Protein Alignment SLC22A4 and CG4459

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 591
• Identity: 121/591 - (20%)
• Similarity: 239/591 - (40%)
• Gaps: 108/591 - (18%)

Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTP---EHRCRVPDAANLSSAW-- 62
            :.|.|....|.:|.:|.....|:....||:.:....:::.|..|   |..|. |...|:|.:.
  Fly    17 ELDVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCH-PADWNVSRSQTE 80

Human    63 ---RNNSVPLRLRDGREVPH-----SCSRYRLATIANF---------SALGLEPGRDVDLGQLEQ 110
               ||:  || .:|.|....     .|:.|..:....|         ::...|||....|.....
  Fly    81 HVDRNH--PL-WQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEHV 142

Human   111 ESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFA 175
            |...|         ..:::::::|:|.....|.||.|...:|.|:|..::.....:...:.::..
  Fly   143 EHRTD---------YKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLL 198

Human   176 TMAVQ------TGFSFLQIFSISWEMFTVLF--VIVGMGQISNYVVAFILGTEILGKSVRIIFST 232
            .|..|      ||........|.:...|.:|  ::...||       |||.....||: |||..|
  Fly   199 GMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQ-------FILNDITSGKA-RIIVVT 255

Human   233 LGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDII 297
            |.. .|:::|.:|||..:.:..:|..|.:|::...::.|.|..:|.::||||:..:|...|...:
  Fly   256 LSE-LFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQL 319

Human   298 QKAAKMNNIAVPAVIFDSV----EELNPLKQQKAFILDLF-----RTRNIAI-------MTIMSL 346
            .::|..||..||..:...:    .:|:...:||.....::     |::.:.|       |.:.::
  Fly   320 LESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNI 384

Human   347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIE-IPAYITAWLLLRTLPRRYIIAAVLFWGGG 410
            :|.|:.::|       |..:|    :|.......| :..::..:|:|.|  ||:     ..|.|.
  Fly   385 ILLMIRNLG-------AQQVH----VNTAAMGFAEMVGLFVGLYLILYT--RRH-----WRWAGN 431

Human   411 VLL-------FIQLVP-VDYYFLSIGLV----MLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463
            :::       .|.|:| .:.....:||.    ::.|...:::.::|...|:|:.....|.:.:..
  Fly   432 LMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLS 496

Human   464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGI----LTLFF-----PESLGMTLPETL 519
            ..:.|||..:..|:...|...:.::|..::.::..:.|:    |..::     |:...:..|.|.
  Fly   497 VISFSRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNTY 561

Human   520 EQMQKV 525
            .:...:
  Fly   562 RRQSAI 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	118/573 (21%)
CG4459	NP_650850.1	MFS_SLC22	139..540	CDD:340875	89/436 (20%)