Protein Alignment SLC22A4 and CG31272

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_650013.3
• Gene: CG31272 / 326130
• FlyBaseID: FBgn0051272
• Length: 563
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 110/498 - (22%)
• Similarity: 193/498 - (38%)
• Gaps: 127/498 - (25%)

Human   120 SQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFS 184
            |....|.....:..|..||.   .:..::.:.|:.:.:...|.|:|..|||.:|:....:.....
  Fly    78 SMSYILPIAECDLRLTLEDK---GVLNAVAYAGMTISAIAWGYLADTKGRKKILYWGYLIDAVCV 139

Human   185 FLQIFSISWEMFTVLFVIVGMGQISN--YVVAFILGTEILGKSVR-IIFSTLGVCTFFAVGYMLL 246
            |....|.::.|. |:|..:| |.:.|  ..|.|...||:.|...| .:...:|:.|..|.  :.|
  Fly   140 FGSALSQNFSML-VMFKFLG-GLVVNGPAAVLFTYLTEMHGPKHRSSVLMIVGMVTSTAT--VSL 200

Human   247 PLFAY--FIRD------------WRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREA---- 293
            ||.|:  |.||            |::.|..|.:|.::...::..:|||||:|::|.|..||
  Fly   201 PLLAWGIFPRDWDFEFWGLQVHSWQIFLFVLGIPSLISGLIFCSMPESPRFLMAQGRNEEALQAF 265

Human   294 -----------------EDIIQKAAKMNNIAVPAVIFDSVEELN---PLKQQKAFILDLFRT--- 335
                             :.:||:..  |..|....:..::||.:   |.|:|...:.:..|.
  Fly   266 KQIYHVNTRKPKDSYPIKALIQEVP--NRKAAQNEVIYTIEEKSGEVPTKRQSRTLAESLRAGLQ 328

Human   336 ----------RNIAI----------MTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALI 380
                      ..:||          :.:.::.||:   ...||...:...||....|:..:..::
  Fly   329 QMKPLVRKPLLGLAICCYVMQFGIFLGMNTIRLWL---PQLFASMAEYEALHAGDGLDVSMCTIL 390

Human   381 EIPAYITAWLLLR-----TLPR---------RYIIAAV----LFWGGGVLLFIQLVPVDYYFLSI 427
            |.....||...|.     :.|:         ..|::|.    .|:.||:|.  .|.|  ...::.
  Fly   391 EFSVNQTAETALNYADACSEPKVISMDMYLNNIIVSATGFVGYFFAGGILR--ALGP--KRMMTY 451

Human   428 GLVMLGKFGITSAFSMLYVFT----------------------AELYPTLVRNMAVGVTSTASRV 470
            ||.:.|.||:...||:..:.|                      ..|:||.:|.:.|.:.....|.
  Fly   452 GLFLSGTFGLMLYFSVSSLMTLIVSATFLTITGIAVSSLLGAVVALFPTQLRTVVVAIAMMCGRF 516

Human   471 ----GSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPE 509
                |:::.|.||..|.   :.|:|::.|:.:|.|||::..|:
  Fly   517 GALSGNLLFPVFVQTGC---LPPFIMVSSVLILSGILSISLPD 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	110/498 (22%)
CG31272	NP_650013.3	synapt_SV2	15..556	CDD:130366	109/496 (22%)