Protein Alignment SLC22A4 and Balat

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_610823.1
• Gene: Balat / 36417
• FlyBaseID: FBgn0033778
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 185/569 - (32%)
• Similarity: 295/569 - (51%)
• Gaps: 75/569 - (13%)

Human     3 DYDEVIAFLGEWGPFQRLIF--FLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAW--- 62
            |:|||:..:|.:|.:|::|.  .||.|: :|..|:..|.:|:|.||:|.||||:.    ..|
  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAA-LPCAFHAYSQLFIAATPQHFCRVPEL----EPWTQD 61

Human    63 -----RNNSVPLRLRDGREVPHSCSRY--RLATIANFSALGLEPGRDV------DLGQLEQES-- 112
                 :|.|:| |.|:|...  .||.|  ....|..:  |...|..|:      ||.:|:.::
  Fly    62 YVQLVKNLSIP-RNRNGAYA--ECSMYSRNYTDIVRY--LEYRPPPDLLRQQAEDLLKLQPDTTQ 121

Human   113 ---CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF 174
               |..||.:.:.:|.||||.||||||:.::.|.|...:|.||.|||::|.|.|.|.:||:...:
  Fly   122 VVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFY 186

Human   175 ATMAVQTGFSFLQIF-----SISWEMFTVLFV--IVGMGQISNYVVAFILGTEILGKSVRIIFST 232
            |       :..|:|.     :.:|..:|.|.:  :||:...:.....::|..|::|.. |.:|.|
  Fly   187 A-------YLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPE-RRVFCT 243

Human   233 LGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDII 297
            :.....:::|.::|....|.:||||.|.||:::|.::....::.:|||||||::..:.|.|..|:
  Fly   244 IVSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKIL 308

Human   298 QKAAKMNNIAVPAVIFDSVEELNPLKQQKAF----------------ILDLFRTRNIAIMTIMSL 346
            :..|::|.:.|..   |.||.|    |:|..                ||||||..|:...|::..
  Fly   309 KVMARVNGVRVNR---DFVERL----QRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIIT 366

Human   347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGV 411
            |:|...:..|..||..||.|.||...|.||:..:|:|.|:..|..|....||:|:...:..||..
  Fly   367 LIWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVA 431

Human   412 LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476
            .:...|.|    .:::.|..:||.||:|:|.:|.:..:|||||:||.:.:..:|..|.||.|:.|
  Fly   432 CVATFLYP----DITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP 492

Human   477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKV 525
            ...::|....:||.||||:|.:|.|..:|..||:....||:|||:.:.|
  Fly   493 MINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAV 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	177/551 (32%)
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	136/414 (33%)