Protein Alignment SLC22A5 and CarT

DIOPT Version :9

• Sequence 1: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 176/560 - (31%)
• Similarity: 282/560 - (50%)
• Gaps: 45/560 - (8%)

Human     3 DYDEVTAFLGEWGPFQRLIFF-LLSASIIPNGFTGLSSVFLIATP-EHRCRVPDAANLSSAWRNH 65
            |.|::...:||:|.:|:|:.| :...:.||.||...:.:|:..|| ::.||:|:..:|....|..
  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99

Human    66 -TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES------CLDGWEFSQDV 123
             ::|..|.:...|...|..|.:    |::.| ||.|.:.||..:|..:      |..|||::..|
  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159

Human   124 YLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLS 188
            ..|:||.:.|                        |||:.|....:.::....|..:|.::.|.|:
  Fly   160 VWSSIVIDFD------------------------LVCDQDIYPTIGLAALNTGGPVGVYLFGLLN 200

Human   189 DRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRII 253
            ||.||:...||.:......|.:...||:|..:....|:||:...:.|...|::..|::|::.| .
  Fly   201 DRGGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-S 264

Human   254 FSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAE 318
            |.|:..|.||..|.|:|....|..|||..|....::|........:.:|||||||:.:||.|||.
  Fly   265 FVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEAL 329

Human   319 VIIRKAAKANGIVVPSTIFDPSELQ----DLSSKKQQSHNI--LDLLRTWNIRMVTIMSIMLWMT 377
            .|:.:.||.||...|..:....|.|    .|..:|::..|:  .||.||.|:|:.||:..:.|..
  Fly   330 KILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFA 394

Human   378 ISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQ 442
            ....|.|||...|.|..:.:|:.||||:||:|:|:..|..:....||:.::.::.|||...:...
  Fly   395 NETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITV 459

Human   443 LVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 507
            ::|.|......||.:|.|..::|:|.::|.:..|||||.||.:|:|.||....||.|..|:..||
  Fly   460 MLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYL 524

Human   508 GAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 547
            |..:..||.::||.|::|..:..|.|||:....||.||::
  Fly   525 GKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEE 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	172/546 (32%)
		MFS	162..534	CDD:119392	124/377 (33%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	172/546 (32%)
		MFS	182..551	CDD:119392	123/369 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9141
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3605
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880