DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMARCA1 and Iswi

DIOPT Version :9

Sequence 1:	NP_001269803.1	Gene:	SMARCA1 / 6594	HGNCID:	11097	Length:	1070	Species:	Homo sapiens
Sequence 2:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster

Alignment Length:	1049	Identity:	739/1049 - (70%)
Similarity:	863/1049 - (82%)	Gaps:	55/1049 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    47 TAATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQP 111
            |||.|..|:...:..|.     ||.:...|||  .|::.|::|||::||:|||||||:|.||:..
  Fly     6 TAAVEATEENSNETTSD-----AATSSSGEKE--AEFDNKIEADRSRRFDFLLKQTEIFTHFMTN 63

Human   112 SAQKSPTSPLNMKLGRP-RIKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSP 175
            || ||||.|    .||| :||..:|:.  ...|:|||:||||||||||:|...|..: .||:.||
  Fly    64 SA-KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLAEDSATKEI-FRFDASP 120

Human   176 SYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVP 240
            :|:|.|.:||||||||||:|||||||:|||||||||||||||||:|||||||::|..|||:|:||
  Fly   121 AYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVP 185

Human   241 KSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHW 305
            ||||.||:||||:|.||||.:|.:||:|.|..||||.:||||||||||||||.|:||||||||:|
  Fly   186 KSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNW 250

Human   306 RYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDS 370
            |||||||||||||||||||||:||||:.||||:||||||||||||||||||||||||||::|||.
  Fly   251 RYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDE 315

Human   371 WFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDI 435
            ||:|..||||..|:.|||||||||||||:|.:|||.|.||||:||::|||||||:||||:|:|||
  Fly   316 WFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDI 380

Human   436 DVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKE 500
            ||:|.:||::||||.|||||||||.||||||||||||||||||.|:|.|||||.:|||||.||:|
  Fly   381 DVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQE 445

Human   501 QGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNS 565
            |||||||||||||:||||||||.||.|.|||||||||||:|            ...|:.||..||
  Fly   446 QGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDR------------NRQIQEFNMDNS 498

Human   566 SKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEE 630
            :||:|||||||||||||||:|||||:||||||||:|||||||||||||||.||||||||::||||
  Fly   499 AKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEE 563

Human   631 RIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDITTILER 695
            :||||||:|||||.:|||.|||:|.:||:|.|:|||.:||.||..||:|||:::|||||..||||
  Fly   564 KIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILER 628

Human   696 GEKKTAEMNERLQKMGESSLRNFRMDIE-----QSLYKFEGEDYREKQKLGMV-EWIEPPKRERK 754
            ||.||||....|..:||||||.|.||..     .|:|:|||||:||||||..: .||||||||||
  Fly   629 GEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERK 693

Human   755 ANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNP 819
            |||||||||||||||||||.||||||||||.|||||||||||||||::||.|:|||:|||||:|.
  Fly   694 ANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNT 758

Human   820 DIPNPAL-AQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNI 883
            ::.:.|. .|||||:|||.|||||.||.:|||.||:||||.||||||||||||||||||||||||
  Fly   759 ELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNI 823

Human   884 AREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFH 948
            |::||||:||||:||:|||||||.||||||:||.||||||.:||||:|||||||.|::||:||||
  Fly   824 AKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFH 888

Human   949 QLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQ 1013
            |||:|||.:|||||||.|||||:|||||:|||:||||||||..:|.:||||||||||||||:|.|
  Fly   889 QLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQ 953

Human  1014 RRCNTLISLIEKENMEIEERERAEKKKRATK-------------TP-------MSQKRKAESATE 1058
            |||||||:|||:||:|:||:|||||||:|.|             ||       .|||||:|....
  Fly   954 RRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVAT 1018

Human  1059 SSGKKDVKK 1067
            ||..|..||
  Fly  1019 SSNSKKKKK 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..82		11/34 (32%)
		PLN03142	87..1069	CDD:215601	726/1009 (72%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..849		16/30 (53%)
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	22/39 (56%)
		SNF2_N	131..411	CDD:278600	221/279 (79%)
		DEXDc	148..287	CDD:238005	110/138 (80%)
		HELICc	422..553	CDD:238034	105/142 (74%)
		HAND	697..796	CDD:286232	74/98 (76%)
		SANT	797..838	CDD:197842	35/40 (88%)
		SANT	799..838	CDD:238096	33/38 (87%)
		SLIDE	853..965	CDD:286233	87/111 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157854
Domainoid	1	1.000	469	1.000	Domainoid score	I458
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55711
Inparanoid	1	1.050	1488	1.000	Inparanoid score	I103
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54891
OrthoDB	1	1.010	-	-		D144251at33208
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm41112
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2588
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800