DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A2 and CG5592

DIOPT Version :9

Sequence 1:	NP_003049.2	Gene:	SLC22A2 / 6582	HGNCID:	10966	Length:	555	Species:	Homo sapiens
Sequence 2:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	170/556 - (30%)
Similarity:	266/556 - (47%)	Gaps:	58/556 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    13 GEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTP-DHRCRSPGVAELSLRCGWSPAEELNYTVP 76
            |:|..|||::.|.:...:..||..|.|.:|:...| :|.||   |.||.   |...:|:.|..:|
  Fly    17 GDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR---VRELE---GLPESEQKNRGIP 75

Human    77 GPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVY---ETPGSSIVTE 138
               ...:.|...|..|.|.:        |..|:.|.|::|.|: ||.:||:|   |.|..||.||
  Fly    76 ---KKQDGSFENCFMYNVPY--------DSNATNDANQTRSPI-PCNNGWIYDRKEVPYESIATE 128

Human   139 FNLVCANSWMLDLFQSSV---NVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTY 200
            :|.||...   |....||   .||..:|.:..|:|.|..||...|......:...|.:..:...:
  Fly   129 YNWVCDKR---DFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDF 190

Human   201 TWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVG----IFYQVAYTVGLLVLAGVAYALPH 261
            ......|.:.||.....::..|||..|.||.:||..||    .|:   :|:|..:|..:||.:.:
  Fly   191 PCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFF---FTLGACLLPWLAYVISN 252

Human   262 WRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASL-QRLR--- 322
            ||.....|:||..|.:|.....||||.||:|..|....:.::|..||.|||.:...: ..:|
  Fly   253 WRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECY 317

Human   323 ----LEEETGKKLNPSFLDLVRT-PQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFY 382
                ..|:.||:.  :.|||.:| |::...| ||:..|.|.::.|...:..:.:...:|::.|..
  Fly   318 ELKFANEQLGKQY--TSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTDIFITFSL 379

Human   383 SALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQ--WLKIIISCLGRMGITM 445
            |:|||.||..:.:|.:|||||: |..::.|:   .|.||....|.|:  |.....:...|...||
  Fly   380 SSLVEIPAGIVPMLLLDRIGRK-PMMSAVML---LCAASSLFVGILKGHWNASTAAIAARFFATM 440

Human   446 AYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGL 510
            ||.:.....:|:.||.:|..|:.|.:.|..:|.:::| ||......:..||:.:..::.::...:
  Fly   441 AYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFIITLVSVIGALI 504

Human   511 VLLLPETKGKALPETIEEAENMQ----RPRKNKEKM 542
            :|.||||||..:|:|::|||...    |.||..|.:
  Fly   505 ILFLPETKGATMPQTLDEAEKRWTLRCRDRKINEDL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	162/533 (30%)
SLC22A2	NP_003049.2	MFS	124..492	CDD:119392	118/388 (30%)
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	162/533 (30%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	108/378 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850