Protein Alignment SLC22A2 and CG4459

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 108/559 - (19%)
• Similarity: 212/559 - (37%)
• Gaps: 100/559 - (17%)

Human     7 DVLEH-GGEFHFFQKQ---MFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLR-CGWS 66
            ||:|. .|.|..:|.:   :.||..:.||.|..|.:      :|..:    |...||... ..|:
  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIII------YTAPY----PWKGELVCHPADWN 73

Human    67 PAEELNYTVPGPGPAGEASPRQCRRYEVD--------------------WNQSTFDCVDPLASLD 111
            .:......|....|..:.:....|.:.||                    ||.|
  Fly    74 VSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNAS------------ 126

Human   112 TNRSRLPLG----PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIAD 172
              :|:.|.|    || :...:.|...|::::|:|:|:...::.|.||...:|..||.:.......
  Fly   127 --QSKEPGGQSSLPC-EHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALK 188

Human   173 RFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTV 237
            :...:..:|..::.....|.|..:..||...:.||.:..:.....:..|..::.:....:.|..|
  Fly   189 KISPRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARIIV 253

Human   238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFL-LYYWCIPESPRWLISQNKNAEAMR 301
            ....::.:::||::|..::....:|.:|...:|......: |:.| |.::||||:...:...|:|
  Fly   254 VTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRW-IADAPRWLLQHQRVEAALR 317

Human   302 IIKHIAKKNGKSLPASLQ-RLRL---EEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLY 362
            .:...|..|.:.:|.:|. :|.:   :.:...|...|:..:......|...:.:...|..:.|||
  Fly   318 QLLESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLY 382

Human   363 Q-GLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNM-VAGAACLASVFIP 425
            . .|:|...|....::::.......|....|:.:..|....|.:.||.:.| :||.:......:|
  Fly   383 NIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLP 447

Human   426 GD-----------LQWL----------KIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHI 469
            ..           :.||          .::.:|...: ::....:|.:::.   .:|.|     :
  Fly   448 ETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEI-VSKEKRVVLMLSV---ISFSR-----V 503

Human   470 CSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAG 508
            |...|       |||.. ||.|...:|:.:...:|.:.|
  Fly   504 CLLFC-------PFLSC-LTVIHHLVPITILATMGWIYG 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	105/552 (19%)
		MFS	124..492	CDD:119392	74/395 (19%)
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	105/552 (19%)
		MFS	164..540	CDD:119392	73/389 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840