DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMPR2 and put

DIOPT Version :9

Sequence 1:	NP_001195.2	Gene:	BMPR2 / 659	HGNCID:	1078	Length:	1038	Species:	Homo sapiens
Sequence 2:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	175/487 - (35%)
Similarity:	262/487 - (53%)	Gaps:	50/487 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    31 ERLCAFKDPYQQDLGIGESRISHENGTILC----SKGSTCYGLW--EKSKGDINLVKQGCWSHIG 89
            |::|   :..||    .|:||.|      |    .|..:||.||  .::.|.:.:..:||::
  Fly    41 EKMC---NTTQQ----CETRIEH------CKMEADKFPSCYVLWSVNETTGILRIKMKGCFT--- 89

Human    90 DPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIA 154
            |..||:..|||.:..|   :.|...||||....||.|........:.|...|.........:|..
  Fly    90 DMHECNQTECVTSAEP---RQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYI 151

Human   155 LASVSVLAVLIVALCFGYRMLTGDRKQGLH----SMNMMEAAASEPSLDLDNLKLLELIGRGRYG 215
            ....||.:||:|.:  |..:|...|::..|    ..:..|...|.|.|....::|||....||:|
  Fly   152 YIGTSVFSVLMVIV--GMGLLLYRRRKQAHFNEIPTHEAEITNSSPLLSNRPIQLLEQKASGRFG 214

Human   216 AVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVME 280
            .|::..|:.:.||||:|....::::..|.:||::|.|.|.||..|:..::.:   .:.||.|:..
  Fly   215 DVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHM---DKPEYWLIST 276

Human   281 YYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELP--RGDHYKPAISHRDLNSRNVLVKN 343
            |..|||||.||..||..|...||:|.|:..|||:||.|:|  :.|..||:|:|||..|:|||:|:
  Fly   277 YQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKS 341

Human   344 DGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNL-RDCESALKQVDMY 407
            |.|..|:||||:|      :.:||:.......:|||.|||||||||||:|. ||   |..::|:|
  Fly   342 DLTACIADFGLAM------IFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRD---AFLRIDVY 397

Human   408 ALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLA 472
            |.||:.||:..||.  |.| .|.|:|:.|:.|:|..|:.:::|..|..:|.||:...:|:.:. .
  Fly   398 ACGLVLWEMVSRCD--FAG-PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHP-G 458

Human   473 VRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
            :....:|:|:|||.||||||::.|..||.|:|
  Fly   459 LNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMPR2	NP_001195.2	Activin_recp	52..127	CDD:307282	24/80 (30%)
		STKc_BMPR2_AMHR2	207..504	CDD:270956	124/299 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..972
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	32/103 (31%)
		STKc_ACVR2	206..493	CDD:270955	125/301 (42%)
		S_TKc	210..479	CDD:214567	118/284 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820