Protein Alignment SLC22A2 and CG14855

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 573
• Identity: 147/573 - (25%)
• Similarity: 243/573 - (42%)
• Gaps: 102/573 - (17%)

Human     6 DDVLEHGGEFHFFQKQMFFLLAL---LSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSP 67
            :::|...|....:|   |.||||   |....:..|.....:.|.|||.|....:...|    ::.
  Fly     4 EEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRS----FAE 61

Human    68 AEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWV--YET 130
            .|::......|         .|.|.|.         :|.    |.....|....| :.|:  |:.
  Fly    62 IEKIYSQFEKP---------SCTRLEK---------IDE----DGQNHTLSRERC-NRWIYKYDF 103

Human   131 PGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLL-----------TTV 184
            ...|:.||.|.||..::...:.||...||...|:::.|.:.||.||...|:           :|:
  Fly   104 GYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTI 168

Human   185 LINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRR-----TVGIFYQVA 244
            .    ||.|.:.|       |.|.|.||.:.|...:.||||.|:|....|.     .:|.|
  Fly   169 F----AGSLTSFS-------ISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSF---- 218

Human   245 YTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKK 309
            |.:||:....:|..:.|||......|:|.....|:|:.:.||.:||:::|....|:|.::.:||.
  Fly   219 YCLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKI 283

Human   310 NGKSLPASLQ----RLRLEEETGKKLN----PSFLDLVRTPQIRKHTMILM---------YNWFT 357
            |.:.: |...    |:..|:...|..|    ...||:::||::|.....|:         ||...
  Fly   284 NRRQV-ADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIA 347

Human   358 SSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRR---YPW-AASNMVAGAAC 418
            .:|  :||       |.:.::.|..:||...|:.::..|..||:||:   ..| |.:.:.|.||.
  Fly   348 RNV--EGL-------GISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAG 403

Human   419 LASVFIPGDLQWLKIII--SCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIIT 481
            |  |...|..:.:.:::  :...|.|:::|.......:.||.||.:|..||.:..........::
  Fly   404 L--VISQGSNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLS 466

Human   482 PFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQR 534
            |:::: |...:...|.::.|:|.|....:.||||||:.|.||.::.|.|...|
  Fly   467 PYILH-LGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGR 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	143/555 (26%)
		MFS	124..492	CDD:119392	106/408 (26%)
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	141/553 (25%)
		MFS	127..499	CDD:119392	103/399 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950