Protein Alignment SLC22A2 and CG4462

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_650849.1
• Gene: CG4462 / 42376
• FlyBaseID: FBgn0038752
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 118/592 - (19%)
• Similarity: 225/592 - (38%)
• Gaps: 108/592 - (18%)

Human     2 PTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWS 66
            |...|.:.:..|:|..:|.:...::.|.....|.....|:|.|  |:   ..|| :|.:  |
  Fly    37 PAGSDVIADVVGDFGIWQLRTILIIFLCKIPAAWFMACIIFTG--PE---LYPG-SEFT--C--- 90

Human    67 PAEELNYTVPGPGPAGEASPRQCRRYEVDWNQST-FDCVDPLASLDTNRSRLPLGPCRDGWVYET 130
               :.:|.......:...|..||  |.:|.:..| .:|                    :.:.|.:
  Fly    91 ---DTSYLTSSSNSSFSISDNQC--YVLDESTGTSSEC--------------------EQFNYVS 130

Human   131 PGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAA----G 191
            ...|::.:|||||    :.|:|.:........|.:..|.:..:....:...:|..:.|.|    |
  Fly   131 SFDSLIMQFNLVC----LRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCG 191

Human   192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVA 256
            |:...:..::....||.:..:.....:..|..:..:.....:|....|.|...:::|:::|.|::
  Fly   192 VVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLS 256

Human   257 YALPHWRWLQFTVSLPN-FFFLLYYWCIPESPRWLISQN------KNAEAMRIIKHIAKKNGKSL 314
            .....|..:...::.|. ...||.|| .|:|||||:...      .|.|  :|::..|..|.:|.
  Fly   257 SFFNSWSLIYVGITFPTIMLILLLYW-TPDSPRWLLRHAADRFSIDNVE--QILREGAAINDRSF 318

Human   315 ---PASLQRLRLEEETGKKLNP--SFLDL-----VRTPQIRKHTMILMYNWFTSSVLYQGLIMHM 369
               |...|:|....|..|...|  .:.:|     .:|..:..|..:..:     .:.:.|:::::
  Fly   319 KIPPDFRQQLEQLSERLKAQPPPAPWTELWKGKRAKTHMVAAHLALAFF-----VINFMGMLLNI 378

Human   370 GLAG-DNIYLDFFYSALVEFPAAFMII-LTIDRIGRRYPWAAS---NMVAG-AACLASVF----- 423
            ...| |.:..:.......|....|:.: .|:..  .::.|..:   |::|| ..|:..:|
  Fly   379 RSFGRDYLVPNTIAMGFSEIIGCFLALHFTLKH--NKWKWQCAGVFNILAGILGCMGWIFTNADS 441

Human   424 IPGDLQ---WLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFL- 484
            :..||:   |:  ||:.:.:..::.|..::.....||.|...:.|.|....:...:..:..||.
  Fly   442 MDADLKVSLWM--IIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFN 504

Human   485 VYRLTNIWLEL-PLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQ 548
            |.|..:..:.| ...||.:||.:...| ||.|......:...:|:       |..||:.
  Fly   505 VLRKIDTAMSLTSYCVFSILGGICTSL-LLTPRLSVSPVVPHLEQ-------RNTKEQS------ 555

Human   549 KLDIPLN 555
                |||
  Fly   556 ----PLN 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	109/549 (20%)
		MFS	124..492	CDD:119392	79/403 (20%)
CG4462	NP_650849.1	2A0119	<126..532	CDD:273328	85/422 (20%)
		MFS	149..>284	CDD:119392	22/135 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840