Protein Alignment SLC22A2 and SLC22A

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 167/559 - (29%)
• Similarity: 262/559 - (46%)
• Gaps: 37/559 - (6%)

Human     4 TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPA 68
            |:|.:|:|.|:|..||..:|.|:.|.....|...|..||...|..|||   .|.|..|.......
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC---SVEECDLPGSNYYE 87

Human    69 EELNYTVPGPGPAGEASPRQCRRYE----VDWNQSTFDCVDPLASLD---TNRSRLPLGPCRDGW 126
            ...|:::|..|...::    |.||.    ..||.|...|     |.|   .|:...    ..:.:
  Fly    88 PHTNWSIPKNGKDLDS----CNRYTNSELPQWNHSVDIC-----SADHFTKNKEAC----AHNEF 139

Human   127 VYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAG 191
            |:.....:|..:|.:.|.:.|.|.:..:..|:|.|.|....|::|||:||...:....::.|..|
  Fly   140 VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLG 204

Human   192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVA 256
            |:.:.||:|.|.|:|..:..:.|...:...:::..|.||.:.|........|.|.||.::||..|
  Fly   205 VIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSA 269

Human   257 YALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPAS-LQR 320
            .|...||.|......|:...|.|:|.:|||.|||:||.|...|..|::..|..|.:.||.| |.:
  Fly   270 KAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDK 334

Human   321 LRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYN----WFTSSVLYQGLIMHMGLAGDNIYLDFF 381
            |.|...  .||..|........:..|:....:.|    |....::|.||.:::.|...:.|.:|.
  Fly   335 LVLANR--DKLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNNFA 397

Human   382 YSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMA 446
            |.||||.|..||.:|.:||.||||......:.:|..|:.::|...|...|::::..:|::.||.:
  Fly   398 YIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITAS 462

Human   447 YEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII---TPFLVYRLTNIWLELPLMVFGVLGLVAG 508
            ::::....:|:|||.:||..:..||.|...|.::   ||.|.....|    .|.|:|....:|:|
  Fly   463 FQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYAN----APAMLFAGAAIVSG 523

Human   509 GLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQV 547
            .|.|..|||....||.|::||:.:...:::|.|.:.|.|
  Fly   524 LLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVV 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	156/526 (30%)
		MFS	124..492	CDD:119392	113/375 (30%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/526 (30%)
		MFS	146..530	CDD:119392	119/389 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030