DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A4 and CG7333

DIOPT Version :9

Sequence 1:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens
Sequence 2:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	150/550 - (27%)
Similarity:	236/550 - (42%)	Gaps:	63/550 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLS-----SAW 62
            |:.:|:...|.:|.||.:|..|...:.|....:..|...:..||||.|...|...||     |.:
  Fly     2 DFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSVY 66

Human    63 RNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLST 127
            .|.|.           .||:          ..||:..|    .|.:........|.|:::....:
  Fly    67 ENISA-----------SSCT----------PLLGVVNG----TGVVSTNRKCRNWIFNRESGYES 106

Human   128 VVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGR-KNVLFATMAVQTGFSFLQIF-- 189
            :.||...||:.:....:..|.||:|.::|:.:.|.|||:.|| .::|.||:...|| .|:..|
  Fly   107 ITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATG-DFITSFVH 170

Human   190 SISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIR 254
            ::.|..|:..  :.|:...:.|.:.:||..|.|....|.....:.:..|:..|.|..|..|.:|.
  Fly   171 TLPWFAFSRF--MSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIG 233

Human   255 DWRMLLLALTVP--GVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV- 316
            :||..|...::|  |||..|  :.|.||.:||:::|::.:|...::|.||.|...|...:||..
  Fly   234 NWRRYLWLASLPALGVLIYP--FLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFV 296

Human   317 -----EELN--PLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH----GDA 370
                 .||.  .|...:...|.:|.|..:...|     |.:|.......||.|..|.:    |.:
  Fly   297 KYYRERELQDYKLNSHEDTFLAMFLTPRLRRFT-----LTLLVKSVIITLSCDVINRNMEGLGTS 356

Human   371 YLNCF-LSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGV-----LLFIQLVPVDYYFLSIGL 429
            ....| .::::.:||.:...||...:.|:.:....||.||.:     .:...|.|.:...|...:
  Fly   357 PFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIM 421

Human   430 VMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMG 494
            |.||:||.|.::.....:.||:.||.||..||..........|.:|.|.:||..|.:.||.|.:.
  Fly   422 VGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFIS 486

Human   495 SLTVLIGILTLFFPESLGMTLPETLEQMQK 524
            .|......|.|..||:|...|||||...:|
  Fly   487 CLMFFGAGLCLTLPETLNKKLPETLADGEK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	144/533 (27%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	112/407 (28%)
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	144/533 (27%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	108/382 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950