Protein Alignment SLC22A2 and CG6231

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_001262734.1
• Gene: CG6231 / 42339
• FlyBaseID: FBgn0038720
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 149/556 - (26%)
• Similarity: 251/556 - (45%)
• Gaps: 76/556 - (13%)

Human     6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVF-----LGFTPDHRCRSPGVAELSLRCGW 65
            |.:|...|:|:.:|   |.:|||..  |..|.|.:.:     :.|.|||.|....:..::
  Fly     4 DQILAKCGDFNRYQ---FMILALFG--FINIIVSMHYFTQTVISFVPDHWCYHDKLVNMT----- 58

Human    66 SPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG--PCRDGWV- 127
                   |...|...|...:| .|.|.:                 |.|...:.:.  .| :.|:
  Fly    59 -------YKEIGEIYAQFENP-SCTRLD-----------------DINGHNVTVSSKAC-EKWIY 97

Human   128 -YETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAG 191
             |:....|:.||.|.||.:::...:.||...:|..:|::..|.::|:.||...|:.:.....|..
  Fly    98 NYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGD 162

Human   192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVA--YTVGLLVLAG 254
            .....:.:.....:.|.|.||.:...:.:.||::.|:: |...||:|:...|.  |.:||:....
  Fly   163 FSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYI-RPSMRTLGLNMAVGLFYCLGLVFTPW 226

Human   255 VAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNG-KSLPASL 318
            :|..:.||:......|||....:|||:.:.||.:||:::|....|:..:|.:||.|| :...|..
  Fly   227 LAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADF 291

Human   319 QRLR-----LEEETG--KKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNI 376
            ...|     ..|..|  .|...:.||:.|||::||:|:||.:.....::.|..:..::...|.:.
  Fly   292 DEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISP 356

Human   377 YLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAG----AACLASVFIPGDLQWLKIIISC 437
            ::.|..|||...|::.:::|..|||||:...:.|.:|.|    ||.:|..:...:..  .|:::|
  Fly   357 FIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQHNHN--AILLAC 419

Human   438 L---GRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWL-----E 494
            |   .|.|:.::||.......||.||.:|..||    :...:.|....||...:  :||     .
  Fly   420 LTIAARFGVAISYESGSQYATELIPTCVRGQGV----AAVHVAGFAASFLAPYI--LWLGTFFKA 478

Human   495 LPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAE 530
            .|.::.|||......:.||||||..::||.||||.|
  Fly   479 APSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGE 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	142/542 (26%)
		MFS	124..492	CDD:119392	104/386 (27%)
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	142/542 (26%)
		MFS	125..499	CDD:119392	103/382 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950