DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SNAI2 and wor

DIOPT Version :9

Sequence 1:	NP_003059.1	Gene:	SNAI2 / 6591	HGNCID:	11094	Length:	268	Species:	Homo sapiens
Sequence 2:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	185	Identity:	114/185 - (61%)
Similarity:	130/185 - (70%)	Gaps:	17/185 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    97 KDHSGSESPISDEEE-------------RLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQ 148
            :...|....|.|:.|             .:.|..|....:...::.|..|.|:|||:|||:||:|
  Fly   301 RSQPGGSGAIVDQTEFCTDQASALIQAANVASAQSMQKPVGVPRYHCQDCGKSYSTYSGLSKHQQ 365

Human   149 LHCDA----QSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTG 209
            .||.:    |.:|.||||.|||.||||||||||||||||||.|.|||||||||||||||||||||
  Fly   366 FHCPSAEGNQVKKVFSCKNCDKTYVSLGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTG 430

Human   210 EKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGC 264
            ||||||.|||||||||||||||:|||||||||.|..|:|:|||||||.||.:|||
  Fly   431 EKPFSCQHCNRAFADRSNLRAHMQTHSDVKKYSCPTCTKSFSRMSLLAKHLQSGC 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNAI2	NP_003059.1	SNAG domain. /evidence=ECO:0000250	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..117		5/32 (16%)
		SFP1	<101..182	CDD:227516	42/97 (43%)
		C2H2 Zn finger	130..150	CDD:275370	12/19 (63%)
		C2H2 Zn finger	161..181	CDD:275368	17/19 (89%)
		C2H2 Zn finger	187..207	CDD:275368	18/19 (95%)
		zf-H2C2_2	200..223	CDD:404364	21/22 (95%)
		zf-C2H2	213..235	CDD:395048	19/21 (90%)
		C2H2 Zn finger	215..235	CDD:275368	17/19 (89%)
		C2H2 Zn finger	243..259	CDD:275368	10/15 (67%)
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368
		C2H2 Zn finger	317..334	CDD:275368	1/16 (6%)
		zf-C2H2	345..367	CDD:278523	12/21 (57%)
		C2H2 Zn finger	347..367	CDD:275368	12/19 (63%)
		PHA00732	379..>417	CDD:177300	32/37 (86%)
		C2H2 Zn finger	382..402	CDD:275368	17/19 (89%)
		zf-C2H2_8	405..482	CDD:292531	66/76 (87%)
		zf-C2H2	406..428	CDD:278523	19/21 (90%)
		C2H2 Zn finger	408..428	CDD:275368	18/19 (95%)
		zf-H2C2_2	421..444	CDD:290200	21/22 (95%)
		zf-C2H2	434..456	CDD:278523	19/21 (90%)
		C2H2 Zn finger	436..456	CDD:275368	17/19 (89%)
		zf-H2C2_2	448..473	CDD:290200	18/24 (75%)
		C2H2 Zn finger	464..481	CDD:275368	11/16 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159846
Domainoid	1	1.000	52	1.000	Domainoid score	I11527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8461
orthoMCL	1	0.900	-	-		OOG6_107394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3546
SonicParanoid	1	1.000	-	-		X955
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.730