DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SLIT1 and sli

DIOPT Version :9

Sequence 1:NP_003052.2 Gene:SLIT1 / 6585 HGNCID:11085 Length:1534 Species:Homo sapiens
Sequence 2:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster


Alignment Length:1561 Identity:666/1561 - (42%)
Similarity:935/1561 - (59%) Gaps:139/1561 - (8%)


- Green bases have known domain annotations that are detailed below.


Human     6 GWGSSAGPVRPELWLLLWAAAWRLGA---------------SACPALCTCTGTTVDCHGTGLQAI 55
            |:||||            .::..||:               :.||.:|:|||..|||...||.::
  Fly    42 GFGSSA------------VSSGGLGSVGIHIPGGGVGVITEARCPRVCSCTGLNVDCSHRGLTSV 94

Human    56 PKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
            |:.|..:.|||||.|||:|.|::.||..|.:||:|||.:|||..:||.:|.|:..|||||||.|:
  Fly    95 PRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNR 159

Human   121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEV 185
            |..:||....::.:|.|||:|.|.|..:.|:.|:||..|::||||.|||:|::|.||:.|..||:
  Fly   160 LKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEI 224

Human   186 LTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRG 250
            |||||||:|::|.:.|..:.:||..||..|...|||||:|||::||....:..:|:|..|:.|:|
  Fly   225 LTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKG 289

Human   251 LNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIR 315
            .|||::...||.|||..|  ..|....:..|||..|.|::||||||.|.||::|..||:..||:|
  Fly   290 QNVADLHDQEFKCSGLTE--HAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELR 352

Human   316 LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGL 380
            ||.|.|..:||.:||.:|:|||||||||.|:.||.||..||:.|.:||||||||.|||.|||.||
  Fly   353 LEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGL 417

Human   381 YTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
            .:|||||||||:|:|||.|||:||.:|||||||||.|||||.|||.::::|:|:|||:|||||||
  Fly   418 GSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDC 482

Human   446 NLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSD 510
            ||:||||:|..||||||||||.||:|:..:||..::.:||:||..|...       :|:.||..|
  Fly   483 NLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSWDELRM-------KLSGECRMD 540

Human   511 VVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNN 575
            ..||..|.||...|:|:...|.:||..||..|.||.||:||:..:.:.|:|.:|.||.|:.|..|
  Fly   541 SDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRN 605

Human   576 KVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVR 640
            :::.||..|||||:.:.||.|..|:::.|.:.||.||..|:|                       
  Fly   606 QLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKT----------------------- 647

Human   641 LLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLR 705
             |:||||||:.|.||:|:.|.||::|||.:|||||||.|||...||||:.:..|..||..|..:|
  Fly   648 -LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVR 711

Human   706 QIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDG 770
            .:.::|:...:|:|.....| |||....||..|.|..||||||...|:.:|:|||...:||||:.
  Fly   712 DVQIKDLPHSEFKCSSENSE-GCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLES 775

Human   771 NQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSL 834
            |:...:. .::...:.|..:|||||:|:.|||.:|.|:::|:|||:|||.|||:...|..||.:|
  Fly   776 NEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNL 840

Human   835 RLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDM 899
            |:||||||.||.|.||.|.|:.||:|:|:|:|||||||.|:|.|.|:|..|.||||||||.|:.|
  Fly   841 RVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQM 905

Human   900 EGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVS 964
            :.||:|:||:..|.|:|.....:.|||:.|...|||||..|...|...|:|.|..||.|:.||..
  Fly   906 KDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFM 970

Human   965 LDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCV-DHACANGGVCVDGVGNYT 1028
            :|:|...||.|..||...  |:..|:|.|..|:.|..|..|.|||: :..|.|...|:|||.:|.
  Fly   971 IDACYGNPCRNNATCTVL--EEGRFSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYK 1033

Human  1029 CQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQ 1093
            |:|...:.|:.|:..:..|||:.|||.:.|:|:.......|:|..|:.|.||::|.|||::|.||
  Fly  1034 CECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHMCQ 1098

Human  1094 NGAQCMDEVNSYSCLCAEGYSGQLCE----IPPHLPAPKSPCEGTECQNGANCVD---QGNRPVC 1151
            ||..|:|.:|.|.|.|.:.|:|:.||    |....| ..|||:..||::|. |..   ||:..:|
  Fly  1099 NGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYP-QTSPCQNHECKHGV-CFQPNAQGSDYLC 1161

Human  1152 QCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVEL 1216
            :|.||:.|..||.|.|::||..:::::...|:..|.||:|:..|:||.||||:|:|.:.|:||||
  Fly  1162 RCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGILMYDGQDAHLAVEL 1226

Human  1217 YQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNS 1281
            :.|.:|||||.|::|.|.:||.|.:.||::|.|||:|..:...|.:|.|...::.|.|.:..|..
  Fly  1227 FNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKL 1291

Human  1282 EAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLY 1346
            ..|:::||:|||....|::.|||.|.|.|.||::.::||::|.||...|.:..:.|||.      
  Fly  1292 TTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQRQQKITPGCA------ 1350

Human  1347 CLHGICQP---------NATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDAL--SY 1399
            .|.|..|.         :.||    |.:        ::|.| ||..:||..| :|||....  .|
  Fly  1351 LLEGEQQEEEDDEQDFMDETP----HIK--------EEPVD-PCLENKCRRGSRCVPNSNARDGY 1402

Human  1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPV 1464
            .|:|:.|..|..|:|.....||                        |..:.     .|.||.:.|
  Fly  1403 QCKCKHGQRGRYCDQGEGSTEP------------------------PTVTA-----ASTCRKEQV 1438

Human  1465 RDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCG 1529
            |:::....    |::.:||.:.:|.|.| |..||....::|||....||:...:.:.::...|||
  Fly  1439 REYYTEND----CRSRQPLKYAKCVGGC-GNQCCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCG 1498

Human  1530 C 1530
            |
  Fly  1499 C 1499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLIT1NP_003052.2 LRRNT 33..64 CDD:214470 13/30 (43%)
leucine-rich repeat 43..62 CDD:275380 7/18 (39%)
LRR_8 61..121 CDD:290566 33/59 (56%)
LRR 1 62..83 12/20 (60%)
leucine-rich repeat 63..86 CDD:275380 13/22 (59%)
LRR_4 64..101 CDD:289563 21/36 (58%)
LRR 2 86..107 11/20 (55%)
LRR_RI <87..220 CDD:238064 64/132 (48%)
leucine-rich repeat 87..110 CDD:275380 12/22 (55%)
LRR_8 109..169 CDD:290566 28/59 (47%)
LRR 3 110..131 11/20 (55%)
leucine-rich repeat 111..134 CDD:275380 11/22 (50%)
LRR 4 134..155 9/20 (45%)
leucine-rich repeat 135..158 CDD:275380 11/22 (50%)
LRR 5 158..179 12/20 (60%)
LRR_8 159..217 CDD:290566 30/57 (53%)
leucine-rich repeat 159..182 CDD:275380 13/22 (59%)
LRR 6 182..203 12/20 (60%)
leucine-rich repeat 183..206 CDD:275380 12/22 (55%)
leucine-rich repeat 207..334 CDD:275380 58/126 (46%)
TPKR_C2 219..264 CDD:301599 20/44 (45%)
LRRNT 282..313 CDD:214470 16/30 (53%)
LRR 7 310..331 10/20 (50%)
LRR_8 312..369 CDD:290566 35/56 (63%)
LRR_4 334..373 CDD:289563 26/38 (68%)
LRR 8 334..355 14/20 (70%)
leucine-rich repeat 335..358 CDD:275380 16/22 (73%)
LRR 9 358..379 15/20 (75%)
leucine-rich repeat 359..379 CDD:275380 15/19 (79%)
LRR 10 382..403 16/20 (80%)
leucine-rich repeat 383..406 CDD:275380 18/22 (82%)
LRR_8 389..441 CDD:290566 35/51 (69%)
LRR 11 406..427 17/20 (85%)
leucine-rich repeat 407..428 CDD:275380 17/20 (85%)
leucine-rich repeat 431..528 CDD:275380 50/96 (52%)
TPKR_C2 439..>469 CDD:301599 24/29 (83%)
LRRNT 513..542 CDD:214470 12/28 (43%)
leucine-rich repeat 529..566 CDD:275380 15/36 (42%)
LRR 12 541..562 8/20 (40%)
LRR_RI <544..627 CDD:238064 32/82 (39%)
LRR_8 544..601 CDD:290566 25/56 (45%)
LRR 13 566..587 9/20 (45%)
leucine-rich repeat 567..590 CDD:275380 11/22 (50%)
LRR_8 590..649 CDD:290566 16/58 (28%)
LRR 14 590..611 7/20 (35%)
leucine-rich repeat 591..614 CDD:275380 9/22 (41%)
LRR 15 614..635 2/20 (10%)
LRR_4 615..654 CDD:289563 10/38 (26%)
leucine-rich repeat 615..638 CDD:275380 2/22 (9%)
LRR 16 638..659 11/20 (55%)
leucine-rich repeat 639..660 CDD:275380 11/20 (55%)
leucine-rich repeat 663..762 CDD:275380 45/98 (46%)
LRRCT 671..719 CDD:214507 21/47 (45%)
LRRNT 733..765 CDD:214470 15/31 (48%)
LRR_8 761..820 CDD:290566 24/59 (41%)
LRR 17 762..783 5/21 (24%)
leucine-rich repeat 763..785 CDD:275380 5/22 (23%)
LRR 18 785..806 11/20 (55%)
LRR_4 786..827 CDD:289563 22/40 (55%)
leucine-rich repeat 786..809 CDD:275380 12/22 (55%)
LRR 19 809..830 11/20 (55%)
leucine-rich repeat 810..830 CDD:275380 11/19 (58%)
LRR 20 833..854 14/20 (70%)
leucine-rich repeat 834..857 CDD:275380 15/22 (68%)
LRRCT 866..915 CDD:214507 29/48 (60%)
EGF_CA 927..962 CDD:238011 14/34 (41%)
EGF_CA 966..1002 CDD:238011 13/35 (37%)
EGF_CA 1005..1041 CDD:238011 14/36 (39%)
EGF_CA 1044..1080 CDD:238011 12/35 (34%)
EGF_CA 1085..1119 CDD:238011 16/33 (48%)
EGF_CA <1136..1163 CDD:238011 10/29 (34%)
LamG 1189..1322 CDD:214598 58/132 (44%)
sliNP_001261017.1 LRRNT 73..103 CDD:214470 13/29 (45%)
leucine-rich repeat 83..104 CDD:275380 7/20 (35%)
LRR_8 102..160 CDD:290566 33/57 (58%)
leucine-rich repeat 105..125 CDD:275380 11/19 (58%)
LRR_RI <119..259 CDD:238064 67/139 (48%)
leucine-rich repeat 126..149 CDD:275380 12/22 (55%)
LRR_8 149..208 CDD:290566 28/58 (48%)
leucine-rich repeat 150..173 CDD:275380 11/22 (50%)
leucine-rich repeat 174..197 CDD:275380 11/22 (50%)
LRR_8 197..256 CDD:290566 30/58 (52%)
leucine-rich repeat 198..221 CDD:275380 13/22 (59%)
leucine-rich repeat 222..245 CDD:275380 12/22 (55%)
leucine-rich repeat 246..371 CDD:275380 58/126 (46%)
LRRCT 254..303 CDD:214507 21/48 (44%)
LRRNT 319..350 CDD:214470 16/30 (53%)
LRR_8 349..406 CDD:290566 35/56 (63%)
LRR_4 371..411 CDD:289563 27/39 (69%)
leucine-rich repeat 372..395 CDD:275380 16/22 (73%)
leucine-rich repeat 396..415 CDD:275380 14/18 (78%)
leucine-rich repeat 420..443 CDD:275380 18/22 (82%)
leucine-rich repeat 444..465 CDD:275380 17/20 (85%)
leucine-rich repeat 468..480 CDD:275378 8/11 (73%)
LRRCT 476..525 CDD:214507 31/48 (65%)
leucine-rich repeat 484..545 CDD:275380 31/67 (46%)
LRRNT 542..574 CDD:214470 13/31 (42%)
leucine-rich repeat 552..570 CDD:275380 6/17 (35%)
leucine-rich repeat 572..596 CDD:275380 10/23 (43%)
LRR_RI <574..>678 CDD:238064 49/127 (39%)
LRR_8 595..655 CDD:290566 28/83 (34%)
leucine-rich repeat 597..620 CDD:275380 11/22 (50%)
leucine-rich repeat 621..644 CDD:275380 9/22 (41%)
leucine-rich repeat 645..668 CDD:275380 14/46 (30%)
leucine-rich repeat 669..756 CDD:275380 40/87 (46%)
LRRCT 677..726 CDD:214507 21/48 (44%)
LRRNT 739..770 CDD:214470 15/30 (50%)
leucine-rich repeat 757..791 CDD:275380 10/33 (30%)
LRR_4 770..807 CDD:289563 13/36 (36%)
LRR_8 790..850 CDD:290566 33/59 (56%)
LRR_4 791..830 CDD:289563 22/38 (58%)
leucine-rich repeat 792..815 CDD:275380 12/22 (55%)
LRR_4 814..863 CDD:289563 28/48 (58%)
leucine-rich repeat 816..839 CDD:275380 13/22 (59%)
leucine-rich repeat 840..861 CDD:275380 14/20 (70%)
LRRCT 872..920 CDD:214507 29/47 (62%)
EGF 935..966 CDD:278437 14/30 (47%)
EGF_CA 971..1007 CDD:238011 13/37 (35%)
EGF_CA 1009..1045 CDD:238011 14/35 (40%)
EGF_CA 1055..1086 CDD:238011 10/30 (33%)
EGF_CA 1088..1124 CDD:238011 17/35 (49%)
Laminin_G_1 1204..1335 CDD:278483 57/130 (44%)
CT 1435..1504 CDD:214482 20/70 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5521
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1361 1.000 Inparanoid score I132
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm40542
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3290
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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