DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SLIT3 and sli

DIOPT Version :9

Sequence 1:NP_001258875.2 Gene:SLIT3 / 6586 HGNCID:11087 Length:1530 Species:Homo sapiens
Sequence 2:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster


Alignment Length:1540 Identity:654/1540 - (42%)
Similarity:923/1540 - (59%) Gaps:117/1540 - (7%)


- Green bases have known domain annotations that are detailed below.


Human     3 PGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLD 67
            || .|||....||                  ||..|:|:..:|||...||.:|||.|..:.|||:
  Fly    61 PG-GGVGVITEAR------------------CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLE 106

Human    68 LDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQST 132
            |..||:|.|.:.||..|..||:|.|.|||:..|||.:||||..|||||||.|:|:.:||....|:
  Fly   107 LQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSS 171

Human   133 PKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRIL 197
            ..|.|||:|.|.|..:.|:.|:|...:::||||||.|:|:::.||:.|.:||||||||||::.:.
  Fly   172 ASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLP 236

Human   198 VTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYV 262
            ...|..:.::|.|||..|...|||||:|||.:||....:..:|.|.:|..|:|.||||:..:|:.
  Fly   237 HNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFK 301

Human   263 CP--APHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAG 325
            |.  ..|: |..|.|.: |||.||.|::.|||||.|.|..:|..||:...|:|||||.|..:|..
  Fly   302 CSGLTEHA-PMECGAEN-SCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPK 364

Human   326 AFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANK 390
            :|:.:::|:|||:|.|.||.||.||..|||.||:||||||||.::..|:|.||.||||||||||:
  Fly   365 SFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANE 429

Human   391 INCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN 455
            |:|:|.:.|:||.:|:|||||||.:|:::.|.|..::||:|:|||:|||:|||:|:||||||..|
  Fly   430 ISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKN 494

Human   456 PIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSN 520
            |||||||||.||:|:..:||..::.:||:||..| .|.:.|.||.||..||..|.||||.|||:.
  Fly   495 PIETSGARCESPKRMHRRRIESLREEKFKCSWDE-LRMKLSGECRMDSDCPAMCHCEGTTVDCTG 558

Human   521 QKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQE 585
            :.|..||..:|.:.|:|.|||||:..:.:.|:|.:||:|.|:.|..|::..:...||:||:.:||
  Fly   559 RGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQE 623

Human   586 LMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT 650
            |.|..|:::.:..::|.||..|||                        |:||||:|:.:.||:|.
  Fly   624 LQLGENKIKEISNKMFLGLHQLKT------------------------LNLYDNQISCVMPGSFE 664

Human   651 TLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNE 715
            .|.||:::||.||||||||||||..:||||:.:..|..||..|..::::.|:|:...:|.|....
  Fly   665 HLNSLTSLNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSEN 729

Human   716 ESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE-LSALRHLTL 779
            ...|.....||..|||..||||||...|:.:|||:|.:.:|||||.|.:..:..| :..||.||.
  Fly   730 SEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTR 794

Human   780 IDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFN 844
            :|||||.|::|:||||:|::.|||||:|||:|:|:..||.:||.:||||:||||.||.:|||||.
  Fly   795 LDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFE 859

Human   845 DLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKVLW 909
            ||.||:|:|||:|||:|||.|:|.|:|:|..|.|||||||:.||.|.|:|:|:||:..|.|:   
  Fly   860 DLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCR--- 921

Human   910 FCCPGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHG 974
                |.|..:|:||||||...||:|...|...|...|:|.|...|.||.|...|:.|..|||::.
  Fly   922 ----GRVRNDILAKCNACFEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNN 982

Human   975 GTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDC-EDNDCENNATCVDGINNYVCICPPNYTGELC 1038
            .||.:.:..:  |||.|..|:.|.|||.|.||| .:..|:|||||:||:.:|.|.|.|.::||.|
  Fly   983 ATCTVLEEGR--FSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFC 1045

Human  1039 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN-DDCVAHKCRHGAQCVDTING 1102
            |..|..|.||.|.|.:.|||:.....:||:|..|:.|..| ||| |||..|.|::|..|||.||.
  Fly  1046 DTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHGTNC-TDNIDDCQNHMCQNGGTCVDGIND 1109

Human  1103 YTCTCPQGFSGPFCE--HPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT---CRCPPGFAGPRCE 1162
            |.|.||..::|.:||  :...|:..|||||..:||::|. |.....:.:   |||.||:.|..||
  Fly  1110 YQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHGV-CFQPNAQGSDYLCRCHPGYTGKWCE 1173

Human  1163 KLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSL 1227
            .|.:::||..:|:|||...:.||:||:::..::.:.||||:|.|.:..||:||:.|.:|:.||..
  Fly  1174 YLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVG 1238

Human  1228 SSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTS 1292
            :.|.:|:||.|.|.||::|:|||:.:.:...|.||:|..:|:........:.:.:|::|||:|..
  Fly  1239 NHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVD 1303

Human  1293 TGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKD- 1356
            ....|.:....|.|..|.||:.||.||::|.||.....|. .::|||    ....|..:..|.| 
  Fly  1304 PAQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQRQQ-KITPGC----ALLEGEQQEEEDDE 1363

Human  1357 -SVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTS---YMCKCAEGYGGDLCDNKNDSA 1416
             ..:.|.      |...:|..||||.::|..| :||....:   |.|||..|..|..||....|.
  Fly  1364 QDFMDET------PHIKEEPVDPCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGST 1422

Human  1417 NACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVP 1481
                               ||..:.    :...|::|.      |||.....    .|.:...:.
  Fly  1423 -------------------EPPTVT----AASTCRKEQ------VREYYTEN----DCRSRQPLK 1454

Human  1482 IMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1526
            ..:|.||||.|||.....:|||....|::...:::.::...:|||
  Fly  1455 YAKCVGGCGNQCCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCGC 1499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLIT3NP_001258875.2 LRRNT 33..64 CDD:214470 13/30 (43%)
LRR <62..>220 CDD:227223 74/157 (47%)
LRR 1 62..83 10/20 (50%)
leucine-rich repeat 64..86 CDD:275380 11/21 (52%)
LRR 2 86..107 11/20 (55%)
leucine-rich repeat 87..110 CDD:275380 14/22 (64%)
internalin_A 107..>478 CDD:380193 191/372 (51%)
LRR 3 110..131 11/20 (55%)
leucine-rich repeat 111..134 CDD:275380 12/22 (55%)
LRR 4 134..155 9/20 (45%)
leucine-rich repeat 135..158 CDD:275380 10/22 (45%)
LRR 5 158..179 10/20 (50%)
leucine-rich repeat 159..182 CDD:275380 11/22 (50%)
LRR 6 182..203 11/20 (55%)
leucine-rich repeat 183..206 CDD:275380 11/22 (50%)
leucine-rich repeat 207..308 CDD:275380 46/102 (45%)
LRR 7 308..329 9/20 (45%)
leucine-rich repeat 309..332 CDD:275380 9/22 (41%)
LRR_8 311..367 CDD:338972 32/55 (58%)
LRR 8 332..353 12/20 (60%)
leucine-rich repeat 333..356 CDD:275380 14/22 (64%)
LRR 9 356..377 12/20 (60%)
leucine-rich repeat 357..377 CDD:275380 12/19 (63%)
LRR 10 380..401 14/20 (70%)
leucine-rich repeat 381..404 CDD:275380 15/22 (68%)
LRR 11 404..425 11/20 (55%)
leucine-rich repeat 405..428 CDD:275380 11/22 (50%)
LRRNT 505..535 CDD:214470 14/29 (48%)
LRR 12 533..554 8/20 (40%)
LRR_8 534..593 CDD:338972 24/58 (41%)
leucine-rich repeat 534..558 CDD:275380 10/23 (43%)
LRR 13 558..579 6/20 (30%)
leucine-rich repeat 559..582 CDD:275380 8/22 (36%)
LRR_8 582..641 CDD:338972 16/58 (28%)
LRR 14 582..603 6/20 (30%)
leucine-rich repeat 583..606 CDD:275380 8/22 (36%)
LRR 15 606..627 3/20 (15%)
leucine-rich repeat 607..630 CDD:275380 3/22 (14%)
LRR 16 630..651 9/20 (45%)
leucine-rich repeat 631..654 CDD:275380 10/22 (45%)
PCC 636..>714 CDD:188093 37/77 (48%)
leucine-rich repeat 655..745 CDD:275380 40/89 (45%)
LRRNT 725..756 CDD:214470 16/30 (53%)
LRR <743..>869 CDD:227223 73/126 (58%)
leucine-rich repeat 746..776 CDD:275380 12/30 (40%)
LRR 17 753..775 7/22 (32%)
LRR_8 776..835 CDD:338972 36/58 (62%)
LRR 18 776..797 13/20 (65%)
leucine-rich repeat 777..800 CDD:275380 14/22 (64%)
LRR 19 800..821 12/20 (60%)
leucine-rich repeat 801..824 CDD:275380 14/22 (64%)
LRR 20 824..845 15/20 (75%)
leucine-rich repeat 825..846 CDD:275380 15/20 (75%)
PCC 830..>912 CDD:188093 48/81 (59%)
EGF_CA 963..1001 CDD:238011 14/37 (38%)
EGF_CA 1005..1038 CDD:238011 17/33 (52%)
EGF_CA 1042..1079 CDD:238011 14/36 (39%)
EGF_CA 1081..1117 CDD:238011 18/36 (50%)
EGF 1130..1160 CDD:333761 11/32 (34%)
LamG 1188..1321 CDD:214598 47/132 (36%)
EGF 1379..1407 CDD:333761 11/31 (35%)
GHB_like <1473..1528 CDD:389804 16/54 (30%)
sliNP_001261017.1 LRRNT 73..103 CDD:214470 13/29 (45%)
leucine-rich repeat 83..104 CDD:275380 9/20 (45%)
LRR_8 102..160 CDD:290566 33/57 (58%)
leucine-rich repeat 105..125 CDD:275380 9/19 (47%)
LRR_RI <119..259 CDD:238064 66/139 (47%)
leucine-rich repeat 126..149 CDD:275380 14/22 (64%)
LRR_8 149..208 CDD:290566 28/58 (48%)
leucine-rich repeat 150..173 CDD:275380 12/22 (55%)
leucine-rich repeat 174..197 CDD:275380 10/22 (45%)
LRR_8 197..256 CDD:290566 27/58 (47%)
leucine-rich repeat 198..221 CDD:275380 11/22 (50%)
leucine-rich repeat 222..245 CDD:275380 11/22 (50%)
leucine-rich repeat 246..371 CDD:275380 55/126 (44%)
LRRCT 254..303 CDD:214507 21/48 (44%)
LRRNT 319..350 CDD:214470 15/30 (50%)
LRR_8 349..406 CDD:290566 32/56 (57%)
LRR_4 371..411 CDD:289563 25/39 (64%)
leucine-rich repeat 372..395 CDD:275380 14/22 (64%)
leucine-rich repeat 396..415 CDD:275380 11/18 (61%)
leucine-rich repeat 420..443 CDD:275380 15/22 (68%)
leucine-rich repeat 444..465 CDD:275380 11/20 (55%)
leucine-rich repeat 468..480 CDD:275378 8/11 (73%)
LRRCT 476..525 CDD:214507 30/48 (63%)
leucine-rich repeat 484..545 CDD:275380 34/61 (56%)
LRRNT 542..574 CDD:214470 14/31 (45%)
leucine-rich repeat 552..570 CDD:275380 7/17 (41%)
leucine-rich repeat 572..596 CDD:275380 10/23 (43%)
LRR_RI <574..>678 CDD:238064 44/127 (35%)
LRR_8 595..655 CDD:290566 25/83 (30%)
leucine-rich repeat 597..620 CDD:275380 8/22 (36%)
leucine-rich repeat 621..644 CDD:275380 8/22 (36%)
leucine-rich repeat 645..668 CDD:275380 13/46 (28%)
leucine-rich repeat 669..756 CDD:275380 39/86 (45%)
LRRCT 677..726 CDD:214507 22/48 (46%)
LRRNT 739..770 CDD:214470 16/30 (53%)
leucine-rich repeat 757..791 CDD:275380 13/33 (39%)
LRR_4 770..807 CDD:289563 18/36 (50%)
LRR_8 790..850 CDD:290566 37/59 (63%)
LRR_4 791..830 CDD:289563 24/38 (63%)
leucine-rich repeat 792..815 CDD:275380 14/22 (64%)
LRR_4 814..863 CDD:289563 31/48 (65%)
leucine-rich repeat 816..839 CDD:275380 14/22 (64%)
leucine-rich repeat 840..861 CDD:275380 15/20 (75%)
LRRCT 872..920 CDD:214507 28/47 (60%)
EGF 935..966 CDD:278437 11/30 (37%)
EGF_CA 971..1007 CDD:238011 14/37 (38%)
EGF_CA 1009..1045 CDD:238011 18/35 (51%)
EGF_CA 1055..1086 CDD:238011 12/31 (39%)
EGF_CA 1088..1124 CDD:238011 17/35 (49%)
Laminin_G_1 1204..1335 CDD:278483 47/130 (36%)
CT 1435..1504 CDD:214482 20/75 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5521
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1361 1.000 Inparanoid score I132
Isobase 1 0.950 - 0 Normalized mean entropy S3289
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm40542
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3290
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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