Protein Alignment SLC22A4 and CG12783

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_001262644.2
• Gene: CG12783 / 42019
• FlyBaseID: FBgn0038448
• Length: 493
• Species: Drosophila melanogaster
• Alignment Length: 447
• Identity: 81/447 - (18%)
• Similarity: 176/447 - (39%)
• Gaps: 98/447 - (21%)

Human   146 TSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVL-FV----IVGM 205
            |:..|:|::..|:..|.::|:.||:..|..|:.:....|...:|::::..|.|: |:    :.|.
  Fly    60 TAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGP 124

Human   206 GQISNYVVAFILGTEILGKSVRIIFSTLGV----CTFFAVGYMLLPLFAY--------FIRDWRM 258
            ..::...::......|:.:|:..::...|.    |..:|..::...|..:        .:|.||:
  Fly   125 SFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIEFEEKLVGSLTLRPWRV 189

Human   259 LLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPA-------VIFDSV 316
            |.....:|||:...|...:||||::|:.....:...|.::..::.|.....:       :.:...
  Fly   190 LGCLYILPGVVAFLLLLLLPESPKFLLMIGETKRGLDTMEWISRKNTGRTLSEDQMKRLLAYQEH 254

Human   317 EELNPLKQQKAF---ILD----LFRTRNIAIMTIMSLLLWML------TSVGYFAL----SLDAP 364
            .::...|:.:.|   :||    |.|.......|.:.:::::|      ..:.|.|:    ::...
  Fly   255 VQVKRRKEHQNFFRSMLDDAMPLVRKPYGGYFTCVCMVMFVLGLLTHGLGIWYTAMRNRCNMRQG 319

Human   365 NLHG--------------------DAYLNC----------FLSALIEIPAYITAWLLLRTLPRRY 399
            |.:|                    |..:.|          |:...:.:..|..:|..|..:.::.
  Fly   320 NTNGMTFCQVLFVPETGPFIETESDLDVVCSDSFKGFNDSFVLGFVYVVLYNISWASLFCVHKKV 384

Human   400 -----IIAAVLFWGGGVLLF-----IQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPT 454
                 ::|:..|  |.:|:|     :||..:.:.....|:: :|..|     ..|.||.    ||
  Fly   385 MFVFSLVASSTF--GFLLIFATNHMLQLFSLVFLIAFPGII-IGLLG-----GSLLVFV----PT 437

Human   455 LVRNMAVGVTSTASRVGSIIAPYFVYLGA---YNRMLPYIVMGSLTVLIGILTLFFP 508
            .:|..|:.::....|.|:......|  |:   ||..|..:.:..|.::...:..:.|
  Fly   438 YLRGKALCISLMWCRCGAAFGAMLV--GSKIQYNCELFLLAISILPLIAACMEGYLP 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	81/447 (18%)
CG12783	NP_001262644.2	synapt_SV2	<2..>310	CDD:130366	46/249 (18%)