DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMARCA1 and brm

DIOPT Version :9

Sequence 1:	NP_001269803.1	Gene:	SMARCA1 / 6594	HGNCID:	11097	Length:	1070	Species:	Homo sapiens
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1206	Identity:	349/1206 - (28%)
Similarity:	526/1206 - (43%)	Gaps:	315/1206 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    48 AATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELF------- 105
            |..|:.:||:::.:...:::      :...|.:..|.:.:...:.||..|||.||:.:
  Fly   550 ANAEREQKKEQERIEKERMR------RLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQM 608

Human   106 ---------------------------------------------AHFIQPSAQKSPTSP----- 120
                                                         .|.::....|..|..
  Fly   609 VKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPML 673

Human   121 ------LNMKLGRPRIKKDEKQSLISAGDYRHRRTEQE--------------------------- 152
                  |||..|...| .||:.|..|..|::.:..||.
  Fly   674 KHLHRWLNMHPGWDWI-DDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAK 737

Human   153 -EDEELLSESRKTSNVC--IRFEV--SPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGL 212
             ||:|..:|.:...::.  |..:|  ..|.:..|.|::|||:||.||:|||.|.:||||||||||
  Fly   738 VEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGL 802

Human   213 GKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDE 277
            |||:|||:|:.||...:.:.||::::||.|||.||:.||::|.|::.|:.:.|....| ..::::
  Fly   803 GKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGR-RLLQNQ 866

Human   278 MMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVR-EFKSTNRLLLTGT 341
            |...:::|.:|:||.|||:|:|..|..|:|::|||.||:||...||::::. .:.:..|||||||
  Fly   867 MRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGT 931

Human   342 PLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQK----------LVERLHAVLKPFLL 396
            ||||.|.|||||||||||.:|.|...|:.||:.......:|          ::.|||.||:||||
  Fly   932 PLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLL 996

Human   397 RRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSS-----GKMDKMRLLNILMQL 456
            ||:|.:||..||.|.|..|...:|.:||..|..:..|.:.:.:.|     ||.....|:|.::||
  Fly   997 RRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQL 1061

Human   457 RKCCNHPYLFDGAEPGPPYTTDEH-IVSN------SGKMVVLDKLLAKLKEQGSRVLIFSQMTRL 514
            ||.||||::|...|......|..| :||.      |||..:||::|.|||....|||:|.|||:.
  Fly  1062 RKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQC 1126

Human   515 LDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAGGL 579
            :.|:|||..||.:.|.||||.|..|:|            .|.:..|||..|..|:|:||||||||
  Fly  1127 MTIIEDYLGWRQFGYLRLDGTTKAEDR------------GELLRKFNAKGSDVFVFLLSTRAGGL 1179

Human   580 GINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDS 644
            |:||.:||.|:::||||||..||||.||||||||:..|||.||:|.|:|||||:..|..||.:|.
  Fly  1180 GLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDE 1244

Human   645 IVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDED-ITTILERGEKKTAEMNERLQ 708
            .|||.| :.||:|....:::.||.|.|...:. ..:|:|:.|:: |..::.|.|::.....
  Fly  1245 KVIQAG-MFDQKSTGSERQQFLQTILHQDDNE-EEEENEVPDDEMINMMIARSEEEIEIFK---- 1303

Human   709 KMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAVDAYFREALRVSEPK 773
                      |||.|:   |.|.|:..             |.|||              .:.|.:
  Fly  1304 ----------RMDAER---KKEDEEIH-------------PGRER--------------LIDESE 1328

Human   774 IPKAPRPPKQPNVQDFQFFPPRLFELLEKEIL----YYRKTIGYKVPRNPDIPNPALAQREEQKK 834
            :|.. .......|:.|.      ::..|..||    ..||.:.|         ..:|.::|..|.
  Fly  1329 LPDW-LTKDDDEVERFH------YQYDEDTILGRGSRQRKEVDY---------TDSLTEKEWLKA 1377

Human   835 IDGAEPLTPEETEEKEK------------------LL----TQGFTNWTKRDFNQFIKANEKYGR 877
            ||.......||.|:..|                  :|    .|.....:|:..::.:.|..|:.:
  Fly  1378 IDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQ 1442

Human   878 D----------------------------DIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEK 914
            |                            ||..|.:.:|.....::.|....|.:.|..
  Fly  1443 DGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQN------ 1501

Human   915 IMAQIERGEARI--QRRISIKKALDAKIARYKAPFHQLRIQYGTSKGK--------NYTEEEDRF 969
              |||...||.:  ...|:::|.......|..|......:..|.:.|:        |...::|.
  Fly  1502 --AQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDD- 1563

Human   970 LICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERE 1034
                    |.|..:..||:.              ..|..|::.:.:.|..::
  Fly  1564 --------GGDDGSDDEEIA--------------TTSAAAVKMKLKLNKSLA------------- 1593

Human  1035 RAEKKKRATKTPMSQKRKAESATESSGKKDVKKVKS 1070
                  .|..||........|...::.||..::.:|
  Fly  1594 ------SAPATPTQSSSNVSSGAATTSKKQTRRKRS 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..82		5/33 (15%)
		PLN03142	87..1069	CDD:215601	342/1164 (29%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..849		8/29 (28%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	4/28 (14%)
		BRK	649..693	CDD:197800	9/44 (20%)
		PHA02934	687..>824	CDD:165245	47/137 (34%)
		SNF2_N	776..1071	CDD:278600	134/295 (45%)
		DEXDc	793..932	CDD:238005	63/139 (45%)
		Helicase_C	1097..1212	CDD:278689	66/126 (52%)
		SnAC	1304..1375	CDD:291293	23/116 (20%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/112 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910