Protein Alignment SLC22A4 and CG3168

DIOPT Version :10

• Sequence 1: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_572345.1
• Gene: CG3168 / 31612
• FlyBaseID: FBgn0029896
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 474
• Identity: 105/474 - (22%)
• Similarity: 184/474 - (38%)
• Gaps: 113/474 - (23%)

Human   122 DVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF-----------A 175
            |:.|:|....|            ..|:.|:|:::|::..|.::|.||||.||.           |
  Fly   181 DLDLNTETKGW------------LNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVA 233

Human   176 TMAVQTGFSFLQIF------------SISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR- 227
            :...|| :||..:|            .:.|..|.........|.:.:::.||.....:...|:.
  Fly   234 SSFSQT-YSFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAW 297

Human   228 -IIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFR 291
             ||..|:|..|         |.|.|  ..||:.||..::|..|...|.:::||||::|:::.:..
  Fly   298 LIIPRTIGFTT---------PYFTY--NSWRIFLLVCSLPSFLVGFLLFYLPESPKFLLTRGKKD 351

Human   292 EAEDIIQKAAKMNNIAVP--AVIFD-SVEE---------LNPLKQQKAFILD----LFRTRNIAI 340
            .|..|.:.....|....|  .:::| .|:|         .|...:..:.::|    ||:: .|..
  Fly   352 RALAIFRGIFVTNTKRRPDEYMVYDLEVDEKLLESNGNVKNKYSRMISGMVDHSRALFKS-PILR 415

Human   341 MTIMSLLLWMLTSVGYFALSLDAPNL--------------------------------------H 367
            .||:|:.:.....:||:.|.:..|.|                                      .
  Fly   416 FTIVSITINFTFHIGYYGLLMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKEQSNNGTCS 480

Human   368 GDAYLNCFLSALIE----IPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIG 428
            .|...:.|:.:||.    :||.:.|.|.:..|.|::.:.|.....|.....:..|......|.:.
  Fly   481 SDIPQSVFMESLISLASALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVRSSVQNLVVS 545

Human   429 LVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV--YLGAYNRMLPYI 491
            .:..|  .|::|.:.|.....|::||.:|...|.::..|:|:|.||....:  .|..|.....:|
  Fly   546 AIFSG--AISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFI 608

Human   492 VMGSLTVLIGILTLFFPES 510
            |.| |.:..|::.|..|.:
  Fly   609 VSG-LLIGGGLMCLLLPNT 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	105/474 (22%)
CG3168	NP_572345.1	synapt_SV2	<137..626	CDD:130366	105/472 (22%)