Protein Alignment SLC22A4 and CG44098

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_001262264.1
• Gene: CG44098 / 40590
• FlyBaseID: FBgn0264907
• Length: 813
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 134/542 - (24%)
• Similarity: 226/542 - (41%)
• Gaps: 60/542 - (11%)

Human     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHR---CRVPD--AANLSSAWRN 64
            |.|....|.||.:|.....|:....||:.:....::|.|..|.|.   |:.|.  .|...:.|..
  Fly   207 DAVGQITGPWGKWQLRTVLLIFLCKIPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQTQWIK 271

Human    65 NSVPLRLR-DGREVP-HSCSRYRLAT-----IANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122
            .|.|.:.. |.:|.. ..|:.|:.|.     ..|:.....|| |..:.......:.:...||..:
  Fly   272 VSHPQKEESDDQEFSIDFCNVYQDAQEHAHHYYNYENSDQEP-RVWEKPLHRNSNVIPCTEFQHE 335

Human   123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQ 187
            ....:|||:::|||..:..|.:|......|||.|..::.||...|..:||:...|..|.....|.
  Fly   336 SDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSPRNVMLFGMITQIFCGNLT 400

Human   188 IFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYF 252
            ....|:|:......:..:.....|.....:..:|.|...|...||| ...|:::|.|:||..|.|
  Fly   401 GHVASYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTL-FEQFWSIGVMMLPGVASF 464

Human   253 IRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIA--VPAVIFDS 315
            ...|..|.:|::.|.|:.:.||.:||:||||||::.|.::|:.|:.:..::|...  :|..|...
  Fly   465 WSSWSHLYMAISWPTVILIYLWQWIPDSPRWLIARGRTQDAKKILLECVEVNGTGYNLPHDIDQQ 529

Human   316 VEELNPLKQQKAFILD---------LFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGD-A 370
            :|    |:.|.|  :|         :::........:...|.|.|..|.|:.:.|:..:...| .
  Fly   530 LE----LQAQTA--MDAPPPSGWWSMWKGERAVRHIVCVHLAWSLYIVVYYGMLLNIRSFSRDHL 588

Human   371 YLNCFLSALIE-IPAYITAWLLLRTLPRRYIIAAVLFWGG------GVLLFI-QLVPVDYYFLSI 427
            |:|.|.:...| :..:...:|:|:| .|:::      |.|      |.:.:. .|||....   |
  Fly   589 YINTFFAGFSEMMGTFFGLFLILKT-TRKWL------WTGLFNIVAGCIAYCGWLVPKPSV---I 643

Human   428 GL----------VMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLG 482
            ||          .|:.|..|::..|:|...|.||.....:.:....|...:|...:.||:.....
  Fly   644 GLDPNVALLMCSAMVSKMAISTTLSILTTCTVELVSDDKKKITSFSTICWARFWLLGAPFIGSTV 708

Human   483 AYNRMLPYIVMGSLTVLIGILT 504
            .:.:::|.....||.:|.|:.|
  Fly   709 VFGQLIPQTAFASLAILGGLCT 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	132/535 (25%)
CG44098	NP_001262264.1	MFS_SLC22	329..732	CDD:340875	106/419 (25%)