DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A4 and CG6356

DIOPT Version :9

Sequence 1:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	162/545 - (29%)
Similarity:	251/545 - (46%)	Gaps:	66/545 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    11 LGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHR-CRVPDA--ANLSSAWRNNSVPLRLR 72
            :|..|.|...||||.....|.|||:..|...|...|:.: |.:|:.  .|.:.|.:...|...|.
  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAKGLD 95

Human    73 DGREVPHSCSRY-----RLATIANFSALGLEPGRDVDLGQLEQESC-LDG-WEFSQDVYLSTVVT 130
            .|     .|:.:     .||.::..:||.. .|....:....:.|| :.| .||:...  :|.|.
  Fly    96 SG-----GCTVWDWNYGHLAKMSYEAALNY-TGHLTQISPPAEVSCRVKGQHEFAHPE--TTFVA 152

Human   131 EWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEM 195
            :|:|.|:.:.:.........:|...|||..|.|:|:||||:......|.....||...||..:.:
  Fly   153 DWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSL 217

Human   196 FTVLFVIVGMGQISNYVVAFILGTEILGKSVR----IIFSTLGVCTFFAVGYMLLPLFAYFIRDW 256
            |......:|......:..||.:..|.:....|    |.||     ..:.||.::|.:..|.|:.|
  Fly   218 FLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFS-----ASYPVGMIILAIVGYVIQPW 277

Human   257 RMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDI---------IQKAAKMNNIAVPAVI 312
            |.|.||||:|.:|.:...:.:.|||||||:.:|:.....|         ||.|     :|.|:.:
  Fly   278 RHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPA-----VAAPSQV 337

Human   313 FDSVEELNPLKQQKAF-------------ILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAP 364
            ....:.|.|   ::.|             |::|:....:..|...|..::.:||:.|:..:|:|.
  Fly   338 ASDKKSLEP---EEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAA 399

Human   365 NLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGL 429
            ||....||....:.|::||:|:...::||...||.....:..|.|..||.:..||.......:..
  Fly   400 NLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAF 464

Human   430 VMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV-YLGAYNRMLPYIVM 493
            .|||:|||::.:|::.::|||||||.:||.|:|..||.:.||||.|||.| .|||....:|..:.
  Fly   465 AMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTIC 529

Human   494 GSLTVLIGILTLFFPESLGMTLPET 518
            |...::.|:|||        |||||
  Fly   530 GCCVLVAGLLTL--------TLPET 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	160/542 (30%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	125/411 (30%)
CG6356	NP_651240.1	MFS	167..544	CDD:119392	121/397 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940