Protein Alignment SMARCA1 and Marcal1

DIOPT Version :10

• Sequence 1: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Alignment Length: 850
• Identity: 187/850 - (22%)
• Similarity: 305/850 - (35%)
• Gaps: 229/850 - (26%)

Human    12 VAAADATATIVVIEDEQPGPSTSQEEGAAAAATEATA--------------ATEKGEKKK----- 57
            :|:|.||          .|.||:...||...|....:              .:..||:||
  Fly    28 LASAPAT----------NGKSTTSATGATQHANNGKSNPNQPQAKSPLNFYRSPTGEQKKINRSG 82

Human    58 ----EKNVSSFQLKLAAKAPKSEKEMD----PEYEE------------KMKADRAKRFEFLLK-- 100
                :...|||...|.|....|.:|:.    ..|:.            .:.:|:.|....||.
  Fly    83 PTPGDNKSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLLGNS 147

Human   101 --------QTELFAHFIQPSAQKS----------PTSPLNMKLGRPRIKKDEKQSLISAGDYRHR 147
                    .|..||      ||.|          ...|.....|:.||..      ....||:..
  Fly   148 ITCNLYLISTHRFA------AQTSGYHEQLVTVFKNMPTKCYDGQTRIWS------FDLSDYQSL 200

Human   148 RTEQEEDEELLSES---RKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGV------N 203
            :|...:.:..:..:   :|..::|.:..|.|   :...|...:.:..:.|:...::||      .
  Fly   201 KTHAADLKPYVHMNGIPKKVLDLCGQPPVVP---ERSVLASIEPKLADQLMPFQQDGVCFAIAQK 262

Human   204 G--ILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGD 266
            |  ::.||||||||.|.:|:..|.|.    ..|.:|....||..:|.......:|.: .|.:|
  Fly   263 GRIMICDEMGLGKTYQALAVADYFKD----DWPLLVCTTASTRDSWAKHIMDLLPKV-PIHYV-- 320

Human   267 KDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREF- 330
                .....:::..||..|.:|||.|:.:.:....:..:.:::.||:|.:||.|:|.:...:..
  Fly   321 ----QVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLT 381

Human   331 -KSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKL----------V 384
             ::...:||:|||..:...||:..|..:.....|..:     |.|:.|.|.|..          :
  Fly   382 DQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFME-----FTTRYCDGKQSTFGWDANGQSNL 441

Human   385 ERLHAVLK-PFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMR 448
            |.|..:|. .::|||.|.:|...|..|....:.|..:.:   |......:.:|..|...|..|.|
  Fly   442 EELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV---WTNAETKETLDAFNKELKTAKGR 503

Human   449 LL-NILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMT 512
            .. .||::.                  |.....:.:.:    |...|...:||| .:.:||:...
  Fly   504 ATEEILLRF------------------YARTAEVKTRA----VCAYLKTLVKEQ-KKFIIFAHHR 545

Human   513 RLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAG 577
            .::|.:.|:.......|.|:||||..:.|.|            :::.|...:|.| :.:||.:|.
  Fly   546 VMMDAISDFLSGLKVHYIRIDGQTRSDHRSD------------SVDTFQKKSSCK-VALLSLKAC 597

Human   578 GLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRL 642
            ..||.|.:|::::..:.||||....||..|||||||.|||....||..||.::.|
  Fly   598 NSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDII---------- 652

Human   643 DSIVIQQGRLIDQQSNKLAK----EEMLQMIRHGATHVFASKESELTDEDITTILERGEKKTAEM 703
                   ..::..:...|:|    .|.||...|.|....:.|..|......:|.||      .|.
  Fly   653 -------WNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKIEEYFSPSTSTSLE------PER 704

Human   704 NERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRE--------RKANYAVD 760
            |.                              .||....:...|||::.        .||...:.
  Fly   705 NS------------------------------IKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIA 739

Human   761 AYFRE 765
            |:|.:
  Fly   740 AFFND 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		17/83 (20%)
		PLN03142	87..1069	CDD:215601	165/735 (22%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	12/67 (18%)
		HepA	<233..666	CDD:440319	122/504 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	56/224 (25%)