Protein Alignment SLC22A2 and CG7458

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 563
• Identity: 156/563 - (27%)
• Similarity: 263/563 - (46%)
• Gaps: 54/563 - (9%)

Human     4 TVDDVLEHGGEFHFFQKQMFFLLA---LLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGW 65
            ::|.:|...|:|..:|...:.||.   |.:|.|:   :..||...|..|||..|       :|.
  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFS---ISYVFTASTVVHRCTVP-------QCD- 90

Human    66 SPA---EE--LNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDP-----LASLDTNRSRLPLG 120
            ||:   ||  |.:|:|....|.:    .|.||..:.:.:.....||     |....|..|.
  Fly    91 SPSSVYEEDWLGFTIPKKNSAWD----DCHRYAANISDAISGYTDPSGQYCLKEYFTITSE---- 147

Human   121 PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVL 185
            .|...:.:.....:|.|||.:.|.:.|.|.:..:..|||.|:|....||.|||:||:..|.....
  Fly   148 TCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGS 212

Human   186 INAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLL 250
            ::|..||:.::|..|:..|:|..:...|....:...::|..|.||.:.|........:.|.:|..
  Fly   213 VSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEA 277

Human   251 VLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLP 315
            .|..:|..:.|||||...:..|....:|:.|.:|||.|||:||....:|..:::..|:.|.:.||
  Fly   278 FLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLP 342

Human   316 ASLQRLRLEEETGKKL--NPSFLDLVRTPQIRKHTMILMYN---------WFTSSVLYQGLIMHM 369
                    ||:....|  |...|......|......::.::         |||.:::..||.::.
  Fly   343 --------EEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNS 399

Human   370 GLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACL-ASVFIPGDLQWLKI 433
            ...|.|.|.:|..:..::.|...:.::.:||:|||:...|| |:..|.|: ||..:|.|.....:
  Fly   400 VNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCAS-MLLCAICMGASAAVPADNYAGSL 463

Human   434 IISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLM 498
            .:..:|::.||.:::|:....:|::||.:||..:.:||.:..||.::.| ....|...::..|.:
  Fly   464 ALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAP-QTPLLAKYYIYAPQI 527

Human   499 VFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEK 541
            :|....|::|.|.|..|||..|.||.|||||.::.:.::..|:
  Fly   528 LFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSER 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	148/536 (28%)
		MFS	124..492	CDD:119392	103/379 (27%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	148/536 (28%)
		MFS	161..544	CDD:119392	109/392 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030