Protein Alignment SLC22A4 and CG7084

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_651016.1
• Gene: CG7084 / 42606
• FlyBaseID: FBgn0038938
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 544
• Identity: 163/544 - (29%)
• Similarity: 270/544 - (49%)
• Gaps: 64/544 - (11%)

Human    12 GEWGPFQRLIFFLLSASIIPNGFNG----MSVVFLAGTPEHRCRVPDAANLS---SAWRNNSVPL 69
            |..|.:|.|..|:....:   .|:|    |:::.....|:|.|.||...|.:   ..||:.::|.
  Fly    42 GNHGRYQTLYNFVFVGGL---AFSGAMIYMNIILALNIPDHWCTVPGRENTNFSLEEWRDITLPK 103

Human    70 RLRD-GREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWN 133
            :..: ||:...:|..:::    |||.:......:.:|.: ..|:|.:||.:.:..|.||:.|:.|
  Fly   104 QADNRGRKTFSNCEMFQM----NFSEITDWSAWNSNLTK-TTEACQNGWSYDKTWYESTIPTDHN 163

Human   134 LVCEDNWKVPLTTSLFFVG---VLLGSFVSGQLSDRFGRK-----NVLFATMAVQTGFSFLQIFS 190
            .||.   |....|::|.||   .:.|||:.||:.|.:||:     :|:|.::. :.| |.:...|
  Fly   164 WVCA---KDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLG-RLG-SIMCTSS 223

Human   191 ISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR---IIFSTLGVCTFFAVGYMLLPLFAYF 252
            .:|  |.::..|||:...|.:....|:|.||..:..|   ..|.:.|    :::|..|:||..::
  Fly   224 YTW--FLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCG----WSIGTTLMPLLYWW 282

Human   253 IRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE 317
            :|.|...:...::|..:.:....::.||||||||::|||||...:||.||:|...     ||..|
  Fly   283 LRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHR-----FDMTE 342

Human   318 -ELNPL----KQQKAF-ILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFL 376
             ||..:    ||...: |..||....:|..|.:....|.:.:|.||.|.|.:..:.|:.:||...
  Fly   343 KELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLY 407

Human   377 SALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYF-------LSIGLVMLGK 434
            .:::|||||:....:..|..||: ..:|.|    ::.|:..:|:..|.       |.|.|....|
  Fly   408 QSIVEIPAYVVGRYMGDTYGRRF-TNSVSF----LISFVTCLPIIVYSTDERYENLMIYLATFIK 467

Human   435 FGITSAFSMLYVFTAELYPTLVRNMAVGV-TSTASRVGSIIAPYFVYLG-AYNRMLPYIVMGSLT 497
            |.....|..:.:...|:|||.:|...|.: |..|:.:| ::|||.|||| ..:...||.::|.|.
  Fly   468 FLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIG-VLAPYLVYLGTTVDIRAPYYILGVLF 531

Human   498 VLIGILTLFFPESLGMTLPETLEQ 521
            :|.||..||.||:|...||:|:|:
  Fly   532 LLGGIGALFLPETLHKKLPDTMEE 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	161/539 (30%)
CG7084	NP_651016.1	MFS_SLC22	146..542	CDD:340875	130/417 (31%)