Protein Alignment SMARCA1 and Etl1

DIOPT Version :10

• Sequence 1: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 733
• Identity: 235/733 - (32%)
• Similarity: 352/733 - (48%)
• Gaps: 171/733 - (23%)

Human    78 EMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQK-----------SPTSPLNMKLGRPRIK 131
            :.|.|...||...|.|.|:|:.:.:.:....::..::|           |..|.|..||...|:.
  Fly   171 DSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDLRQKLESIRMS 235

Human   132 KD---------EKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVS----------PSY 177
            .|         .||:.::|               :||   |.:|:..|.|.:          |..
  Fly   236 GDLLNYAQELINKQNTVAA---------------ILS---KCNNMVSRLEKAISNGAGIVEQPKL 282

Human   178 VKGG-PLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPK 241
            :..| .|.||||.|||||..:::..:|||||||||||||:|.||.|.|||........|:::||.
  Fly   283 LSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPS 347

Human   242 STLHNWMNEFKRWVPSLRVICFVGDKD----ARAAFIRDEMMPGEWDVCVTSYEMV---IKEKSV 299
            |||.||..|..||.|.|.|..:.|.:|    .|..|.:|...  .:||.:|:|.:|   .:|:.:
  Fly   348 STLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFT--GFDVLLTTYHIVGSTPEERKM 410

Human   300 FKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVF-N 363
            |:.....|::.||||.:||..::....:....:..|:|||||||||||.||.:||.|::|..| .
  Fly   411 FRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAK 475

Human   364 SADDFDSWFDTK-NCLGDQ--------KLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGL 419
            |.:|..|.|..| ...|||        ..::|...::|||:|||:|.||.|:||.|..:...:.:
  Fly   476 SIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPM 540

Human   420 SKMQREWYTKILMKDIDVL-NSSGKM---DKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTD-- 478
            |..|:.:|.::    :|.. |:.|::   .:...:.|:|::|:..|||.|.      ..|.||
  Fly   541 SSQQKIYYHEL----VDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLM------RHYFTDAN 595

Human   479 -------------------------------------------------EHIVSNSGKMVVLDKL 494
                                                             ::::.:|||.:.||.|
  Fly   596 LRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTL 660

Human   495 LAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEA 559
            |.|||.:|.|||:|||.|.:|||:|:|...|.:.:|||||.|....|:|            .|..
  Fly   661 LPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQD------------LITD 713

Human   560 FNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLIT 624
            ||. :.|.|:|:|||:|||:||||.:||..:::|.|:||..|.||.||.||:||::||.::|||:
  Fly   714 FNG-DDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLIS 777

Human   625 DNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDI 689
            ::|:||.|:..||.||:|:.         |..||:           .|..|     |.....:.:
  Fly   778 ESTIEEGILMAAEEKLKLEK---------DITSNE-----------KGEVH-----EQRCVVKLL 817

Human   690 TTILERGEKKTAEMNERL 707
            ||.|...:.:..::|..|
  Fly   818 TTALGLDKDQEEQLNNSL 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		1/3 (33%)
		PLN03142	87..1069	CDD:215601	232/724 (32%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	6/40 (15%)
		HepA	<276..795	CDD:440319	198/543 (36%)