DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A4 and Orct

DIOPT Version :9

Sequence 1:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens
Sequence 2:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	202/563 - (35%)
Similarity:	301/563 - (53%)	Gaps:	56/563 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     4 YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP----DAANLSSAWRN 64
            ||:||..|||:||:|:.|::||....|...|:.::.|||...|:.||.:|    ....||....|
  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWN 67

Human    65 NSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDL------GQL-----EQESCLDGWE 118
            .|.|...|        ||.|                 |||.      |.:     |.::| ..:.
  Fly    68 LSYPENER--------CSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106

Human   119 FSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGF 183
            :.:..||::.||||||||..:.....:.|||.:||||||.:.||:||:.|||...||::.:|..|
  Fly   107 YDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIF 171

Human   184 SFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPL 248
            ..|...:..:..:|:..:|||......::||:::..|::|.|.| :|:.:.:..||:||:||...
  Fly   172 GVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVAMQMFFSVGFMLTAG 235

Human   249 FAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIF 313
            |||||.|||.|.:|:|:||:|.:..:|.||||.|||:.:.|..||..||:||||.|.:.||..|:
  Fly   236 FAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIY 300

Human   314 DS-VEELNPLKQQ--------KAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGD 369
            :. |:|:...|:|        .|.:.||.|..|:...|::....|.:.|..|:.||.:..||.|:
  Fly   301 EQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGN 365

Human   370 AYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGK 434
            ..:|..:|..:|||.|......|....||.|:...:...|..||....||.|..:|.:...|:||
  Fly   366 QLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGK 430

Human   435 FGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVL 499
            ..|||::..:|:|:||.:||:|||:.:|.:|..:|||.|:|||...||...|.||.|:.|:|::.
  Fly   431 LAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLT 495

Human   500 IGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEE 542
            .|:|:|..||:|...:|||:|..:..     |||.......||
  Fly   496 AGLLSLLLPETLNKPMPETIEDGENF-----GKKPAPQETAEE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	189/529 (36%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	153/393 (39%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	189/529 (36%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	138/356 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153481
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3558
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8592
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.720