:......|..|
  Fly   342 LYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAAL 406

Human   309 VIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD 373
            |:|||||:::.:||...|:.:::...:||||||||||||.||:.|||||....||....|.:.|.
  Fly   407 VVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFT 471

Human   374 TKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVL 438
            .   :..::.|:|||.:|:|.:|||:|.||.||:|||.|..:.:.||.||:::|..||.|:...|
  Fly   472 D---VSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKAL 533

Human   439 NSSGKMDKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDEHIVSNSGKMVVLDKLLAK 497
            |..|......||||:|.|||||||||||..|      .|...|.... :...|||:.:|.|:|.:
  Fly   534 NQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSS-LTKASGKLDLLSKMLKQ 597

Human   498 LKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNA 562
            ||....|||:|||||::|::||.:....||:|.|:||....:.|:            :||:.||.
  Fly   598 LKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQ------------KAIDRFND 650

Human   563 PNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNT 627
            |.|..|:|:|||||||||||||:||.||::||||||..|:||..||||:||||.|.::|.:|.|:
  Fly   651 PVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNS 715

Human   628 VEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESE---LTDEDI 689
            |||||::.|:.|:.|..:|::.|  :...:...:|:|:..::|.|...:|...:||   ..|:.:
  Fly   716 VEERIMQVAKHKMMLTHLVVRPG--MGGMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAV 778

Human   690 TTILERG----EKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPK 750
            ..:|:|.    |:|.:..||.|.                   .|:...|..|:           .
  Fly   779 ADLLDRTNRGIEEKESWANEYLS-------------------SFKVASYATKE-----------D 813

Human   751 RERKANYAVDA------YFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRK 809
            .|...:|..||      |:...:..|:||:||..:...|.:..|.:            .|:...|
  Fly   814 HEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVE------------SIMGKGK 866

Human   810 TIGYKVPRNPDIPNP 824
            .|..::..:...|:|
  Fly   867 RIRKEIDYSNQYPSP 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		14/57 (25%)
		PLN03142	87..1069	CDD:215601	269/797 (34%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127	9/41 (22%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	13/72 (18%)
		PLN03142	266..>768	CDD:215601	216/519 (42%)