Protein Alignment SLC22A4 and CG4465

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 111/559 - (19%)
• Similarity: 197/559 - (35%)
• Gaps: 123/559 - (22%)

Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSV 67
            |.|.:...:|.:||:|               ...:.::||       |::|      :||....:
  Fly    58 DDDVITHIMGNFGPWQ---------------LRSLLILFL-------CKIP------AAWFMACI 94

Human    68 PLRLRD-GREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVY------- 124
            .....| ..|..:.|         :.:|.|.:....|.|     :.|.....:.:..|
  Fly    95 LFTAPDLYPEEEYKC---------DTTAFGPDVNSTVSL-----DHCYVMVNYGESAYAMRQCRK 145

Human   125 ------LSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGF 183
                  ..::..|::|||..::.|..:......|:|:|...:.:|      ..||......:||.
  Fly   146 FLYTTGFHSLTMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKL------MRVLSPRQIYRTGI 204

Human   184 SFLQIFSISWEMFTVLFVIVGMGQISNYVVAFIL--GTEILGK----SVRIIFSTLGVCTFFAVG 242
            ..|.:.|:...:.....:..|:..::.....|::  |..|.|.    ..|:....|..| |:|:|
  Fly   205 WCLLMCSLLMGLVKDFSLHCGLRCLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDC-FWALG 268

Human   243 YMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLI-----SQRRFREAEDIIQKAAK 302
            .:|||..|.....|:.:.|.:|:..::.|.|..:.|:||||.:     :|........|:.:||:
  Fly   269 LILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAAR 333

Human   303 MNN--IAVPAVIFDSVEE-----LNPL-----------KQQKAFILDLFRTRNIAIMTIMSLLLW 349
            .|.  ..|...:...:||     |.|:           :::..|.|..........|.:.:.||.
  Fly   334 TNGRMHKVSKELPQQLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMVVNTGLLL 398

Human   350 MLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLF 414
            .:.|.|...|..:...:.....|.|||:..:........|.                |.||..:.
  Fly   399 HVRSFGREHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQ----------------WAGGFAIV 447

Human   415 IQLV------------PVDYYFLSIGLVM--LGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTS 465
            :..:            | :.|.|::||:|  |.:..:..|.||:.....||.|...|:.......
  Fly   448 VGCIGSICWFLAEEDMP-EVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSCLSFSAV 511

Human   466 TASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILT 504
            |.:||..:.|.:...|...:..|.......|.:|.|:.|
  Fly   512 TWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGLGT 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	109/550 (20%)
CG4465	NP_650847.1	MFS_SLC22	143..553	CDD:340875	90/432 (21%)