DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A5 and CG7333

DIOPT Version :9

Sequence 1:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	146/563 - (25%)
Similarity:	235/563 - (41%)	Gaps:	73/563 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-----SAW 62
            |:.:|....|.:|.||.:|..|...:.|.......|...:..||||.|...|...||     |.:
  Fly     2 DFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSVY 66

Human    63 RNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLST 127
            .|.:.           .||.          ..||:..|    .|.:........|.|:::....:
  Fly    67 ENISA-----------SSCT----------PLLGVVNG----TGVVSTNRKCRNWIFNRESGYES 106

Human   128 IVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFG 192
            |.||                      .:|  ||:......:..|.||:|.::|:.|.|.|||:.|
  Fly   107 ITTE----------------------LKW--VCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVG 147

Human   193 R-KNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST 256
            | .::|..|:...|| .|:..|......|.....:.|:...:.|...::|..|.|....|.....
  Fly   148 RLPSLLMATLCGATG-DFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLN 211

Human   257 LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 321
            :.:.:||.||.|..|..|.:|.:||..|...::|.:..:...:.|.||.:||:::.::::|.:.:
  Fly   212 IILAVFYCFGLMTSPWAAIWIGNWRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICL 276

Human   322 RKAAKANGIVVPSTIFD-------PSELQDLSSKKQQSH--NILDLLRTWNIRMVTIMSIMLWMT 377
            :|.||.|...|..::||       ..||||.   |..||  ..|.:..|..:|..|:..::..:.
  Fly   277 KKVAKFNRRHVEESVFDEFVKYYRERELQDY---KLNSHEDTFLAMFLTPRLRRFTLTLLVKSVI 338

Human   378 ISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSV----- 437
            |::....::.:...|....|.....:::|.:||.|...||...:.|:....||||:||.:
  Fly   339 ITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATG 403

Human   438 LLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 502
            .:...|.|.:...|..::|.:|:||.|.::.....|.||:.||.||...|..........|.|:.
  Fly   404 FMIAHLDPTENALLLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAF 468

Human   503 YFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 545
            |.:||..|.:.||.|.:..|....|.|.|.|||:....||:|:
  Fly   469 YVIYLAQYYKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	143/551 (26%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	106/386 (27%)
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	143/551 (26%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	106/376 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950