Protein Alignment SMARCA1 and CG4049

DIOPT Version :10

• Sequence 1: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Alignment Length: 1239
• Identity: 257/1239 - (20%)
• Similarity: 419/1239 - (33%)
• Gaps: 499/1239 - (40%)

Human    32 STSQEEGAAAAATEATAATEKGEKKKEKNVSSFQ-------LKLAAKAPKSEKEMDPEYEEKMKA 89
            :::.|:.||.......||.||......||:....       ..|||:..:||:......::|...
  Fly   174 NSAGEDQAANKKLSMAAAEEKKNSHLRKNIRDVMNENNLDTTTLAAQREESERLARVAGQQKSMR 238

Human    90 DRAKR------FEFL-LKQTELFAHFIQPSAQKSPTS---PLNMKLGRPRIK------KDEKQSL 138
            :..|:      |..| |.::|    .|:..|..:|..   |::.    |..:      .|...|.
  Fly   239 EIQKQVVHKQIFRILQLDESE----GIESCAVANPVEHHPPVDF----PEEEIASDTFDDSNSSS 295

Human   139 ISAG---DYRHR------------------------RTEQEEDEELLSESRKTSNVCIRFE---- 172
            :|.|   |..|:                        ..|:|||:|.|:||...:|..:..:
  Fly   296 LSGGSIEDVLHKGASVQPSEVVTIDDSSDDDCILLSEEEEEEDDEDLNESDDATNSGMHVKDIYN 360

Human   173 ----------------------VSPSYVKGGPLRDYQIRGLNWLISLYEN------------GVN 203
                                  ::|...|  .::.:||.|:.:   ||:|            |..
  Fly   361 VPDENGQVVVNMAHPEGEETLYLAPQIAK--VIKPHQIGGVRF---LYDNIIESTRRYNKSSGFG 420

Human   204 GILADEMGLGKTLQTIALLG-YLKH--YRNIPGPHMVLVPKSTLHNWMNEFKRWVP--------- 256
            .|||..||||||||.::... :|:|  .:.:    :.::|.:||.||::||..|:|
  Fly   421 CILAHSMGLGKTLQVVSFCDIFLRHTSAKTV----LCVMPINTLQNWLSEFNMWIPRYSTDSNVR 481

Human   257 ----------------------------------------SLRVICFVGDKDARAAFIRDEMMPG 281
                                                    .|..:..|..:..:.:.||.:.|..
  Fly   482 PRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLALKLVKTRKRKGSVIRPDGMDS 546

Human   282 EWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNN 346
            ..|:....||.::|...       ..::.||.|||||..:.:|..::|.::..|::|||.|||||
  Fly   547 SSDLMNLVYEALVKPGP-------DLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNN 604

Human   347 LHELWALLNFLLPDVFNSADDFDSWFD----TKNCL----GDQKLVER----LHAVLKPFLLRRI 399
            |.|.|.:::|:.|:...:..:|.:.|:    ...|:    .|.||:..    ||::|..|:.||.
  Fly   605 LLEYWCMVDFVRPNYLGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRRS 669

Human   400 KTDVEKSLPPKKEIKIYLGLSKMQREWY---------TK------------------------IL 431
            .|.::.:||.|.|..|.:.::..||:.|         ||                        .|
  Fly   670 HTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMTDVVRTKAFPNPLKAFAVCCKIWNHPDVLYNFL 734

Human   432 MK---DIDV--------------------------------LNSSG----------KMDKMRLLN 451
            .|   |:|:                                :|.||          |.:...|.|
  Fly   735 KKCETDLDLEIDEEVTKGAATPIVEPSADSSLSLASPLEKKINGSGDPINSIETFSKAENQTLFN 799

Human   452 I-------------------------------------------LMQLRKC-------------- 459
            |                                           ::....|
  Fly   800 IPASSDLNAKYLNKSPSFYDEKPEPLNYGSFGSEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSN 864

Human   460 ----------------------------CNHPYLFDGAEPGPP---------------------- 474
                                        |::..|.:|...|.|
  Fly   865 FESITGSSEIVDLDTNEIKTVETTIQAPCSNNQLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKK 929

Human   475 --------------YTTD------EHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILE 519
                          :..|      ..::|||.||.:...:|.:....|.|:|:|||....|::||
  Fly   930 LLKSKQRNEEFSCSWAVDLMKNYVSGLISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLE 994

Human   520 DYC----------MW-RGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLS 573
            .|.          :| :...|.||||.|..:|||            ..:..||| ||:..:|::|
  Fly   995 VYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQERE------------RLVNEFNA-NSNVKLFLIS 1046

Human   574 TRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEI 638
            ||||.|||||..|:.||::|:.|||..|.||:.|.:|.||.||..|:|::.|..:|::|.:| :|
  Fly  1047 TRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDR-QI 1110

Human   639 KLRLDSIVIQQG---RLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDITTI---LERGE 697
            |        :||   |::|:                      .:.|:.|:.:|||.:   .:..|
  Fly  1111 K--------KQGMSDRIVDE----------------------CNPEAHLSMKDITNLCQDYDSDE 1145

Human   698 KKTAEMNER---LQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAV 759
            ....|:|:.   |.|.|..|                    .|..|.|....  .|....|:|..
  Fly  1146 DTVEEVNKSTGDLSKPGSPS--------------------EEGSKPGSANM--SPNASNKSNNG- 1187

Human   760 DAYFREALRVSEPKIPKAP----RPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPD 820
                 ....:.:...||:|    ..|.:....|.|.....:..::...:..:|    :.|.:.|.
  Fly  1188 -----PTKPLDDQNTPKSPNGASHSPIKTEKNDGQEHAVHVDGIINTILDMHR----HCVTKEPF 1243

Human   821 IPNPALAQREEQKKIDGAEPLTPEETEEKEK--LLTQGFT------NW---------TKRDFNQF 868
            :....|..::: :|:..||......:.|.||  .:.|.||      |:         ..:..||.
  Fly  1244 MHESLLVDQKD-RKLSQAEKRQAHRSYELEKKAAVNQRFTYAPAKMNYKIVNNDGTVITKPMNQQ 1307

Human   869 IKAN 872
            ||.|
  Fly  1308 IKTN 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		14/56 (25%)
		PLN03142	87..1069	CDD:215601	242/1177 (21%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861		10/46 (22%)
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	67/275 (24%)
		HepA	<392..1121	CDD:440319	171/764 (22%)