Protein Alignment SLC22A2 and Balat

DIOPT Version :10

• Sequence 1: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_610823.1
• Gene: Balat / 36417
• FlyBaseID: FBgn0033778
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 174/558 - (31%)
• Similarity: 278/558 - (49%)
• Gaps: 55/558 - (9%)

Human     6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYV-GIVFLGFTPDHRCRSPGVAELSLRCGWS-PA 68
            |:||...|.|..:||.:...:.|.:|.....:. ..:|:..||.|.||.|   ||.   .|: ..
  Fly     4 DEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP---ELE---PWTQDY 62

Human    69 EEL--NYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCV----------------DPLASLDTNRS 115
            .:|  |.::|.......|   :|..|..::.    |.|                :.|..|..:.:
  Fly    63 VQLVKNLSIPRNRNGAYA---ECSMYSRNYT----DIVRYLEYRPPPDLLRQQAEDLLKLQPDTT 120

Human   116 RLPLGPCRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178
            ::.  ||:.||.|:..  .|::|.|:||||..|:::.|......||..:|:...||:.|.:||:.
  Fly   121 QVV--PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRP 183

Human   179 CLLTTVLINAAAGVLMAIS-PTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQ 242
            .....:|:...|....|.: ..||| |..|.:.||...|.....|:|..|.||...|....|...
  Fly   184 SFYAYLLLEIIACAASAFAWNYYTW-LGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSN 247

Human   243 VAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIA 307
            :||::||:|||||.|.:..||.|...||:|.......::.:|||||||::..|...|::|:|.:|
  Fly   248 IAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMA 312

Human   308 KKNG----KSLPASLQR---LRLEEETGKKLNPSF--LDLVRTPQIRKHTMILMYNWFTSSVLYQ 363
            :.||    :.....|||   :....||...:...:  |||.|.|.:|:.|:|:...||.::.:|.
  Fly   313 RVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYV 377

Human   364 GLIMHM-GLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGD 427
            ||..:. .|.||.|: :||.:..||.|...::...:...|||:....|.:|.|.||:|:...|.
  Fly   378 GLSYYAPALGGDEIW-NFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD- 440

Human   428 LQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIW 492
               :.:::.|:|:|||:.::.::.|:.:|||||.:|.||:...|.:..:|.|:.| ::..:....
  Fly   441 ---ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP-MINHMGQQM 501

Human   493 LELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAE 530
            |.|||:|.|.|.::.|...||||||:.:.||:|:||.|
  Fly   502 LVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	167/544 (31%)
		Proline-rich sequence. /evidence=ECO:0000269|PubMed:26979622	284..288		3/3 (100%)
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	133/402 (33%)