DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLIT1 and slt-1

DIOPT Version :9

Sequence 1:NP_003052.2 Gene:SLIT1 / 6585 HGNCID:11085 Length:1534 Species:Homo sapiens
Sequence 2:NP_510437.2 Gene:slt-1 / 181562 WormBaseID:WBGene00004854 Length:1410 Species:Caenorhabditis elegans


Alignment Length:1526 Identity:568/1526 - (37%)
Similarity:793/1526 - (51%) Gaps:165/1526 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    31 ASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMEN 95
            ::.|||.|.|...||.|.|..|..:|:|||.:|.||:|..|.||:|..|||:.|..|:.||||:|
 Worm    14 SATCPAECVCVDRTVSCVGQQLTEVPQNIPNDTIRLDLQDNEITKIGPNDFSSLMNLKALQLMDN 78

Human    96 QIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLK 160
            ||..:...:|..:..|::|||:||::..||:.:||||..|:.||||||.|..:.....:|...|:
 Worm    79 QIVTIHNQSFSSLVFLQKLRLSRNRIRHLPDNVFQNNLKLTHLDLSENDITVVSDAQLQGPEFLE 143

Human   161 NLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAW 225
            .|.||||.|.|:|.....:...|||||||.|.:||....|   ..:.|...|.:|...|||.|.|
 Worm   144 VLNLDKNHIFCLENNVISSWVSLEVLTLNGNRLTTFEEPS---NARFRQLDLFNNPWNCDCRLRW 205

Human   226 LSQWLR----QRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMC 286
            :.:||.    |..|:     |:.|.:|:|.::..:|....:|||..:.....||. ::..||..|
 Worm   206 MRKWLEKAEGQNKTV-----CATPLNLQGSSIEILQDKFMTCSGNRKRRYKKTCE-TAEICPLPC 264

Human   287 TCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPD 351
            ||:...||||..|||.:|.|||.:.||||||.|.|.|||..:|...:.|.|:|||.|.|.||.|.
 Worm   265 TCTGTTVDCRDSGLTYVPTNLPPSTTEIRLEQNQISSIPSHSFKNLKNLTRLDLSKNIITEIQPK 329

Human   352 AFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNK 416
            ||.||.:|::||||||.||||....|.||.:|||||||||::.|||...|..:..||:||||||.
 Worm   330 AFLGLHNLHTLVLYGNNITDLKSDTFEGLGSLQLLLLNANQLTCIRRGTFDHVPKLSMLSLYDND 394

Human   417 IQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIK 481
            |:|:::.||.:|.::.|||||:||.||||||:|||.......||||||||..|:||..|:...:.
 Worm   395 IKSISEVTFQNLTSLSTLHLAKNPLICDCNLQWLAQINLQKNIETSGARCEQPKRLRKKKFATLP 459

Human   482 SKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELR 546
            ..||:|...|. |:....|     .|..|.:||.:|.|....|:|:...|..||..||:...:|.
 Worm   460 PNKFKCKGSES-FVSMYAD-----SCFIDSICPTQCDCYGTTVDCNKRGLNTIPTSIPRFATQLL 518

Human   547 LNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRG 611
            |:.|.||.::.......|.:|:.::||||.::.|.|.:||..:.:.||.|..|:|....|.:...
 Worm   519 LSGNNISTVDLNSNIHVLENLEVLDLSNNHITFINDKSFEKLSKLRELRLNDNKLHHFSSMVLDE 583

Human   612 LDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCN 676
            ...|..|.|..|.|.|..             |::.|:.|.:           ..:.::.|...|:
 Worm   584 QSNLEILDLSGNNIQCFS-------------SIFFNKATRI-----------REIKVIGNDLLCD 624

Human   677 CQLAWLGGWLRKRKIVTGN-PRCQNPDFLRQIPLQD--------VAFPDFRCEEGQEEGGCLPRP 732
            |::..|..|||.....:.: |.||      |....|        .|||:..|.:...        
 Worm   625 CRILPLMSWLRSNSSHSIDIPPCQ------QFQYSDNESDKQRCAAFPEETCSDDSN-------- 675

Human   733 QCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG-QLSTFKYLQLVDLSNNKI 796
            .||.:|:|||.|||||||:|.:.|..||.:.||||||.|....:|. .|:....|..:|||:|::
 Worm   676 LCPPKCSCLDRVVRCSNKNLTSFPSRIPFDTTELYLDANYINEIPAHDLNRLYSLTKLDLSHNRL 740

Human   797 SSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL 861
            .||.|::|:|:::|:|||:|||.|:|:.||||.||.:||:|||||||||.|.:..|:::||::|:
 Worm   741 ISLENNTFSNLTRLSTLIISYNKLRCLQPLAFNGLNALRILSLHGNDISFLPQSAFSNLTSITHI 805

Human   862 AIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKC 926
            |:|:|.|||||::.|.|.|:|:.:.|.|||||..|..:..:||||....:|.|.......:..||
 Worm   806 AVGSNSLYCDCNMAWFSKWIKSKFIEAGIARCEYPNTVSNQLLLTAQPYQFTCDSKVPTKLATKC 870

Human   927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCH-AQEGEDAPFT 990
            ||||:|||:|...|.......|.|.|..|:.|..||..:|:|...||.|..||. ||.|.   |.
 Worm   871 DLCLNSPCKNNAICETTSSRKYTCNCTPGFYGVHCENQIDACYGSPCLNNATCKVAQAGR---FN 932

Human   991 CSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQ 1055
            |.|..||||..|..|.||||:..|.|||.|||.:.:|.|.||::||||.||..::.|:..||||:
 Worm   933 CYCNKGFEGDYCEKNIDDCVNSKCENGGKCVDLINSYRCDCPMEYEGKHCEDKLEYCTKKLNPCE 997

Human  1056 HEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
            :..:|:.......|.|.||:.|:||..|.|||::..||||..|:|.:.||.|||..||:||.|||
 Worm   998 NNGKCIPINGSYSCMCSPGFTGNNCETNIDDCKNVECQNGGSCVDGILSYDCLCRPGYAGQYCEI 1062

Human  1121 PPHLP---APKSPCEGTECQNGANCVDQGNRP--VCQCLPGFGGPECEKLLSVNFVDRDTYLQFT 1180
            ||.:.   .....|:.:.|..| .||...|..  .|:|..||.||.|::.:||.|.:...||...
 Worm  1063 PPMMDMEYQKTDACQQSACGQG-ECVASQNSSDFTCKCHEGFSGPSCDRQMSVGFKNPGAYLALD 1126

Human  1181 DLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQ 1245
            .|.:  ...||:.:.|....|||||.||:..::.|||.|.|::.|..|::|:|.:||:..:|||.
 Worm  1127 PLAS--DGTITMTLRTTSKIGILLYYGDDHFVSAELYDGRVKLVYYIGNFPASHMYSSVKVNDGL 1189

Human  1246 FHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTL--NSEAPLYVGGMPVDVNSAAFRLWQILNGT 1308
            .|.:.:...::...|.||......::|.||...|  ..:..||:||:|::.:..|.|.:.:.|..
 Worm  1190 PHRISIRTSERKCFLQIDKNPVQIVENSGKSDQLITKGKEMLYIGGLPIEKSQDAKRRFHVKNSE 1254

Human  1309 GFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHC 1373
            ...|||.::.||.              ||                        .:.:.....::.
 Worm  1255 SLKGCISSITINE--------------VP------------------------INLQQALENVNT 1281

Human  1374 DQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHC--QASG 1436
            :|                        ||              .|....|.|:.|.:|.|  .|..
 Worm  1282 EQ------------------------SC--------------SATVNFCAGIDCGNGKCTNNALS 1308

Human  1437 TKGAHCVCDPGFSGELC-EQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPG-QGCCQ 1499
            .||..|.||..||||.| |:..:|.....|..|....    |::...:...||.|.|.| |.||.
 Worm  1309 PKGYMCQCDSHFSGEHCDEKRIKCDKQKFRRHHIENE----CRSVDRIKIAECNGYCGGEQNCCT 1369

Human  1500 GLRLKRRKFTFECSDGTSFAEEVEKPTKCGC 1530
            .::.|:||....|.:||:....|....:|.|
 Worm  1370 AVKKKQRKVKMICKNGTTKISTVHIIRQCQC 1400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLIT1NP_003052.2 LRRNT 33..64 CDD:214470 14/30 (47%)
leucine-rich repeat 43..62 CDD:275380 9/18 (50%)
LRR_8 61..121 CDD:290566 27/59 (46%)
LRR 1 62..83 11/20 (55%)
leucine-rich repeat 63..86 CDD:275380 12/22 (55%)
LRR_4 64..101 CDD:289563 19/36 (53%)
LRR 2 86..107 9/20 (45%)
LRR_RI <87..220 CDD:238064 53/132 (40%)
leucine-rich repeat 87..110 CDD:275380 9/22 (41%)
LRR_8 109..169 CDD:290566 27/59 (46%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 12/22 (55%)
LRR 4 134..155 8/20 (40%)
leucine-rich repeat 135..158 CDD:275380 9/22 (41%)
LRR 5 158..179 9/20 (45%)
LRR_8 159..217 CDD:290566 23/57 (40%)
leucine-rich repeat 159..182 CDD:275380 9/22 (41%)
LRR 6 182..203 11/20 (55%)
leucine-rich repeat 183..206 CDD:275380 11/22 (50%)
leucine-rich repeat 207..334 CDD:275380 50/130 (38%)
TPKR_C2 219..264 CDD:301599 14/48 (29%)
LRRNT 282..313 CDD:214470 16/30 (53%)
LRR 7 310..331 12/20 (60%)
LRR_8 312..369 CDD:290566 33/56 (59%)
LRR_4 334..373 CDD:289563 24/38 (63%)
LRR 8 334..355 12/20 (60%)
leucine-rich repeat 335..358 CDD:275380 14/22 (64%)
LRR 9 358..379 12/20 (60%)
leucine-rich repeat 359..379 CDD:275380 12/19 (63%)
LRR 10 382..403 13/20 (65%)
leucine-rich repeat 383..406 CDD:275380 13/22 (59%)
LRR_8 389..441 CDD:290566 26/51 (51%)
LRR 11 406..427 12/20 (60%)
leucine-rich repeat 407..428 CDD:275380 12/20 (60%)
leucine-rich repeat 431..528 CDD:275380 42/96 (44%)
TPKR_C2 439..>469 CDD:301599 19/29 (66%)
LRRNT 513..542 CDD:214470 11/28 (39%)
leucine-rich repeat 529..566 CDD:275380 11/36 (31%)
LRR 12 541..562 5/20 (25%)
LRR_RI <544..627 CDD:238064 26/82 (32%)
LRR_8 544..601 CDD:290566 19/56 (34%)
LRR 13 566..587 8/20 (40%)
leucine-rich repeat 567..590 CDD:275380 9/22 (41%)
LRR_8 590..649 CDD:290566 14/58 (24%)
LRR 14 590..611 6/20 (30%)
leucine-rich repeat 591..614 CDD:275380 6/22 (27%)
LRR 15 614..635 6/20 (30%)
LRR_4 615..654 CDD:289563 9/38 (24%)
leucine-rich repeat 615..638 CDD:275380 6/22 (27%)
LRR 16 638..659 3/20 (15%)
leucine-rich repeat 639..660 CDD:275380 3/20 (15%)
leucine-rich repeat 663..762 CDD:275380 33/107 (31%)
LRRCT 671..719 CDD:214507 15/56 (27%)
LRRNT 733..765 CDD:214470 17/31 (55%)
LRR_8 761..820 CDD:290566 26/59 (44%)
LRR 17 762..783 9/21 (43%)
leucine-rich repeat 763..785 CDD:275380 9/22 (41%)
LRR 18 785..806 9/20 (45%)
LRR_4 786..827 CDD:289563 20/40 (50%)
leucine-rich repeat 786..809 CDD:275380 10/22 (45%)
LRR 19 809..830 13/20 (65%)
leucine-rich repeat 810..830 CDD:275380 13/19 (68%)
LRR 20 833..854 13/20 (65%)
leucine-rich repeat 834..857 CDD:275380 13/22 (59%)
LRRCT 866..915 CDD:214507 22/48 (46%)
EGF_CA 927..962 CDD:238011 14/34 (41%)
EGF_CA 966..1002 CDD:238011 17/36 (47%)
EGF_CA 1005..1041 CDD:238011 20/35 (57%)
EGF_CA 1044..1080 CDD:238011 11/35 (31%)
EGF_CA 1085..1119 CDD:238011 18/33 (55%)
EGF_CA <1136..1163 CDD:238011 11/28 (39%)
LamG 1189..1322 CDD:214598 45/134 (34%)
slt-1NP_510437.2 LRRNT 17..47 CDD:214470 14/29 (48%)
leucine-rich repeat 26..45 CDD:275380 9/18 (50%)
LRR_RI <48..195 CDD:238064 63/149 (42%)
LRR_8 48..104 CDD:290566 26/55 (47%)
leucine-rich repeat 48..69 CDD:275380 11/20 (55%)
leucine-rich repeat 70..93 CDD:275380 9/22 (41%)
LRR_8 94..152 CDD:290566 27/57 (47%)
leucine-rich repeat 94..117 CDD:275380 12/22 (55%)
leucine-rich repeat 118..165 CDD:275380 18/46 (39%)
LRR_8 142..196 CDD:290566 22/56 (39%)
leucine-rich repeat 142..163 CDD:275380 9/20 (45%)
leucine-rich repeat 166..284 CDD:275380 46/126 (37%)
LRRCT 195..243 CDD:214507 15/52 (29%)
LRRNT 259..291 CDD:214470 16/31 (52%)
leucine-rich repeat 285..312 CDD:275380 14/26 (54%)
LRR_8 287..347 CDD:290566 33/59 (56%)
LRR_4 311..352 CDD:289563 25/40 (63%)
leucine-rich repeat 313..336 CDD:275380 14/22 (64%)
LRR_8 336..419 CDD:290566 46/82 (56%)
leucine-rich repeat 337..384 CDD:275380 27/46 (59%)
leucine-rich repeat 385..408 CDD:275380 13/22 (59%)
LRRCT 417..466 CDD:214507 25/48 (52%)
LRRNT 484..512 CDD:214470 10/27 (37%)
leucine-rich repeat 494..516 CDD:275380 7/21 (33%)
LRR_RI <514..635 CDD:238064 35/144 (24%)
leucine-rich repeat 517..538 CDD:275380 6/20 (30%)
LRR_8 538..597 CDD:290566 19/58 (33%)
leucine-rich repeat 539..562 CDD:275380 9/22 (41%)
leucine-rich repeat 563..586 CDD:275380 6/22 (27%)
leucine-rich repeat 587..610 CDD:275380 8/35 (23%)
leucine-rich repeat 611..675 CDD:275380 16/80 (20%)
leucine-rich repeat 676..729 CDD:275380 26/52 (50%)
LRRNT 677..708 CDD:214470 17/30 (57%)
LRR_8 729..788 CDD:290566 33/58 (57%)
LRR_4 729..771 CDD:289563 20/41 (49%)
leucine-rich repeat 730..753 CDD:275380 10/22 (45%)
leucine-rich repeat 754..777 CDD:275380 15/22 (68%)
leucine-rich repeat 778..799 CDD:275380 13/20 (65%)
EGF_CA 909..945 CDD:238011 17/38 (45%)
EGF_CA 947..983 CDD:238011 20/35 (57%)
EGF_CA <994..1023 CDD:238011 10/28 (36%)
EGF_CA 1025..1061 CDD:238011 19/35 (54%)
LamG 1133..1268 CDD:214598 45/148 (30%)
CT 1334..1405 CDD:214482 20/71 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 83 1.000 Domainoid score I5834
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 998 1.000 Inparanoid score I151
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm15963
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3290
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.870

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