DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A5 and CG6356

DIOPT Version :9

Sequence 1:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	157/567 - (27%)
Similarity:	253/567 - (44%)	Gaps:	72/567 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    11 LGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHR-CRVPDA--ANLSSAWRNHTVPLRLR 72
            :|..|.|...||||.....|.|||...|...|...|:.: |.:|:.  .|.:.|.:...|...|.
  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAKGLD 95

Human    73 DGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAY 137
            .|...........||.::..:||..       .|.|.|        .|....:|..|..|...|:
  Fly    96 SGGCTVWDWNYGHLAKMSYEAALNY-------TGHLTQ--------ISPPAEVSCRVKGQHEFAH 145

Human   138 NAMKNRMGKKPALCLPAQWNLVCE---DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKN---- 195
                      |.....|.|:|.|:   ....|.::|||   |...|||..|.|:|:||||:
  Fly   146 ----------PETTFVADWDLTCDRSIQRTSAQVSISL---GKFCGSFSFGILADKFGRKSSFTL 197

Human   196 -VLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR----IIFS 255
             ..|..:|     ||...||..:.:|:.....:|......:..||.:..|.:....|    |.||
  Fly   198 GAAFFIVG-----SFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFS 257

Human   256 TLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEA-EV 319
            .     .|..|.::|.:..|.|:.||.|.:|||:|.:|.:...:.:.|||||||:..|::.. ::
  Fly   258 A-----SYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKI 317

Human   320 IIRKAAKAN---GIVVPSTI------FDPSELQDLSSKKQQS--HNILDLLRTWNIRMVTIMSIM 373
            :.|:.:...   .:..||.:      .:|.|......|.:..  .:|::|.....:|.:...|..
  Fly   318 LFRQPSHYQIQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYF 382

Human   374 LWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFL---GG 435
            ::...|:.|:..:|:..||....::....:.:|::|:|::..::|::..||   .|.:||   .|
  Fly   383 MFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRR---LTTMFLFLWTG 444

Human   436 SVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 500
            ..||.:..||...........|:|:||::|.:|:|.:||||||||.:||..:|..||.:.:|||.
  Fly   445 VSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSIS 509

Human   501 SPYFV-YLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID 546
            :||.| .|||...::|..:.|...::..:|||.|||:....|.|.::
  Fly   510 APYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	156/562 (28%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	114/396 (29%)
CG6356	NP_651240.1	MFS	167..544	CDD:119392	114/392 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940