DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMPR2 and bmpr2

DIOPT Version :9

Sequence 1:	NP_001195.2	Gene:	BMPR2 / 659	HGNCID:	1078	Length:	1038	Species:	Homo sapiens
Sequence 2:	XP_002937761.3	Gene:	bmpr2 / 100494339	XenbaseID:	XB-GENE-479990	Length:	1053	Species:	Xenopus tropicalis

Alignment Length:	1053	Identity:	813/1053 - (77%)
Similarity:	899/1053 - (85%)	Gaps:	30/1053 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     5 LQRPWRVPWLP------------WTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGT 57
            |.|.|::..:.            .:..|::||.|:|::|||||:|||..||..:.||:||.||||
Frog    12 LSRSWKLQDMASNHTLILLILGLHSTFLLATAPATQSEERLCAYKDPNNQDQALSESQISLENGT 76

Human    58 ILCSKGSTCYGLWEKSK-GDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTD 121
            :.|:||:.|:|||||:: |:||||:||||||:.|.::|:||||.|||.||.||||||||||||.|
Frog    77 VKCTKGNICFGLWEKTRDGEINLVRQGCWSHVSDSRDCYYEECAVTTPPPVIQNGTYRFCCCSKD 141

Human   122 LCNVNFTENFPPPDTT---PLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGL 183
            :|||||||||.|.|.|   |.||....:|:.||||||||:||||||||...||||:..|||||||
Frog   142 MCNVNFTENFTPSDPTSASPYSPSGWLHREMTIIIALASISVLAVLIVVFFFGYRIFGGDRKQGL 206

Human   184 HSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYR 248
            ||||::|||.||||||||||||||||||||||:||||||||||||||||||.||||||||::|||
Frog   207 HSMNVLEAATSEPSLDLDNLKLLELIGRGRYGSVYKGSLDERPVAVKVFSFNNRQNFINERSIYR 271

Human   249 VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLA 313
            .||:||||||.||..|||:|:|||:|||||||||.||||.||||:|::||::|||||||||:|||
Frog   272 TPLLEHDNIAHFIAADERITSDGRLEYLLVMEYYANGSLSKYLSVHSNDWLNSCRLAHSVTKGLA 336

Human   314 YLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVG 378
            ||||||.|||:||.|||||||||||||||:||||||||||||||||||||||||:||||||||||
Frog   337 YLHTELLRGDNYKSAISHRDLNSRNVLVKSDGTCVISDFGLSMRLTGNRLVRPGDEDNAAISEVG 401

Human   379 TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNH 443
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Frog   402 TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEAGNH 466

Human   444 PTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIW 508
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||
Frog   467 PTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIDDCWDQDAEARLTAQCAEERMAELMMIW 531

Human   509 ERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMS 573
            |||||||||:||.|||:|||||||.||||||||||||||||||||||:|:|||||||||||.|:|
Frog   532 ERNKSVSPTINPTSTAVQNERNLSQNRRVPKIGPYPDYSSSSYIEDSVHNTDSIVKNISSETSIS 596

Human   574 STPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDET 638
            |.|||.||||||||||||||||||:|||||||||||||||||||||||||||||||||:.|.|||
Frog   597 SAPLTTGEKNRNSINYERQQAQARLPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEVQYSDET 661

Human   639 NLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTS 703
             :|.   .|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   662 -MHG---VQNIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTS 722

Human   704 SSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKE 768
            |:|.|||||||||:||.|||.||..||||::.||...|:|||||||||||||||||||||||.||
Frog   723 SNLFYPLIKLAVESTGPQDFNQTGIGQACIVQDVHAAQLYPLPKQQNLPKRPTSLPLNTKNSGKE 787

Human   769 PRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGT-VLS 832
            .||||.||||||||.||||||||||:.||||||||||...|:||...|||.....||:|.| |||
Frog   788 SRLKFSSKHKSNLKHVETGVAKMNTVTAAEPHVVTVTTASVSGRTGYVNSQGPAAQYSNTTAVLS 852

Human   833 GQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEG 897
               :|.:.|||||||||||.|||:||||||||||:|||||||||||.||.||||||||||||.|.
Frog   853 ---SNSMAHRAQEMLQNQFRGEDSRLNINSSPDENEPLLRREQQAGQDESVLDRLVDRRERPAEN 914

Human   898 GRTNSNNNNSNPCSEQDVLAQGVPSTA-ADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQ 961
            .|.||||||:   |.|.||.:..|.:| .:....:.||||||||||||.::::|..|.|. |:..
Frog   915 SRVNSNNNNN---SSQCVLQETAPQSALVETRQRQTRRAQRPNSLDLSNSSIMDNCSTQC-ETLS 975

Human   962 DGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAV-HSKSSTAVYLAEGGTA 1025
            |.:|||||||||||||||||||||||||.|.||..||||||||.:... ||||||||||.:||||
Frog   976 DSRSGSGEKIKKRVKTPYSLKRWRPSTWAIPTERQDCEVNNNGGSETFSHSKSSTAVYLIDGGTA 1040

Human  1026 TTMVSKDIGMNCL 1038
            |:.:||:..|:||
Frog  1041 TSTLSKEAKMSCL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMPR2	NP_001195.2	Activin_recp	52..127	CDD:307282	52/75 (69%)
		STKc_BMPR2_AMHR2	207..504	CDD:270956	269/296 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..626		31/32 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770		22/23 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..972		58/100 (58%)
bmpr2	XP_002937761.3	Activin_recp	66..147	CDD:395845	55/80 (69%)
bmpr2	XP_002937761.3	STKc_BMPR2_AMHR2	230..527	CDD:270956	269/296 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	794	1.000	Domainoid score	I1227
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H929
Inparanoid	1	1.050	1606	1.000	Inparanoid score	I1194
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39099
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0006916
OrthoInspector	1	1.000	-	-		oto152505
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5015
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080