Protein Alignment SLC22A2 and CG44098

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_001262264.1
• Gene: CG44098 / 40590
• FlyBaseID: FBgn0264907
• Length: 813
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 122/574 - (21%)
• Similarity: 225/574 - (39%)
• Gaps: 78/574 - (13%)

Human     1 MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR---CRSPGVAELSLR 62
            |.|.||.|.:..|.:..:|.:...|:.|.....:.....|:|....|.|.   |:.|.......:
  Fly   202 MQTKVDAVGQITGPWGKWQLRTVLLIFLCKIPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQ 266

Human    63 CGWSPAEELNYTVPGPGPAGEASPRQ------CRRYEVD--------WNQSTFDCVDPLASLDTN 113
            ..|.....         |..|.|..|      |..|: |        :|....|....:.....:
  Fly   267 TQWIKVSH---------PQKEESDDQEFSIDFCNVYQ-DAQEHAHHYYNYENSDQEPRVWEKPLH 321

Human   114 RSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178
            |:...: ||.: :.:|:...|:||:::|||:...::.:.|.....|...|.:....:...|..:.
  Fly   322 RNSNVI-PCTE-FQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSPRN 384

Human   179 CLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243
            .:|..::.....|.|.....:|...:.||.:..:.....:..|..::.:..|.:||..|...::.
  Fly   385 VMLFGMITQIFCGNLTGHVASYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTLFEQ 449

Human   244 AYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYW-CIPESPRWLISQNKNAEAMRIIKHIA 307
            .:::|:::|.|||.....|..|...:|.|. ..|:|.| .||:||||||::.:..:|.:|:....
  Fly   450 FWSIGVMMLPGVASFWSSWSHLYMAISWPT-VILIYLWQWIPDSPRWLIARGRTQDAKKILLECV 513

Human   308 KKNGK--SLPASL-QRLRLEEETGKKLNP--SFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIM 367
            :.||.  :||..: |:|.|:.:|.....|  .:..:.:..:..:|.:.:...|....|:|.|:::
  Fly   514 EVNGTGYNLPHDIDQQLELQAQTAMDAPPPSGWWSMWKGERAVRHIVCVHLAWSLYIVVYYGMLL 578

Human   368 HM-GLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAA-SNMVAGAACLASVFIPG---- 426
            :: ..:.|::|::.|::...|....|..:..|.:..|::.|.. .|:|||........:|.
  Fly   579 NIRSFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRKWLWTGLFNIVAGCIAYCGWLVPKPSVI 643

Human   427 DLQWLKIIISC---LGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRL 488
            .|.....::.|   :.:|.|:....|:.....||               :.|....||.|.....
  Fly   644 GLDPNVALLMCSAMVSKMAISTTLSILTTCTVEL---------------VSDDKKKITSFSTICW 693

Human   489 TNIWL--------------ELPLMVFGVLGLVAGGLVLLL---PETKGKALPET 525
            ...||              .:|...|..|.:: |||...|   |.|...:.|.:
  Fly   694 ARFWLLGAPFIGSTVVFGQLIPQTAFASLAIL-GGLCTSLISSPRTHPISRPSS 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	117/560 (21%)
		MFS	124..492	CDD:119392	82/382 (21%)
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	113/544 (21%)
		MFS	353..733	CDD:119392	83/396 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840