Protein Alignment SLC22A4 and CG8654

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_611451.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 146/548 - (26%)
• Similarity: 246/548 - (44%)
• Gaps: 85/548 - (15%)

Human     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPL 69
            |.:|:.:|::..:|...||::.......|::.:..:|||......|:.
  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKT----------------- 69

Human    70 RLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNL 134
                 ..|...||                            :.|.: .||...|:.||::|||||
  Fly    70 -----ENVTDPCS----------------------------DECSE-TEFDTSVFQSTIITEWNL 100

Human   135 VCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ--TGFSFLQIFSIS---WE 194
            .||......|:.|:..:|:|.||.:.|..:||:||:........:|  ||.    |..:|   |
  Fly   101 TCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGL----IVCVSPYYW- 160

Human   195 MFTVLF-VIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRM 258
             |..|| .:|.:........:|:|..||:|...|.:.:.|.... |.:|:..|.|||||||:||.
  Fly   161 -FYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIP-FNIGHASLALFAYFIREWRW 223

Human   259 LLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAV------IFDSVE 317
            ...::|:..::.|...|.:|||||||.:..:..::..|::|.||.|......:      .:.::.
  Fly   224 FQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALA 288

Human   318 ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEI 382
            ...|:|  |..::|||||..:.|.||.....|::..:.|:..:.....|.|:.:::..::|.:.|
  Fly   289 ARQPVK--KGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGI 351

Human   383 PAYITAWLLLRTLPRRYIIAAVLFWGGGV----LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSM 443
            |......|:.:.|.|:    ..|....|.    |:.:..:......:.:....:|.||.:..|..
  Fly   352 PGTCLCALMTKYLGRK----KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPN 412

Human   444 LYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFP 508
            :|::..||:||:||:..||:.|...|:|||:||..|.|.||...:..::.|..::|..:.|:|.|
  Fly   413 VYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLP 477

Human   509 ESLGMTLPETLEQMQKVKWFRSGKKTRD 536
            |:.|..||||||..:..     |:|.:|
  Fly   478 ETRGTPLPETLEDGETF-----GRKKKD 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	137/521 (26%)
CG8654	NP_611451.1	MFS_SLC22	82..477	CDD:340875	119/408 (29%)