DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A4 and CarT

DIOPT Version :9

Sequence 1:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens
Sequence 2:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	172/562 - (30%)
Similarity:	294/562 - (52%)	Gaps:	26/562 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     3 DYDEVIAFLGEWGPFQRLIFF-LLSASIIPNGFNGMSVVFLAGTP-EHRCRVPDAANLSSAWRNN 65
            |.|:::..:||:|.:|:|:.| :...:.||.||...:.:|:|.|| ::.||:|:..:|....|.:
  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99

Human    66 -SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES------CLDGWEFSQDV 123
             |:|..|.:...|...|..|.:    |::.| ||.|.:.||..:|..:      |..|||::..|
  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159

Human   124 YLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQI 188
            ..|::|.:::|||:.:....:..:....|..:|.::.|.|:||.||:...|..:|.....|.:..
  Fly   160 VWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTS 224

Human   189 FSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI 253
            .|..:..:....||||:...:.|.:.||:..|::|::.| .|.|:..|||:..|.|||....|..
  Fly   225 LSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-SFVTVMTCTFYTSGIMLLSGVTYLE 288

Human   254 RDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE- 317
            |||..|....::|........:.:|||||||:.:.|..||..|:::.||:|....|..:...:|
  Fly   289 RDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEA 353

Human   318 --ELNPLKQQK-----AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCF 375
              ..:.||:||     ..:.||.||.|:.:.||:..|.|......|..||...|.|..:.|::.|
  Fly   354 QIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFF 418

Human   376 LSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSA 440
            |||::|:|:|:..|..:.|..||:.::..:..||...:...::|.|....::.|.::.|..::::
  Fly   419 LSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSAS 483

Human   441 FSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTL 505
            |.::|.|..|||||.||.:.:|.:|....:|.|..|:..|||..|..||.::||.|::|.|:..|
  Fly   484 FLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGL 548

Human   506 FFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVL 547
            ..||:|...||:|:|:.::   |....:.:|.....:.|::|
  Fly   549 RLPETLHHRLPQTIEEGEE---FGKNWQFKDCCRCAQKPEIL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	164/522 (31%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	122/392 (31%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	164/522 (31%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	116/369 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9141
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930