Protein Alignment SLC22A2 and Glut1

DIOPT Version :9

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_612073.2
• Gene: Glut1 / 38109
• FlyBaseID: FBgn0264574
• Length: 1440
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 110/455 - (24%)
• Similarity: 186/455 - (40%)
• Gaps: 101/455 - (22%)

Human   132 GSSIVTEFNLVCANSWMLDLFQSSVN---VGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVL 193
            |..|..||        :..|:..:|:   :|..:|..|.|::|:|||||..||...::..|...|
  Fly    54 GEDISEEF--------IQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACL 110

Human   194 MA---ISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLV--LA 253
            |.   :|.:|..:.:.|.|.|:.......:..:.|:|......|..:|...|:|.|||||:  :.
  Fly   111 MGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVL 175

Human   254 GVAYAL---PHWRWLQFTVSLPNFFFLLYYWCIPESPRW-LISQNKNAEAMRIIKHIAKKNGKSL 314
            |:...|   ..|..|......|....|:.....|||||: ||::....||.:.::.: :.:| |:
  Fly   176 GIEQILGTNEGWPILLGLAICPAILQLILLPVCPESPRYLLITKQWEEEARKALRRL-RASG-SV 238

Human   315 PASLQRLRLEEETGK-KLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYL 378
            ...::.:|.||...: :.:.|.::|:.:|.:|...:|             |::|.:......|..
  Fly   239 EEDIEEMRAEERAQQSESHISTMELICSPTLRPPLII-------------GIVMQLSQQFSGINA 290

Human   379 DFFY-------SALVEFPAAF--------MIILTI------DRIGRR----YPWAASNMVAGAAC 418
            .|:|       |.|.|..|.|        |:::|:      ||.|||    |.       .|...
  Fly   291 VFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRRTLHLYG-------LGGMF 348

Human   419 LASVFIPGD------LQWLKIIISCLGRMGITMAY-----EIVCLVNAELYPTFIRNLGVHIC-- 470
            :.|:||...      :.|:. .:|.:..:|..:.:     .|..::.|||:....|...:.|.
  Fly   349 IFSIFITISFLIKEMIDWMS-YLSVVATLGFVVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVL 412

Human   471 -SSMCD-IGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLL-------LPETKGKALPETI 526
             :.|.: :.||..|.:...|.| :..||..||         |.:.       :||||.|...|.:
  Fly   413 VNWMANFVVGIGFPSMKTALEN-YTFLPFSVF---------LAIFWIFTYKKVPETKNKTFEEIL 467

Human   527  526
              Fly   468  467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	109/452 (24%)
		MFS	124..492	CDD:119392	99/412 (24%)
Glut1	NP_612073.2	MFS	17..452	CDD:119392	104/438 (24%)
		Sugar_tr	18..470	CDD:278511	110/455 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326501at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920