Protein Alignment SLC22A4 and CG7458

DIOPT Version :9

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 156/537 - (29%)
• Similarity: 267/537 - (49%)
• Gaps: 38/537 - (7%)

Human     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPL 69
            |.::..:|::|.:|.:.:.||...::.|.|..:|.||.|.|..|||.||...:.||.:..:.:..
  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103

Human    70 RLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQ---LEQESCLDGWEFSQDVYLSTVVTE 131
            .:.........|.|| .|.|::..:...:|.....|.:   :..|:|...::|..:.  .|:.||
  Fly   104 TIPKKNSAWDDCHRY-AANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE--KTISTE 165

Human   132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMF 196
            :.:.|||.||:.:..::..||..:|..:.|..:||:||:.:|....:|......::..|.::.||
  Fly   166 FGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMF 230

Human   197 TVL-FVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLL 260
            .|. |:.:.:|. :.:..||:|..|::|...|:..:|: :..|:|:|...|...|..::.||.||
  Fly   231 LVFEFLDMAVGS-TLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGFLASQVQHWRWLL 293

Human   261 LALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPL--- 322
            ..|..|.||.:...|.:|||.|||:||....:|.:::::||::|...:|.      |:||.|
  Fly   294 RVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPE------EQLNDLLTS 352

Human   323 KQQK-------------AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNC 374
            .:||             |.:....|..|..       |.|...::....|||::.||.|:.|.|.
  Fly   353 NRQKLSQANESQYPIMRAVVFFSLRIANCC-------LCWFTHTLIALGLSLNSVNLGGNKYTNF 410

Human   375 FLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITS 439
            .|:..|:||..:...:::..:.||:.:.|.:......:.....||.|.|..|:.|.::||..||.
  Fly   411 MLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITC 475

Human   440 AFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILT 504
            :|.:||.||:|::||.|||..:.:.|...|:||::||....|..|....|.|:..:..::.|.||
  Fly   476 SFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLT 540

Human   505 LFFPESLGMTLPETLEQ 521
            |.|||:....||.|:|:
  Fly   541 LAFPETADKVLPTTIEE 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	153/525 (29%)
		MFS	123..508	CDD:119392	119/401 (30%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	153/525 (29%)
		MFS	161..544	CDD:119392	119/397 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.980